The DOI matches its Crossref record; 58 of the 58 references it cites were found in a registry or an index.
Dephosphorylation of d-Peptide Derivatives to Form Biofunctional, Supramolecular Nanofibers/Hydrogels and Their Potential Applications for Intracellular Imaging and Intratumoral Chemotherapy
Open accessAbstract
D-Peptides, as the enantiomers of the naturally occurring L-peptides, usually resist endogenous proteases and are presumably insensitive to most enzymes. But, it is unclear whether or how a phosphatase catalyzes the dephosphorylation from D-peptides. In this work, we examine the formation of the nanofibers of D-peptides via enzymatic dephosphorylation. By comparing the enzymatic hydrogelation of L-peptide and D-peptide based hydrogelators, we find that the chirality of the precursors of the hydrogelators affects little on the enzymatic hydrogelation resulted from the removal of the phosphate group from a tyrosine phosphate residue. The attachment of a therapeutic agent (e.g., taxol) or a fluorophore (e.g., 4-nitro-2,1,3-benzoxadiazole) to the D-peptide based hydrogelators affords a new type of biostable or biocompatible hydrogelators, which may find applications in intratumoral chemotherapy or intracellular imaging, respectively. This work, as the first comprehensive and systematic study of the unexpected enzymatic dephosphorylation of D-peptides, illustrates a useful approach to generate supramolecular hydrogels that have both biostability and other desired functions.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Whitesides, G. M., & Grzybowski, B. (2002) · Science · doi:10.1126/science.1070821 · Cited by 7,439
Lehn, J. (1988) · Angewandte Chemie International Edition in English · doi:10.1002/anie.198800891 · Cited by 3,856
Self-Assembly and Mineralization of Peptide-Amphiphile Nanofibers
Hartgerink, J. D., Beniash, E., & Stupp, S. I. (2001) · Science · doi:10.1126/science.1063187 · Cited by 3,601
Low Molecular Mass Gelators of Organic Liquids and the Properties of Their Gels
Terech, P., & Weiss, R. G. (1997) · Chemical Reviews · doi:10.1021/cr9700282 · Cited by 3,130
Water Gelation by Small Organic Molecules
Estroff, L. A., & Hamilton, A. D. (2004) · Chemical Reviews · doi:10.1021/cr0302049 · Cited by 2,034
Self‐assembly of peptide amphiphiles: From molecules to nanostructures to biomaterials
Cui, H., Webber, M. J., & Stupp, S. I. (2010) · Peptide Science · doi:10.1002/bip.21328 · Cited by 1,549
(2000) · Cited by 1,342
Extensive neurite outgrowth and active synapse formation on self-assembling peptide scaffolds
Holmes, T. C., de Lacalle, S., Su, X., Liu, G., Rich, A., & Zhang, S. (2000) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.97.12.6728 · Cited by 1,124
Structure and Mechanism of Alkaline Phosphatase
Coleman, J. E. (1992) · Annual Review of Biophysics and Biomolecular Structure · doi:10.1146/annurev.bb.21.060192.002301 · Cited by 883
d -Amino Acids Trigger Biofilm Disassembly
Kolodkin-Gal, I., Romero, D., Cao, S., Clardy, J., Kolter, R., & Losick, R. (2010) · Science · doi:10.1126/science.1188628 · Cited by 874
Cited by
Supramolecular Chirality in Self-Assembled Systems
Liu, M., Zhang, L., & Wang, T. (2015) · Chemical Reviews · doi:10.1021/cr500671p · Cited by 2,250
Functional π-Gelators and Their Applications
Babu, S. S., Praveen, V. K., & Ajayaghosh, A. (2014) · Chemical Reviews · doi:10.1021/cr400195e · Cited by 1,725
Three-dimensional in vitro cell culture models in drug discovery and drug repositioning
Langhans, S. A. (2018) · Frontiers in Pharmacology · doi:10.3389/fphar.2018.00006 · Cited by 1,522
Lu, P., Ruan, D., Huang, M., Tian, M., Zhu, K., Gan, Z., & Xiao, Z. (2024) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-024-01852-x · Cited by 667
Supramolecular hydrogels: synthesis, properties and their biomedical applications
Dong, R., Pang, Y., Su, Y., & Zhu, X. (2015) · Biomaterials Science · doi:10.1039/c4bm00448e · Cited by 302
Metadata
- Authors
- Li, J., Gao, Y., Kuang, Y., Shi, J., Du, X., Zhou, J., Wang, H., Yang, Z., & Xu, B.
- Venue
- Journal of the American Chemical Society
- Publisher
- American Chemical Society (ACS)
- Published
- 2013-06-21
- Volume
- 135
- Issue
- 26
- Pages
- 9907-9914
- ISSN
- 0002-7863 (ISSN-L)
- 1520-5126
- OpenAlex
- W2074363870
- Cited by
- 254
- References
- 58
- FWCI
- 11.02
- Type
- journal article
- Language
- en
- Open access
- green
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
How to cite
Cite CoChat for the checks on this page, and the paper for its own findings.
- This page
- CoChat. (2026). Citation check: Dephosphorylation of d-Peptide Derivatives to Form Biofunctional, Supramolecular Nanofibers/Hydrogels and Their Potential Applications for Intracellular Imaging and Intratumoral Chemotherapy. https://app.cochat.ai/papers/10.1021/ja404215g
- The paper
- Li, J., Gao, Y., Kuang, Y., Shi, J., Du, X., Zhou, J., Wang, H., Yang, Z., & Xu, B. (2013). Dephosphorylation of d-Peptide Derivatives to Form Biofunctional, Supramolecular Nanofibers/Hydrogels and Their Potential Applications for Intracellular Imaging and Intratumoral Chemotherapy. Journal of the American Chemical Society. https://doi.org/10.1021/ja404215g
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
