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Nanoscale Metal–Organic Framework for Highly Effective Photodynamic Therapy of Resistant Head and Neck Cancer
Open accessAbstract
Photodynamic therapy (PDT) is an effective anticancer procedure that relies on tumor localization of a photosensitizer followed by light activation to generate cytotoxic reactive oxygen species (e.g., (1)O2). Here we report the rational design of a Hf-porphyrin nanoscale metal-organic framework, DBP-UiO, as an exceptionally effective photosensitizer for PDT of resistant head and neck cancer. DBP-UiO efficiently generates (1)O2 owing to site isolation of porphyrin ligands, enhanced intersystem crossing by heavy Hf centers, and facile (1)O2 diffusion through porous DBP-UiO nanoplates. Consequently, DBP-UiO displayed greatly enhanced PDT efficacy both in vitro and in vivo, leading to complete tumor eradication in half of the mice receiving a single DBP-UiO dose and a single light exposure. NMOFs thus represent a new class of highly potent PDT agents and hold great promise in treating resistant cancers in the clinic.
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He, C., Lu, K., Liu, D., & Lin, W. (2014) · Journal of the American Chemical Society · doi:10.1021/ja4098862 · Cited by 885
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Cited by
Recent Strategies to Develop Innovative Photosensitizers for Enhanced Photodynamic Therapy
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Park, J., Jiang, Q., Feng, D., Mao, L., & Zhou, H.-C. (2016) · Journal of the American Chemical Society · doi:10.1021/jacs.6b00007 · Cited by 915
Metal–Organic-Framework-Based Materials for Antimicrobial Applications
Li, R., Chen, T., & Pan, X. (2021) · ACS Nano · doi:10.1021/acsnano.0c09617 · Cited by 555
Wang, C., Kaneti, Y. V., Bando, Y., Lin, J., Liu, C., Li, J., & Yamauchi, Y. (2018) · Materials Horizons · doi:10.1039/c8mh00133b · Cited by 533
Metal-organic frameworks for advanced drug delivery
He, S., Wu, L., Li, X., Sun, H., Xiong, T., Liu, J., Huang, C., Xu, H., Sun, H., Chen, W., et al. (2021) · Acta Pharmaceutica Sinica B · doi:10.1016/j.apsb.2021.03.019 · Cited by 528
Metadata
- Authors
- Lu, K., He, C., & Lin, W.
- Venue
- Journal of the American Chemical Society
- Publisher
- American Chemical Society (ACS)
- Published
- 2014-11-19
- Volume
- 136
- Issue
- 48
- Pages
- 16712-16715
- ISSN
- 0002-7863 (ISSN-L)
- 1520-5126
- OpenAlex
- W2042138520
- Cited by
- 745
- References
- 1
- FWCI
- 31.50
- Type
- journal article
- Language
- en
- Open access
- hybrid
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- Lu, K., He, C., & Lin, W. (2014). Nanoscale Metal–Organic Framework for Highly Effective Photodynamic Therapy of Resistant Head and Neck Cancer. Journal of the American Chemical Society. https://doi.org/10.1021/ja508679h
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