The DOI matches its Crossref record; 25 of the 25 references it cites were found in a registry or an index.
An Off–On COX-2-Specific Fluorescent Probe: Targeting the Golgi Apparatus of Cancer Cells
Abstract
Identifying cancer cells and quantifying cancer-related events in particular organelles in a rapid and sensitive fashion are important for early diagnosis and for studies on pathology and therapeutics of cancers. Herein a smart "off-on" cyclooxygenase-2-specific fluorescence probe (ANQ-IMC-6), able to report the presence of cancer cells and to image Golgi-related events, has been designed and evaluated. Cyclooxygenase-2 (COX-2) has been used as imaging target in the probe design, since this enzyme is a biomarker of virtually all cancer cell lines. In the free state in aqueous solution, ANQ-IMC-6 mainly exists in a folded conformation where probe fluorescence is quenched through photoinduced electron transfer between the fluorophore acenaphtho[1,2-b]quinoxaline (ANQ) and the recognition group, indomethacin (IMC). Fluorescence is turned on, by restraining the photoinduced electron transfer, when ANQ-IMC-6 is forced to adopt the unfolded state following binding to COX-2 in the Golgi apparatus of cancer cells. ANQ-IMC-6 provides high signal-to-background staining and has been successfully used to rapidly differentiate cancer cells from normal cells when using flow cytometry and one- and two-photon fluorescence microscopic imaging. Furthermore, ANQ-IMC-6 may be able to visualize dynamic changes of the Golgi apparatus during cancer cell apoptosis, with possible application to early diagnosis.
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Metadata
- Authors
- Zhang, H., Fan, J., Wang, J., Zhang, S., Dou, B., & Peng, X.
- Venue
- Journal of the American Chemical Society
- Publisher
- American Chemical Society (ACS)
- Published
- 2013-07-29
- Volume
- 135
- Issue
- 31
- Pages
- 11663-11669
- ISSN
- 0002-7863 (ISSN-L)
- 1520-5126
- OpenAlex
- W2144119801
- Cited by
- 324
- References
- 25
- FWCI
- 10.14
- Type
- journal article
- Language
- en
- Open access
- closed
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