The DOI matches its Crossref record; 22 of the 22 references it cites were found in a registry or an index.
Structural Basis of DNA Quadruplex Recognition by an Acridine Drug
Abstract
The crystal structure of a complex between the bimolecular human telomeric quadruplex d(TAGGGTTAGGGT)2 and the experimental anticancer drug BRACO-19, has been determined, to 2.5 A resolution. The binding site for the BRACO-19 molecule is at the interface of two parallel-folded quadruplexes, sandwiched between a G-tetrad surface and a TATA tetrad, and held in the site by networks of water molecules. The structure rationalizes the existing structure-activity data and provides a starting-point for the structure-based design of quadruplex-binding ligands
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Cites
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Cited by
Chemistry in human telomere biology: structure, function and targeting of telomere DNA/RNA
Xu, Y. (2011) · Chemical Society Reviews · doi:10.1039/c0cs00134a · Cited by 323
Metadata
- Authors
- Campbell, N. H., Parkinson, G. N., Reszka, A. P., & Neidle, S.
- Venue
- Journal of the American Chemical Society
- Publisher
- American Chemical Society (ACS)
- Published
- 2008-05-01
- Volume
- 130
- Issue
- 21
- Pages
- 6722-6724
- ISSN
- 0002-7863 (ISSN-L)
- 1520-5126
- OpenAlex
- W2028526843
- Cited by
- 326
- References
- 22
- FWCI
- 10.42
- Type
- journal article
- Language
- en
- Open access
- closed
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