The DOI matches its Crossref record; 72 of the 72 references it cites were found in a registry or an index.
Molecular Imaging of Peroxynitrite with HKGreen-4 in Live Cells and Tissues
Abstract
Peroxynitrite (ONOO(-)), the product of a radical combination reaction of nitric oxide and superoxide, is a potent biological oxidant involved in a broad spectrum of physiological and pathological processes. Herein we report the development, characterization, and biological applications of a new fluorescent probe, HKGreen-4, for peroxynitrite detection and imaging. HKGreen-4 utilizes a peroxynitrite-triggered oxidative N-dearylation reaction to achieve an exceptionally sensitive and selective fluorescence turn-on response toward peroxynitrite in chemical systems and biological samples. We have thoroughly evaluated the utility of HKGreen-4 for intracellular peroxynitrite imaging and, more importantly, demonstrated that HKGreen-4 can be efficiently employed to visualize endogenous peroxynitrite generated in Escherichia coli-challenged macrophages and in live tissues from a mouse model of atherosclerosis. This probe should serve as a powerful molecular imaging tool to explore peroxynitrite biology under a variety of physiological and pathological contexts.
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Cites
Nitric Oxide and Peroxynitrite in Health and Disease
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Nitric oxide and the immune response
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Peroxynitrite: biochemistry, pathophysiology and development of therapeutics
Szabó, C., Ischiropoulos, H., & Radi, R. (2007) · Nature Reviews Drug Discovery · doi:10.1038/nrd2222 · Cited by 2,134
Reaction-based small-molecule fluorescent probes for chemoselective bioimaging
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Design Strategies for Water-Soluble Small Molecular Chromogenic and Fluorogenic Probes
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Detection and Imaging of Nitric Oxide with Novel Fluorescent Indicators: Diaminofluoresceins
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Cited by
Redox Signaling by Reactive Electrophiles and Oxidants
Parvez, S., Long, M. J. C., Poganik, J. R., & Aye, Y. (2018) · Chemical Reviews · doi:10.1021/acs.chemrev.7b00698 · Cited by 359
Cheng, D., Peng, J., Lv, Y., Su, D., Liu, D., Chen, M., Yuan, L., & Zhang, X. (2019) · Journal of the American Chemical Society · doi:10.1021/jacs.9b01374 · Cited by 308
Hu, J. J., Wong, N.-K., Ye, S., Chen, X., Lu, M.-Y., Zhao, A. Q., Guo, Y., Ma, A. C.-H., Leung, A. Y.-H., Shen, J., et al. (2015) · Journal of the American Chemical Society · doi:10.1021/jacs.5b01881 · Cited by 279
Self-citationROS/RNS as molecular signatures of chronic liver diseases
Che, Z., Zhou, Z., Li, S.-Q., Gao, L., Xiao, J., & Wong, N.-K. (2023) · Trends in Molecular Medicine · doi:10.1016/j.molmed.2023.08.001 · Cited by 110
Self-citation
Metadata
- Authors
- Peng, T., Wong, N.-K., Chen, X., Chan, Y.-K., Ho, D. H.-H., Sun, Z., Hu, J. J., Shen, J., El-Nezami, H., & Yang, D.
- Venue
- Journal of the American Chemical Society
- Publisher
- American Chemical Society (ACS)
- Published
- 2014-08-07
- Volume
- 136
- Issue
- 33
- Pages
- 11728-11734
- ISSN
- 0002-7863 (ISSN-L)
- 1520-5126
- OpenAlex
- W2053951897
- Cited by
- 273
- References
- 72
- FWCI
- 9.80
- Type
- journal article
- Language
- en
- Open access
- closed
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- Peng, T., Wong, N.-K., Chen, X., Chan, Y.-K., Ho, D. H.-H., Sun, Z., Hu, J. J., Shen, J., El-Nezami, H., & Yang, D. (2014). Molecular Imaging of Peroxynitrite with HKGreen-4 in Live Cells and Tissues. Journal of the American Chemical Society. https://doi.org/10.1021/ja504624q
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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