Defining the Stoichiometry and Cargo Load of Viral and Bacterial Nanoparticles by Orbitrap Mass Spectrometry
Snijder, Joost, van de Waterbeemd, Michiel, Damoc, Eugen, Denisov, Eduard, Grinfeld, Dmitry, Bennett, Antonette, Agbandje-McKenna, Mavis, Makarov, Alexander +1 more·2014·Journal of the American Chemical Society
Cited by (168)
Items 101–168 of 168
- Role of the membrane-associated accessory protein (MAAP) in adeno-associated virus (AAV) infectionÇağla Aksu Küz, Kang Ning, Siyuan Hao, Fang Cheng, Jianming Qiu · 2024 · Journal of Virology
- AAV6 K531 serves a dual function in selective receptor and antibody ADK6 recognitionAntonette D. Bennett, Kristine Wong, Jordyn Lewis, Yu-Shan Tseng, James Kennon Smith, Paul R. Chipman, ROBERT V. McKENNA, Richard Jude Samulski, Jürgen A. Kleinschmidt, Mavis Agbandje‐McKenna · 2018 · Virology
- Recombinant Expression of the Full-length Ectodomain of LDL Receptor-related Protein 1 (LRP1) Unravels pH-dependent Conformational Changes and the Stoichiometry of Binding with Receptor-associated Protein (RAP)Camilla De Nardis, Philip Lössl, Maartje van den Biggelaar, Pramod Kumar Madoori, Nadia O. L. Leloup, Koen Mertens, Albert J. R. Heck, Piet Gros · 2016 · Journal of Biological Chemistry
- Effects of Molecular Size on Resolution in Charge Detection Mass SpectrometryConner C. Harper, Zachary M. Miller, Hyun‐Cheol Lee, Amanda J. Bischoff, Matthew B. Francis, David V. Schaffer, Evan R. Williams · 2022 · Analytical Chemistry
- Mass spectrometry in gene therapy: Challenges and opportunities for AAV analysisMahalia A. C. Serrano, Ran Furman, Guodong Chen, Liyuan Tao · 2022 · Drug Discovery Today
- Developments in FTICR-MS and Its Potential for Body Fluid SignaturesSimone Nicolardi, Bogdan Bogdanov, André M. Deelder, Magnus Palmblad, Yuri E. M. van der Burgt · 2015 · International Journal of Molecular Sciences
- Application of Size Exclusion Chromatography with Multiangle Light Scattering in the Analytical Development of a Preclinical Stage Gene Therapy ProgramBryan Troxell, I-Wei Tsai, Kinjal Shah, Christopher I. Knuckles, Sarah Shelton, Kate Lindsey, Selene M. Barbosa Cardenas, Taylor Roberts · 2023 · Human Gene Therapy
- Site‐specific functionality and tryptophan mimicry of lipidation in tetraspanin CD9Viviana Neviani, Sjoerd J. van Deventer, Tobias P. Wörner, Katerina T. Xenaki, Michiel van de Waterbeemd, Remco N. P. Rodenburg, Inge M. N. Wortel, Jeroen K. Kuiper, Sofie Huisman, Joke C. M. Granneman et al. · 2020 · FEBS Journal
- Multiparametric domain insertional profiling of adeno-associated virus VP1Mareike Daniela Hoffmann, Alina C. Zdechlik, Yungui He, David M. Nedrud, George Aslanidi, Wendy Ryan Gordon, Daniel Schmidt · 2023 · Molecular Therapy — Methods & Clinical Development
- Advances and opportunities in process analytical technologies for viral vector manufacturingSobhana Alekhya Sripada, Mahshid Hosseini, Srivatsan Ramesh, Junhyeong Wang, Kimberly Ritola, Stefano Menegatti, Michael Angelo-Anthony Daniele · 2024 · Biotechnology Advances
- Mass Determination of Entire Amyloid Fibrils by Using Mass SpectrometryTristan Doussineau, Carole Mathevon, Lucie Altamura, Charlotte Vendrely, Philippe Dugourd, Vincent Forge, Rodolphe Antoine · 2015 · Angewandte Chemie
- Fundamentals of Orbitrap analyzerAlexander Makarov, Dmitry Grinfeld, Konstantin Ayzikov · 2019 · Elsevier eBooks
- Structural Study of Aavrh.10 Receptor and Antibody InteractionsMario Mietzsch, Jennifer C. Yu, Jane Hsi, Paul R. Chipman, Felix Broecker, Zhang Fuming, Robert J. Linhardt, Peter H. Seeberger, Regine Heilbronn, Robert McKenna et al. · 2021 · Journal of Virology
- Evolution of Mass Spectrometers for High m/z Biological Ion Formation, Transmission, Analysis and Detection: A Personal PerspectiveIain D. G. Campuzano, Joseph A. Loo · 2025 · Journal of the American Society for Mass Spectrometry
- Structural characterization of a bat Adeno-associated virus capsidMario Mietzsch, Ya Li, Justin J. Kurian, James Kennon Smith, Paul R. Chipman, ROBERT V. McKENNA, Lin Yang, Mavis Agbandje‐McKenna · 2020 · Journal of Structural Biology
- Structural and Biophysical Analysis of Adeno-Associated Virus Serotype 2 Capsid Assembly VariantsAntonette D. Bennett, Joseph Gargas, Austin Kansol, Jordyn Lewis, Jane Hsi, Joshua A. Hull, Mario Mietzsch, Lawrence J. Tartaglia, Nicholas Muzyczka, Nilakshee Bhattacharya et al. · 2023 · Journal of Virology
- N-glycomic profiling of capsid proteins from Adeno-Associated Virus serotypesYongjing Xie, Michael Butler · 2023 · Glycobiology
- Mass spectrometry-based studies of virus assemblyAlison E. Ashcroft · 2019 · Current Opinion in Virology
- Structural and antigenic characterization of the avian adeno-associated virus capsidJane Hsi, M. Mietzsch, P. Chipman, S. Afione, A. Zeher, Rick K. Huang, J. Chiorini, Robert McKenna · 2023 · Journal of Virology
- The Expression and Function of the Small Nonstructural Proteins of Adeno-Associated Viruses (AAVs)Çağla Aksu Küz, Shane McFarlin, Jianming Qiu · 2024 · Viruses
- Molecular weight determination of adeno‐associate virus serotype 8 virus‐like particle either carrying or lacking genome via native nES gas‐phase electrophoretic molecular mobility analysis and nESI QRTOF mass spectrometrySamuele Zoratto, Victor U. Weiss, Jerre van der Horst, Jan Commandeur, Carsten Buengener, Alexandra Foettinger‐Vacha, Robert Pletzenauer, Michael Graninger, Guenter Allmaier · 2021 · Journal of Mass Spectrometry
- Affinity chromatography for virus-like particle manufacturing: Challenges, solutions, and perspectivesJing Ma, Zengquan Tian, Qinghong Shi, Xiaoyan Dong, Yan Ping Sun · 2024 · Journal of Chromatography A
- Unlocking precision gene therapy: harnessing AAV tropism with nanobody swapping at capsid hotspotsMareike Daniela Hoffmann, Joseph P. Gallant, Aaron Matthew LeBeau, Daniel Schmidt · 2024 · NAR Molecular Medicine
- Comparative structural, biophysical, and receptor binding study of true type and wild type AAV2Antonette D. Bennett, Joshua A. Hull, Nelly Jolinon, Julie Tordo, Katie Moss, Enswert Binns, Mario Mietzsch, Cathleen Hagemann, R. Michael Linden, Andrea Serio et al. · 2021 · Journal of Structural Biology
- Capsid Structure of Aleutian Mink Disease Virus and Human Parvovirus 4: New Faces in the Parvovirus Family PortraitRenuk Lakshmanan, Mario Mietzsch, Alberto Jimenez Ybargollin, Paul R. Chipman, Xiaofeng Fu, Jianming Qiu, Maria Söderlund‐Venermo, ROBERT V. McKENNA · 2022 · Viruses
- Partial genome content within rAAVs impacts performance in a cell assay-dependent mannerBryan Troxell, Sarah L. Jaslow, I-Wei Tsai, Chelsea S. Sullivan, Benjamin E. Draper, Martin F. Jarrold, Kate Lindsey, Levi Blue · 2023 · Molecular Therapy — Methods & Clinical Development
- Square Membrane Resonators Supporting Degenerate Modes of Vibration for High-Throughput Mass Spectrometry of Single Bacterial CellsAdrián Sanz-Jiménez, Jose Jaime Ruz, Eduardo Gil-Santos, Óscar Malvar, Sergio García‐López, Priscila M. Kosaka, Álvaro Cano, Montserrat Calleja, Javier Tamayo · 2023 · ACS Sensors
- Higher-Order Structure of Adeno-Associated Virus Serotype 8 by Hydrogen/Deuterium Exchange Mass SpectrometryTomohiko Ikeda, Yuki Yamaguchi, Hiroaki Oyama, Aoba Matsushita, Yasuo Tsunaka, Mitsuko Fukuhara, Tetsuo Torisu, Susumu Uchiyama · 2024 · Viruses
- Degronomics: Mapping the Interacting Peptidome of a Ubiquitin Ligase Using an Integrative Mass Spectrometry StrategyCanzani, Daniele, Rusnac, Domniţa-Valeria, Zheng, Ning, Bush, Matthew F. · 2019 · Analytical Chemistry
- Toward Nanopore Electrospray Mass Spectrometry: Nanopore Effects in the Analysis of BacteriaYu Zhang, Yang Tang, Congrui Tan, Wei Liang Xu · 2020 · ACS Central Science
- Mass Spectrometry for Cancer BiomarkersRadu Albulescu, Andrei‐José Petrescu, Mirela Sârbu, Alice Grigore, Raluca Ică, Cristian V. A. Munteanu, Adrian Albulescu, Ioana V. Militaru, Alina Diana Zamfir, Stefana Maria Petrescu et al. · 2019 · IntechOpen eBooks
- Identification of the role of SNARE proteins in rAAV vector production through interaction with the viral MAAPÇağla Aksu Küz, Kang Ning, Siyuan Hao, Shane McFarlin, Xiu Juan Zhang, Fang Cheng, Jianming Qiu · 2024 · Molecular Therapy — Methods & Clinical Development
- The amazing AAV capsids: Into the structure-verseJane Hsi, Mario Mietzsch, ROBERT V. McKENNA · 2025 · Molecular Therapy — Methods & Clinical Development
- Electrospray Ionization-Mass Spectrometry of Synthetic Polymers Functionalized with Carboxylic Acid End-GroupsTobias Nitsche, Margaret M. Sheil, James P. Blinco, Christopher Barner‐Kowollik, Stephen J. Blanksby · 2021 · Journal of the American Society for Mass Spectrometry
- Stochastic assembly of biomacromolecular complexes: impact and implications on charge interpretation in native mass spectrometryVictor C. Yin, Paul W. A. Devine, Janet C. Saunders, Arjan Barendregt, Fiona S. Cusdin, Alexandra Ristani, Alistair R. Hines, Sam Shepherd, Marcin Dembek, Claire Dobson et al. · 2023 · Chemical Science
- Emerging native Orbitrap mass spectrometry for probing higher-order structures of proteins: Recent progress and applicationsLinsen Li, Ying Zhang, Yueguang Lv, Feng Qu, Qiang Ma · 2023 · TrAC Trends in Analytical Chemistry
- Staying Alive: Measuring Intact Viable Microbes with Electrospray Ionization Mass SpectrometryErica M. Forsberg, Mingliang Fang, Gary E. Siuzdak · 2016 · Journal of the American Society for Mass Spectrometry
- High‐Mass MALDI ‐ MS Analysis for the Investigation of Protein Encapsulation within an Engineered Capsid Forming ProteinKatharina Root, Raphael Frey, Donald Hilvert, Renato Zenobi · 2017 · Helvetica Chimica Acta
- Further insights from structural mass spectrometry into endocytosis adaptor protein assembliesJohannes Heidemann, Knut Kölbel, Albert Konijnenberg, Jeroen F. van Dyck, María García-Alai, Rob Meijers, Frank Sobott, Charlotte Uetrecht · 2019 · International Journal of Mass Spectrometry
- Propagating Error through Traveling-Wave Ion Mobility CalibrationAlexis N. Edwards, Hien M. Tran, Elyssia S. Gallagher · 2021 · Journal of the American Society for Mass Spectrometry
- The progress of the cyclic strategy in separation and detectionBaisen Chen, Ziwang Liu, Xiaoshuai Yang, Xiaolu Zhou, Ling Xia, Gongke Li · 2025 · Chemical Science
- Proteomics Technologies and ApplicationsIbrokhim Yulchievich Abdurakhmonov · 2019 · IntechOpen eBooks
- First 20 Years of Orbitrap Mass Spectrometry as the Mainstream Analytical TechniqueAlexander Makarov · 2026 · Mass Spectrometry Reviews
- Research Status and Applications of Adeno‐Associated VirusKe Xia, S. Liu, Zhenkun Wu, Jian‐Hui Jiang · 2024 · ChemBioChem
- Microfluidic AAV Purity Characterization: New Insights into Serotype and Sample Treatment VariabilityAdriana Coll De Peña, James D. White, Dipti R. Mehta, Menel Ben Frej, Anubhav Tripathi · 2024 · ACS Omega
- Spectral Interferences Impede the High-Resolution Mass Analysis of Recombinant Adeno-Associated VirusesVictor C. Yin, Paul W. A. Devine, Janet C. Saunders, Alistair R. Hines, Sam Shepherd, Marcin Dembek, Claire Dobson, Joost Snijder, Nicholas J. Bond, Albert J. R. Heck · 2022 · bioRxiv (Cold Spring Harbor Laboratory)
- Development of LC-MS methods for AAV capsid protein quantification and host cell protein profilingTheodoros Kontogiannis, Christopher McElroy, Milena Quaglia, Carole A. Foy, Alexandra S. Whale, Julian H. Braybrook, Christopher Mark Smales · 2025 · Molecular Therapy — Methods & Clinical Development
- Twenty years of human bocavirus research: from an unculturable virus of unclear pathogenicity to a culturable human pathogen and gene therapy vector candidateOliver Schildgen, Jianming Qiu, Mario Mietzsch, Tobias Allander, Tuomas T. Jartti, Verena Schildgen, Dirk Grimm, Maria Söderlund‐Venermo · 2025 · Clinical Microbiology Reviews
- Extending the mass-to-charge scannable range of a linear ion trap mass spectrometer through quadrupolar direct current scanDi Zhang, You Jiang, Shiying Chu, Xinhua Dai, Xiang Fang · 2021 · International Journal of Mass Spectrometry
- Resolving heterogeneous high-mass macromolecular machineries by Orbitrap-based single particle charge detection mass spectrometryTobias P. Wörner, Joost Snijder, Antonette D. Bennett, Mavis Agbandje‐McKenna, Alexander Makarov, Albert J. R. Heck · 2019 · bioRxiv (Cold Spring Harbor Laboratory)
- Variable Assembly and Procapsid Binding of Bacteriophage P22 Terminase Subunits in SolutionJulia Elise Cabral, Yanfei Qiu, Albert J. R. Heck, Reginald McNulty · 2024 · Pathogens
- Sequestered: Design and Construction of Synthetic OrganellesThawatchai Chaijarasphong, David F. Savage · 2018
- Molecular Packaging of Biocatalysts Using a Robust Protein CageNikola Lončar, Henriëtte J. Rozeboom, Linda Elise Franken, Marc C. A. Stuart, Marco W. Fraaije · 2020 · ChemRxiv
- Differential Large and Small Terminase Subunit Assembly Mediate Bacteriophage P22 Genome PackagingJulia Elise Cabral, Yanfei Qiu, Abert J.R. Heck, Reginald McNulty · 2023 · Preprints.org
- The Role of Assembly-Activating Protein in the Capsid Assembly of Different Adeno-Associated Virus SerotypesLauriel F. Earley · 2016
- Supercharging methods for improving analysis and detection of proteins by electrospray ionization mass spectrometryCatherine C. Going · 2015 · eScholarship (California Digital Library)
- Molecular Packaging of Biocatalysts Using a Robust Protein CageNikola Lončar, Henriëtte J. Rozeboom, Linda Elise Franken, Marc C. A. Stuart, Marco W. Fraaije · 2020 · ChemRxiv
- Technological developments in mass spectrometry towards molecular structural elucidation of macromolecular assembliesAnjusha Mathew · 2023
- Encapsulins: structure, properties, application in biotechnologyNelly S. Chmelyuk, Vera V. Oda, Anna N. Gabashvili, Maxim A. Abakumov · 2023 · Biochemistry (Moscow)
- Protein Carrier AAVMareike Daniela Hoffmann, Ryan James Sorensen, Ajay Extross, Yungui He, Daniel Schmidt · 2024 · bioRxiv (Cold Spring Harbor Laboratory)
- Amdoparvoviruses. Part 1. The global taxonomic analysis of Aleutian mink disease virus strains and isolates is based on the phylogenetic analysis of full VP2 protein sequences.Irina M. Zyrianova · 2024 · Research Square
- Amdoparvoviruses. Part 1. Phylogenetic analysis of complete VP2 protein sequences provided support for a global taxonomic analysis of the Aleutian mink disease virusIrina M. Zyrianova · 2025 · AIMS Animal Science
- A Longitudinal 3D Live-Cell Imaging Platform to Uncover AAV Vector–Host Dynamics at Single-Cell ResolutionMarlies Leysen, Nicolas Peredo, Benjamin Pavie, Benjamien Moeyaert, Els Henckaerts · 2025 · International Journal of Molecular Sciences
- MS-based workflow for PTM profiling of rAAV capsid proteins to support bioprocess monitoring and developmentTomás M. Mateus, Sofia B. Carvalho, Bruno M. Alexandre, Ricardo A. Gomes, Patrícia Gomes‐Alves · 2026 · Journal of Biotechnology
- Characterization of rAAV vectors packaging in baculovirusinfected insect cellsMagalie Penaud‐Budloo · 2018 · theses.fr (ABES)
- High resolution ES-DMA quantifies AAV capsid DNA content by electrical mobility to mass correlationPreston Dennett, Lohra M. Young, Benjamin E. Draper, Jerome Schmitt, Martin F. Jarrold, Luis Javier Perez-Lorenzo · 2026 · Gene Therapy
- Modulating pressure in the Orbitrap improves sensitivity and mass resolution in charge detection mass spectrometryEduard H.T.M. Ebberink, Elena Giaretta, Arjan Barendregt, Jan Fiala, Victor C. Yin, Tobias P. Wörner, Kyle L. Fort, Alexander Makarov, Albert J. R. Heck · 2026 · Nature Communications
- Functional comparison of EncB and EncC cargo proteins in iron storage within the Myxococcus xanthus encapsulinHarry Benjamin McDowell, Thomas Walther, Egbert Hoiczyk · 2026 · FEBS Letters