The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.
Benzimidazole-Based Ratiometric Two-Photon Fluorescent Probes for Acidic pH in Live Cells and Tissues
Abstract
Many aspects of cell metabolism are controlled by acidic pH. We report a new family of small molecule and ratiometric two photon (TP) probes derived from benzimidazole (BH1-3 and BH1L) for monitoring acidic pH values. These probes are characterized by a strong two-photon excited fluorescence, a marked blue-to-green emission color change in response to pH, pKa values ranging from 4.9 to 6.1, a distinctive isoemissive point, negligible cytotoxicity, and high photostability, thereby allowing quantitative analysis of acidic pH. Moreover, we show that BH1L optimized as a lysosomal-targeted probe allows for direct, real-time estimation of the pH values inside lysosomal compartments in live cells as well as in living mouse brain tissues through the use of two-photon microscopy. These findings demonstrate that these probes will find useful applications in biomedical research.
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Kuhn, H., Dickinson-Anson, H., & Gage, F. (1996) · The Journal of Neuroscience · doi:10.1523/jneurosci.16-06-02027.1996 · Cited by 3,139
Functional neurogenesis in the adult hippocampus
van Praag, H., Schinder, A. F., Christie, B. R., Toni, N., Palmer, T. D., & Gage, F. H. (2002) · Nature · doi:10.1038/4151030a · Cited by 2,853
Cited by
Small molecule-based ratiometric fluorescence probes for cations, anions, and biomolecules
Lee, M. H., Kim, J. S., & Sessler, J. L. (2015) · Chemical Society Reviews · doi:10.1039/c4cs00280f · Cited by 1,642
Small-Molecule Two-Photon Probes for Bioimaging Applications
Kim, H. M., & Cho, B. R. (2015) · Chemical Reviews · doi:10.1021/cr5004425 · Cited by 1,047
Self-citationWan, Q., Chen, S., Shi, W., Li, L., & Ma, H. (2014) · Angewandte Chemie International Edition · doi:10.1002/anie.201405742 · Cited by 420
He, L., Li, Y., Tan, C.-P., Ye, R.-R., Chen, M.-H., Cao, J.-J., Ji, L.-N., & Mao, Z.-W. (2015) · Chemical Science · doi:10.1039/c5sc01955a · Cited by 358
Ratiometric photoluminescence sensing based on Ti3C2MXene quantum dots as an intracellular pH sensor
Chen, X., Sun, X., Xu, W., Pan, G., Zhou, D., Zhu, J., Wang, H., Bai, X., Dong, B., & Song, H. (2018) · Nanoscale · doi:10.1039/c7nr06958h · Cited by 316
Metadata
- Authors
- Kim, H. J., Heo, C. H., & Kim, H. M.
- Venue
- Journal of the American Chemical Society
- Publisher
- American Chemical Society (ACS)
- Published
- 2013-11-18
- Volume
- 135
- Issue
- 47
- Pages
- 17969-17977
- ISSN
- 0002-7863 (ISSN-L)
- 1520-5126
- OpenAlex
- W2320213632
- Cited by
- 333
- References
- 2
- FWCI
- 16.70
- Type
- journal article
- Language
- en
- Open access
- closed
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