The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Activatable Fluorescence/MRI Bimodal Platform for Tumor Cell Imaging via MnO2 Nanosheet–Aptamer Nanoprobe
Abstract
A novel dual-activatable fluorescence/MRI bimodal platform is designed for tumor cell imaging by using a redoxable manganese dioxide (MnO2) nanosheet-aptamer nanoprobe. The redoxable MnO2 nanosheet acts as a DNA nanocarrier, fluorescence quencher, and intracellular glutathione (GSH)-activated MRI contrast agent. In the absence of target cells, neither fluorescence signaling nor MRI contrast of the nanoprobe is activated. In the presence of target cells, the binding of aptamers to their targets weakens the adsorption of aptamers on the MnO2 nanosheets, causing partial fluorescence recovery, illuminating the target cells, and also facilitating the endocytosis of nanoprobes into target cells. After endocytosis, the reduction of MnO2 nanosheets by GSH further activates the fluorescence signals and generates large amounts of Mn(2+) ions suitable for MRI. This platform should facilitate the development of various dual-activatable fluorescence/MRI bimodalities for use in cells or in vivo.
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Citations
Cites
Multimodality Imaging Probes: Design and Challenges
Louie, A. (2010) · Chemical Reviews · doi:10.1021/cr9003538 · Cited by 1,044
Cited by
Fan, H., Yan, G., Zhao, Z., Hu, X., Zhang, W., Liu, H., Fu, X., Fu, T., Zhang, X., & Tan, W. (2016) · Angewandte Chemie International Edition · doi:10.1002/anie.201510748 · Cited by 567
Self-citationYan, R., Hu, Y., Liu, F., Wei, S., Fang, D., Shuhendler, A. J., Liu, H., Chen, H.-Y., & Ye, D. (2019) · Journal of the American Chemical Society · doi:10.1021/jacs.9b03649 · Cited by 389
Metalloimmunology: The metal ion-controlled immunity
(2020) · Advances in Immunology · doi:10.1016/bs.ai.2019.11.007 · Cited by 292
Dong, Z., Feng, L., Zhu, W., Sun, X., Gao, M., Zhao, H., Chao, Y., & Liu, Z. (2016) · Biomaterials · doi:10.1016/j.biomaterials.2016.09.025 · Cited by 284
Li, B., Gu, Z., Kurniawan, N., Chen, W., & Xu, Z. P. (2017) · Advanced Materials · doi:10.1002/adma.201700373 · Cited by 258
Metadata
- Authors
- Zhao, Z., Fan, H., Zhou, G., Bai, H., Liang, H., Wang, R., Zhang, X., & Tan, W.
- Venue
- Journal of the American Chemical Society
- Publisher
- American Chemical Society (ACS)
- Published
- 2014-07-31
- Volume
- 136
- Issue
- 32
- Pages
- 11220-11223
- ISSN
- 0002-7863 (ISSN-L)
- 1520-5126
- OpenAlex
- W2328216958
- Cited by
- 584
- References
- 1
- FWCI
- 24.17
- Type
- journal article
- Language
- en
- Open access
- closed
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