The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Inhibition of HIV Fusion with Multivalent Gold Nanoparticles
Open accessAbstract
The design and synthesis of a multivalent gold nanoparticle therapeutic is presented. SDC-1721, a fragment of the potent HIV inhibitor TAK-779, was synthesized and conjugated to 2.0 nm diameter gold nanoparticles. Free SDC-1721 had no inhibitory effect on HIV infection; however, the (SDC-1721)-gold nanoparticle conjugates displayed activity comparable to that of TAK-779. This result suggests that multivalent presentation of small molecules on gold nanoparticle surfaces can convert inactive drugs into potent therapeutics.
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Cites
Wei, X., Decker, J. M., Liu, H., Zhang, Z., Arani, R. B., Kilby, J. M., Saag, M. S., Wu, X., Shaw, G. M., & Kappes, J. C. (2002) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.46.6.1896-1905.2002 · Cited by 1,569
Cited by
Gold Nanoparticles for Biology and Medicine
Giljohann, D. A., Seferos, D. S., Daniel, W. L., Massich, M. D., Patel, P. C., & Mirkin, C. A. (2010) · Angewandte Chemie International Edition · doi:10.1002/anie.200904359 · Cited by 2,356
The gold–sulfur interface at the nanoscale
Häkkinen, H. (2012) · Nature Chemistry · doi:10.1038/nchem.1352 · Cited by 1,727
Intrinsic therapeutic applications of noble metal nanoparticles: past, present and future
Arvizo, R. R., Bhattacharyya, S., Kudgus, R. A., Giri, K., Bhattacharya, R., & Mukherjee, P. (2012) · Chemical Society Reviews · doi:10.1039/c2cs15355f · Cited by 866
Zhao, Y., Tian, Y., Cui, Y., Liu, W., Ma, W., & Jiang, X. (2010) · Journal of the American Chemical Society · doi:10.1021/ja1028843 · Cited by 592
Gold Nanoparticles for Nucleic Acid Delivery
Ding, Y., Jiang, Z., Saha, K., Kim, C. S., Kim, S. T., Landis, R. F., & Rotello, V. M. (2014) · Molecular Therapy · doi:10.1038/mt.2014.30 · Cited by 521
Metadata
- Authors
- Bowman, M.-C., Ballard, T. E., Ackerson, C. J., Feldheim, D. L., Margolis, D. M., & Melander, C.
- Venue
- Journal of the American Chemical Society
- Publisher
- American Chemical Society (ACS)
- Published
- 2008-05-13
- Volume
- 130
- Issue
- 22
- Pages
- 6896-6897
- ISSN
- 0002-7863 (ISSN-L)
- 1520-5126
- OpenAlex
- W2050307916
- Cited by
- 371
- References
- 1
- FWCI
- 10.51
- Type
- journal article
- Language
- en
- Open access
- green
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