The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.
Genetically Encoded Fluorescent Probe for the Selective Detection of Peroxynitrite
Abstract
Peroxynitrite is a highly reactive molecule involved in cell signaling and pathological processes. We hereby report a novel genetically encoded probe, pnGFP, which can selectively sense peroxynitrite. A boronic acid moiety was site-specifically introduced into circularly permuted fluorescent proteins. By examining different protein templates followed with site-targeted random mutagenesis, we identified a selective peroxynitrite sensor, which is essentially unresponsive to other common cellular redox signaling molecules. The new probe has been genetically introduced into mammalian cells to image peroxynitrite at physiologically relevant concentrations.
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Citations
Cites
Peroxynitrite: biochemistry, pathophysiology and development of therapeutics
Szabó, C., Ischiropoulos, H., & Radi, R. (2007) · Nature Reviews Drug Discovery · doi:10.1038/nrd2222 · Cited by 2,134
Chemical biology of peroxynitrite: Kinetics, diffusion, and radicals
Ferrer-Sueta, G., & Radi, R. (2009) · ACS Chemical Biology · doi:10.1021/cb800279q · Cited by 776
Cited by
Biochemistry of Peroxynitrite and Protein Tyrosine Nitration
Ferrer-Sueta, G., Campolo, N., Trujillo, M., Bartesaghi, S., Carballal, S., Romero, N., Alvarez, B., & Radi, R. (2018) · Chemical Reviews · doi:10.1021/acs.chemrev.7b00568 · Cited by 640
Boronic acids as building blocks for the construction of therapeutically useful bioconjugates
António, J. P. M., Russo, R., Carvalho, C. P., Cal, P. M. S. D., & Gois, P. M. P. (2019) · Chemical Society Reviews · doi:10.1039/c9cs00184k · Cited by 303
Molecular Imaging of Peroxynitrite with HKGreen-4 in Live Cells and Tissues
Peng, T., Wong, N.-K., Chen, X., Chan, Y.-K., Ho, D. H.-H., Sun, Z., Hu, J. J., Shen, J., El-Nezami, H., & Yang, D. (2014) · Journal of the American Chemical Society · doi:10.1021/ja504624q · Cited by 273
Chen, Y., Jin, S., Zhang, M., Hu, Y., Wu, K.-L., Chung, A., Wang, S., Tian, Z., Wang, Y., Wolynes, P. G., et al. (2022) · Nature Communications · doi:10.1038/s41467-022-33111-4 · Cited by 90
Metadata
- Authors
- Chen, Z.-J., Ren, W., Wright, Q. E., & Ai, H.-W.
- Venue
- Journal of the American Chemical Society
- Publisher
- American Chemical Society (ACS)
- Published
- 2013-09-26
- Volume
- 135
- Issue
- 40
- Pages
- 14940-14943
- ISSN
- 0002-7863 (ISSN-L)
- 1520-5126
- OpenAlex
- W2008071707
- Cited by
- 166
- References
- 2
- FWCI
- 9.30
- Type
- journal article
- Language
- en
- Open access
- closed
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- Chen, Z.-J., Ren, W., Wright, Q. E., & Ai, H.-W. (2013). Genetically Encoded Fluorescent Probe for the Selective Detection of Peroxynitrite. Journal of the American Chemical Society. https://doi.org/10.1021/ja408011q
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