The DOI matches its Crossref record; 3 of the 3 references it cites were found in a registry or an index.
A Red-Shifted, Fast-Relaxing Azobenzene Photoswitch for Visible Light Control of an Ionotropic Glutamate Receptor
Open accessAbstract
The use of azobenzene photoswitches has become a dependable method for rapid and exact modulation of biological processes and material science systems. The requirement of ultraviolet light for azobenzene isomerization is not ideal for biological systems due to poor tissue penetration and potentially damaging effects. While modified azobenzene cores with a red-shifted cis-to-trans isomerization have been previously described, they have not yet been incorporated into a powerful method to control protein function: the photoswitchable tethered ligand (PTL) approach. We report the synthesis and characterization of a red-shifted PTL, L-MAG0460, for the light-gated ionotropic glutamate receptor LiGluR. In cultured mammalian cells, the LiGluR+L-MAG0460 system is activated rapidly by illumination with 400-520 nm light to generate a large ionic current. The current rapidly turns off in the dark as the PTL relaxes thermally back to the trans configuration. The visible light excitation and single-wavelength behavior considerably simplify use and should improve utilization in tissue.
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Cites
Synaptic mechanisms for plasticity in neocortex
Feldman, D. E. (2009) · Annual Review of Neuroscience · doi:10.1146/annurev.neuro.051508.135516 · Cited by 704
Optogenetic dissection of a behavioural module in the vertebrate spinal cord
Wyart, C., Bene, F. D., Warp, E., Scott, E. K., Trauner, D., Baier, H., & Isacoff, E. Y. (2009) · Nature · doi:10.1038/nature08323 · Cited by 409
Self-citationLiGluR restores visual responses in rodent models of inherited blindness
Caporale, N., Kolstad, K. D., Lee, T., Tochitsky, I., Dalkara, D., Trauner, D., Kramer, R., Dan, Y., Isacoff, E. Y., & Flannery, J. G. (2011) · Molecular Therapy · doi:10.1038/mt.2011.103 · Cited by 182
Cited by
Silencing Neurons: Tools, Applications, and Experimental Constraints
Wiegert, J. S., Mahn, M., Prigge, M., Printz, Y., & Yizhar, O. (2017) · Neuron · doi:10.1016/j.neuron.2017.06.050 · Cited by 312
Acylhydrazones as Widely Tunable Photoswitches
van Dijken, D. J., Kovaříček, P., Ihrig, S. P., & Hecht, S. (2015) · Journal of the American Chemical Society · doi:10.1021/jacs.5b09519 · Cited by 293
Helmy, S., Oh, S., Leibfarth, F. A., Hawker, C. J., & Read de Alaniz, J. (2014) · The Journal of Organic Chemistry · doi:10.1021/jo502206g · Cited by 283
Retinal stimulation strategies to restore vision: fundamentals and systems
Yue, L., Weiland, J. D., Roska, B., & Humayun, M. S. (2016) · Progress in Retinal and Eye Research · doi:10.1016/j.preteyeres.2016.05.002 · Cited by 272
Metadata
- Authors
- Kienzler, M. A., Reiner, A., Trautman, E., Yoo, S., Trauner, D., & Isacoff, E. Y.
- Venue
- Journal of the American Chemical Society
- Publisher
- American Chemical Society (ACS)
- Published
- 2013-11-14
- Volume
- 135
- Issue
- 47
- Pages
- 17683-17686
- ISSN
- 0002-7863 (ISSN-L)
- 1520-5126
- OpenAlex
- W2024880201
- Cited by
- 224
- References
- 3
- FWCI
- 9.92
- Type
- journal article
- Language
- en
- Open access
- green
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- Kienzler, M. A., Reiner, A., Trautman, E., Yoo, S., Trauner, D., & Isacoff, E. Y. (2013). A Red-Shifted, Fast-Relaxing Azobenzene Photoswitch for Visible Light Control of an Ionotropic Glutamate Receptor. Journal of the American Chemical Society. https://doi.org/10.1021/ja408104w
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