The DOI matches its Crossref record; 4 of the 4 references it cites were found in a registry or an index.
Photopharmacology: Beyond Proof of Principle
Open accessAbstract
Pharmacotherapy is often severely hindered by issues related to poor drug selectivity, including side effects, environmental toxicity, and the emergence of resistance. Lack of selectivity is caused by the inability to control drug activity in time and space. Photopharmacology aims at solving this issue by incorporating photoswitchable groups into the molecular structure of bioactive compounds. These switching units allow for the use of light as an external control element for pharmacological activity, which can be delivered with very high spatiotemporal precision. This Perspective presents the reader with the current state and outlook on photopharmacology. In particular, the principles behind photoregulation of bioactivity, the challenges of molecular design, and the possible therapeutic scenarios are discussed.
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Citations
Cites
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Cited by
Visible‐Light‐Activated Molecular Switches
Bléger, D., & Hecht, S. (2015) · Angewandte Chemie International Edition · doi:10.1002/anie.201500628 · Cited by 853
Heteroaryl azo dyes as molecular photoswitches
Crespi, S., Simeth, N. A., & König, B. (2019) · Nature Reviews Chemistry · doi:10.1038/s41570-019-0074-6 · Cited by 650
ortho‐Fluoroazobenzenes: Visible Light Switches with Very Long‐Lived Z Isomers
Knie, C., Utecht, M., Zhao, F., Kulla, H., Kovalenko, S., Brouwer, A. M., Saalfrank, P., Hecht, S., & Bléger, D. (2014) · Chemistry – A European Journal · doi:10.1002/chem.201404649 · Cited by 438
Current strategies for the design of PROTAC linkers: a critical review
Troup, R. I., Fallan, C., & Baud, M. G. J. (2020) · Exploration of Targeted Anti-tumor Therapy · doi:10.37349/etat.2020.00018 · Cited by 424
“00018 Page 289 have investigated this approach recently using light stimuli to elicit this control, due to the high precision with which this can be applied [95].”
BackgroundRecent developments in reversible photoregulation of oligonucleotide structure and function
Lubbe, A. S., Szymanski, W., & Feringa, B. L. (2017) · Chemical Society Reviews · doi:10.1039/c6cs00461j · Cited by 336
Self-citationRecent Implementations of Molecular Photoswitches into Smart Materials and Biological Systems
Pianowski, Z. L. (2019) · Chemistry – A European Journal · doi:10.1002/chem.201805814 · Cited by 328
Mechanochemical bond scission for the activation of drugs
Huo, S., Zhao, P., Shi, Z., Zou, M., Yang, X., Warszawik, E., Loznik, M., Göstl, R., & Herrmann, A. (2021) · Nature Chemistry · doi:10.1038/s41557-020-00624-8 · Cited by 322
Helmy, S., Oh, S., Leibfarth, F. A., Hawker, C. J., & Read de Alaniz, J. (2014) · The Journal of Organic Chemistry · doi:10.1021/jo502206g · Cited by 283
Near‐IR Photochemistry for Biology: Exploiting the Optical Window of Tissue
Alabugin, A. (2019) · Photochemistry and Photobiology · doi:10.1111/php.13068 · Cited by 70
Reversible Control of Native GluN2B-Containing NMDA Receptors with Visible Light
Geoffroy, C., Berraud-Pache, R., Chéron, N., McCort-Tranchepain, I., Doria, J., Paoletti, P., & Mony, L. (2024) · ACS Chemical Neuroscience · doi:10.1021/acschemneuro.4c00247 · Cited by 9
Metadata
- Authors
- Velema, W. A., Szymanski, W., & Feringa, B. L.
- Venue
- Journal of the American Chemical Society
- Publisher
- American Chemical Society (ACS)
- Published
- 2014-02-04
- Volume
- 136
- Issue
- 6
- Pages
- 2178-2191
- ISSN
- 0002-7863 (ISSN-L)
- 1520-5126
- OpenAlex
- W2330760879
- Cited by
- 1,178
- References
- 4
- FWCI
- 36.48
- Type
- journal article
- Language
- en
- Open access
- green
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