The DOI matches its Crossref record; 229 of the 229 references it cites were found in a registry or an index.
Silencing Neurons: Tools, Applications, and Experimental Constraints
Open accessAbstract
Reversible silencing of neuronal activity is a powerful approach for isolating the roles of specific neuronal populations in circuit dynamics and behavior. In contrast with neuronal excitation, for which the majority of studies have used a limited number of optogenetic and chemogenetic tools, the number of genetically encoded tools used for inhibition of neuronal activity has vastly expanded. Silencing strategies vary widely in their mechanism of action and in their spatial and temporal scales. Although such manipulations are commonly applied, the design and interpretation of neuronal silencing experiments present unique challenges, both technically and conceptually. Here, we review the most commonly used tools for silencing neuronal activity and provide an in-depth analysis of their mechanism of action and utility for particular experimental applications. We further discuss the considerations that need to be given to experimental design, analysis, and interpretation of collected data. Finally, we discuss future directions for the development of new silencing approaches in neuroscience.
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Top-down control of sweet and bitter taste in the mammalian brain
Jin, H., Fishman, Z. H., Ye, M., Wang, L., & Zuker, C. S. (2021) · Cell · doi:10.1016/j.cell.2020.12.014 · Cited by 91
Adult-born neurons boost odor-reward association
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Neural mechanisms of economic choices in mice
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Metadata
- Authors
- Wiegert, J. S., Mahn, M., Prigge, M., Printz, Y., & Yizhar, O.
- Venue
- Neuron
- Publisher
- Elsevier BV
- Published
- 2017-08
- Volume
- 95
- Issue
- 3
- Pages
- 504-529
- ISSN
- 0896-6273 (ISSN-L)
- OpenAlex
- W2744000261
- Cited by
- 312
- References
- 229
- FWCI
- 12.68
- Type
- journal article
- Language
- en
- Open access
- bronze
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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