The DOI matches its Crossref record; 3 of the 3 references it cites were found in a registry or an index.
Automated Modular Synthesis of Aptamer–Drug Conjugates for Targeted Drug Delivery
Open accessAbstract
Aptamer-drug conjugates (ApDCs) are promising targeted drug delivery systems for reducing toxicity while increasing the efficacy of chemotherapy. However, current ApDC technologies suffer from problems caused by the complicated preparation and low controllability of drug-aptamer conjugation. To solve such problems, we have designed and synthesized a therapeutic module for solid phase synthesis, which is a phosphoramdite containing an anticancer drug moiety and a photocleavable linker. Using this module, we have realized automated and modular synthesis of ApDCs, and multiple drugs were efficiently incorporated into ApDCs at predesigned positions. The ApDCs not only recognize target cancer cells specifically, but also release drugs in a photocontrollable manner. We demonstrated the potential of automated and modular ApDC technology for applications in targeted cancer therapy.
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Cites
5-Fluorouracil: mechanisms of action and clinical strategies
Longley, D. B., Harkin, D. P., & Johnston, P. G. (2003) · Nature Reviews Cancer · doi:10.1038/nrc1074 · Cited by 5,332
Fluorinated pyrimidines, a new class of tumour-inhibitory compounds
HEIDELBERGER, C., CHAUDHURI, N. K., DANNEBERG, P., MOOREN, D., GRIESBACH, L., DUSCHINSKY, R., SCHNITZER, R. J., PLEVEN, E., & SCHEINER, J. (1957) · Nature · doi:10.1038/179663a0 · Cited by 1,603
Zhang, L., Peritz, A., & Meggers, E. (2005) · Journal of the American Chemical Society · doi:10.1021/ja042564z · Cited by 308
Cited by
Aptamer-integrated DNA nanostructures for biosensing, bioimaging and cancer therapy
Meng, H.-M., Liu, H., Kuai, H., Peng, R., Mo, L., & Zhang, X.-B. (2016) · Chemical Society Reviews · doi:10.1039/c5cs00645g · Cited by 608
Aptamer-based targeted therapy
Zhu, G., & Chen, X. (2018) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2018.08.005 · Cited by 522
Self-citationNucleic Acid Aptamers for Molecular Diagnostics and Therapeutics: Advances and Perspectives
Li, L., Xu, S., Yan, H., Li, X., Yazd, H. S., Li, X., Huang, T., Cui, C., Jiang, J., & Tan, W. (2021) · Angewandte Chemie International Edition · doi:10.1002/anie.202003563 · Cited by 432
Self-citationAptamer Nanomedicine for Cancer Therapeutics: Barriers and Potential for Translation
Lao, Y.-H., Phua, K. K. L., & Leong, K. W. (2015) · ACS Nano · doi:10.1021/nn507494p · Cited by 259
Nanocarriers for targeted drug delivery
Shah, A., Aftab, S., Nisar, J., Ashiq, M. N., & Iftikhar, F. J. (2021) · Journal of Drug Delivery Science and Technology · doi:10.1016/j.jddst.2021.102426 · Cited by 161
Metadata
- Authors
- Wang, R., Zhu, G., Mei, L., Xie, Y., Ma, H., Ye, M., Qing, F.-L., & Tan, W.
- Venue
- Journal of the American Chemical Society
- Publisher
- American Chemical Society (ACS)
- Published
- 2014-02-07
- Volume
- 136
- Issue
- 7
- Pages
- 2731-2734
- ISSN
- 0002-7863 (ISSN-L)
- 1520-5126
- OpenAlex
- W1995513865
- Cited by
- 181
- References
- 3
- FWCI
- 7.06
- Type
- journal article
- Language
- en
- Open access
- hybrid
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- Wang, R., Zhu, G., Mei, L., Xie, Y., Ma, H., Ye, M., Qing, F.-L., & Tan, W. (2014). Automated Modular Synthesis of Aptamer–Drug Conjugates for Targeted Drug Delivery. Journal of the American Chemical Society. https://doi.org/10.1021/ja4117395
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