Synaptic mechanisms for plasticity in neocortex
Open accessAbstract
Sensory experience and learning alter sensory representations in cerebral cortex. The synaptic mechanisms underlying sensory cortical plasticity have long been sought. Recent work indicates that long-term cortical plasticity is a complex, multicomponent process involving multiple synaptic and cellular mechanisms. Sensory use, disuse, and training drive long-term potentiation and depression (LTP and LTD), homeostatic synaptic plasticity and plasticity of intrinsic excitability, and structural changes including formation, removal, and morphological remodeling of cortical synapses and dendritic spines. Both excitatory and inhibitory circuits are strongly regulated by experience. This review summarizes these findings and proposes that these mechanisms map onto specific functional components of plasticity, which occur in common across the primary somatosensory, visual, and auditory cortices.
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Synaptic plasticity at cortical-cortical synapses follows classical two-factor Hebbian learning rules.
“Instead, although dopamine may facilitate cortical LTP, there is much evidence that synaptic plasticity at cortical-cortical synapses follows classical two-factor Hebbian learning rules (for a review, see [76]).”
From Cortical and basal ganglia contributions to habit learning and automaticity (2010) · cites this paper as [76]
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- Authors
- Feldman, D. E.
- Affiliations
- University of California, Berkeley (US)
- Corresponding author
- Feldman, Daniel E.
- ORCID
- Feldman, Daniel E.
- Venue
- Annual Review of Neuroscience
- Publisher
- Annual Reviews
- Published
- 2009-06-01
- Volume
- 32
- Issue
- 1
- Pages
- 33-55
- ISSN
- 0147-006X (ISSN-L)
- 1545-4126
- PMC
- PMC3071739
- OpenAlex
- W2158046593
- Cited by
- 704
- References
- 170
- Citations by year
- 2026: 17 · 2025: 28 · 2024: 34 · 2023: 38 · 2022: 22 · 2021: 43 · 2020: 33 · 2019: 33 · 2018: 35 · 2017: 50 · 2016: 35 · 2015: 38 · 2014: 51 · 2013: 69 · 2012: 54
- FWCI
- 5.15
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Annual Review of Neuroscience (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institute of Neurological Disorders and Stroke (R01NS046652)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neural dynamics and brain function
- Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
- Keywords
- synaptic plasticity, neocortex, long-term potentiation, long-term depression, homeostatic plasticity, intrinsic excitability, dendritic spines, sensory experience, primary somatosensory cortex, visual cortex, auditory cortex, inhibitory circuits
- MeSH terms
- Animals, Cerebral Cortex, Humans, Neural Inhibition, Neural Pathways, Synaptic Transmission, Neuronal Plasticity, Perception, Sensation, Synapses, Long-Term Potentiation
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