The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.
In Vivo Multimodality Imaging and Cancer Therapy by Near-Infrared Light-Triggered trans-Platinum Pro-Drug-Conjugated Upconverison Nanoparticles
Abstract
Controlling anticancer drug activity and release on demand is very significant in cancer therapy. The photoactivated platinum(IV) pro-drug is stable in the dark and can be activated by UV light. In this study, we develop a multifunctional drug delivery system combining upconversion luminescence/magnetic resonance/computer tomography trimodality imaging and NIR-activated platinum pro-drug delivery. We use the core-shell structured upconversion nanoparticles to convert the absorbed NIR light into UV to activate the trans-platinum(IV) pro-drug, trans,trans,trans-[Pt(N3)2(NH3)(py)(O2CCH2CH2COOH)2]. Compared with using the UV directly, the NIR has a higher tissue penetration depth and is less harmful to health. Meanwhile, the upconversion nanoparticles can effectively deliver the platinum(IV) pro-drugs into the cells by endocytosis. The mice treated with pro-drug-conjugated nanoparticles under near-infrared (NIR) irradiation demonstrated better inhibition of tumor growth than that under direct UV irradiation. This multifunctional nanocomposite could be used as multimodality bioimaging contrast agents and transducers by converting NIR light into UV for control of drug activity in practical cancer therapy.
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Cites
Nanocarriers as an emerging platform for cancer therapy
Peer, D., Karp, J. M., Hong, S., Farokhzad, O. C., Margalit, R., & Langer, R. (2007) · Nature Nanotechnology · doi:10.1038/nnano.2007.387 · Cited by 8,710
D'Orazio, J., Jarrett, S., Amaro-Ortiz, A., & Scott, T. (2013) · International Journal of Molecular Sciences · doi:10.3390/ijms140612222 · Cited by 1,984
Cited by
Upconversion Nanoparticles: Design, Nanochemistry, and Applications in Theranostics
Chen, G., Qiu, H., Prasad, P. N., & Chen, X. (2014) · Chemical Reviews · doi:10.1021/cr400425h · Cited by 2,699
Recent Strategies to Develop Innovative Photosensitizers for Enhanced Photodynamic Therapy
Pham, T. C., Nguyen, V.-N., Choi, Y., Lee, S., & Yoon, J. (2021) · Chemical Reviews · doi:10.1021/acs.chemrev.1c00381 · Cited by 1,813
Zheng, W., Huang, P., Tu, D., Ma, E., Zhu, H., & Chen, X. (2015) · Chemical Society Reviews · doi:10.1039/c4cs00178h · Cited by 894
Near‐Infrared‐Sensitive Materials Based on Upconverting Nanoparticles
Wu, S., & Butt, H. (2016) · Advanced Materials · doi:10.1002/adma.201502843 · Cited by 417
Dai, Y., Yang, Z., Cheng, S., Wang, Z., Zhang, R., Zhu, G., Wang, Z., Yung, B. C., Tian, R., Jacobson, O., et al. (2018) · Advanced Materials · doi:10.1002/adma.201704877 · Cited by 409
Self-citationWang, L., Dong, H., Li, Y., Xue, C., Sun, L.-D., Yan, C.-H., & Li, Q. (2014) · Journal of the American Chemical Society · doi:10.1021/ja500933h · Cited by 284
Redox-responsive branched-bottlebrush polymers for in vivo MRI and fluorescence imaging
Sowers, M. A., McCombs, J. R., Wang, Y., Paletta, J. T., Morton, S. W., Dreaden, E. C., Boska, M. D., Ottaviani, M. F., Hammond, P. T., Rajca, A., et al. (2014) · Nature Communications · doi:10.1038/ncomms6460 · Cited by 279
Thambi, T., Son, S., Lee, D. S., & Park, J. H. (2016) · Acta Biomaterialia · doi:10.1016/j.actbio.2015.10.011 · Cited by 95
Metadata
- Authors
- Dai, Y., Xiao, H., Liu, J., Yuan, Q., Ma, P., Yang, D., Li, C., Cheng, Z., Hou, Z., Yang, P., & Lin, J.
- Venue
- Journal of the American Chemical Society
- Publisher
- American Chemical Society (ACS)
- Published
- 2013-12-06
- Volume
- 135
- Issue
- 50
- Pages
- 18920-18929
- ISSN
- 0002-7863 (ISSN-L)
- 1520-5126
- OpenAlex
- W2335559092
- Cited by
- 529
- References
- 2
- FWCI
- 35.43
- Type
- journal article
- Language
- en
- Open access
- closed
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