The DOI matches its Crossref record; 45 of the 45 references it cites were found in a registry or an index.
Small Molecule-Capped Gold Nanoparticles as Potent Antibacterial Agents That Target Gram-Negative Bacteria
Abstract
This report illustrates a new strategy in designing antibacterial agents--a series of commercially available compounds, amino-substituted pyrimidines (themselves completely inactive as antibiotics), when presented on gold nanoparticles (NPs), show antibacterial activities against multidrug-resistant clinical isolates, without external sources of energy such as IR. These pyrimidine-capped gold NPs exert their antibiotic actions via sequestration of magnesium or calcium ions to disrupt the bacterial cell membrane, resulting in leakage of cytoplasmic contents including nucleic acids from compromised cell membranes, and via interaction with DNA and inhibition of protein synthesis by internalized NPs. These amino-substituted pyrimidine-capped gold NPs induce bacterial resistance more slowly compared with conventional, small-molecule antibiotics and appear harmless to human cells; these NPs may hence be useful for clinical applications.
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Cited by
Combatting antibiotic-resistant bacteria using nanomaterials
Gupta, A., Mumtaz, S., Li, C.-H., Hussain, I., & Rotello, V. M. (2019) · Chemical Society Reviews · doi:10.1039/c7cs00748e · Cited by 1,115
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Alternative Antimicrobial Approach: Nano-Antimicrobial Materials
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Metadata
- Authors
- Zhao, Y., Tian, Y., Cui, Y., Liu, W., Ma, W., & Jiang, X.
- Venue
- Journal of the American Chemical Society
- Publisher
- American Chemical Society (ACS)
- Published
- 2010-08-13
- Volume
- 132
- Issue
- 35
- Pages
- 12349-12356
- ISSN
- 0002-7863 (ISSN-L)
- 1520-5126
- OpenAlex
- W2083081255
- Cited by
- 592
- References
- 45
- FWCI
- 6.18
- Type
- journal article
- Language
- en
- Open access
- closed
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- Zhao, Y., Tian, Y., Cui, Y., Liu, W., Ma, W., & Jiang, X. (2010). Small Molecule-Capped Gold Nanoparticles as Potent Antibacterial Agents That Target Gram-Negative Bacteria. Journal of the American Chemical Society. https://doi.org/10.1021/ja1028843
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