The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
A One-Step Highly Sensitive Method for DNA Detection Using Dynamic Light Scattering
Open accessAbstract
A one-step homogeneous DNA detection method with high sensitivity was developed using gold nanoparticles (AuNPs) coupled with dynamic light scattering (DLS) measurement. Citrate-protected AuNPs with a diameter of 30 nm were first functionalized with two sets of single-stranded DNA probes and then used as optical probes for DNA detection. In the presence of target DNA, the hybridization between target DNA and the two nanoparticle probes caused the formation of nanoparticle dimers, trimers, and oligomers. As a result, the nanoparticle aggregation increased the average diameter of the whole nanoparticle population, which can be monitored simply by DLS measurement. A quantitative correlation can be established between the average diameter of the nanoparticles and the target DNA concentration. This DLS-based assay is extremely easy to conduct and requires no additional separation and amplification steps. The detection limit is around 1 pM, which is 4 orders of magnitude better than that of light-absorption-based methods. Single base pair mismatched DNAs can be readily discriminated from perfectly matched target DNAs using this assay.
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Cites
Nanostructures in Biodiagnostics
Rosi, N. L., & Mirkin, C. A. (2005) · Chemical Reviews · doi:10.1021/cr030067f · Cited by 4,603
Cited by
Wang, Z., & Ma, L. (2009) · Coordination Chemistry Reviews · doi:10.1016/j.ccr.2009.01.005 · Cited by 383
Xu, W., Xue, X., Li, T., Zeng, H., & Liu, X. (2009) · Angewandte Chemie International Edition · doi:10.1002/anie.200901772 · Cited by 382
Self-citationZheng, T., Bott, S., & Huo, Q. (2016) · ACS Applied Materials & Interfaces · doi:10.1021/acsami.6b06903 · Cited by 285
Self-citationGold nanoparticles: an era in bionanotechnology
Kumar, D., Saini, N., Jain, N., Sareen, R., & Pandit, V. (2013) · Expert Opinion on Drug Delivery · doi:10.1517/17425247.2013.749854 · Cited by 96
Metadata
- Authors
- Dai, Q., Liu, X., Coutts, J., Austin, L., & Huo, Q.
- Venue
- Journal of the American Chemical Society
- Publisher
- American Chemical Society (ACS)
- Published
- 2008-06-10
- Volume
- 130
- Issue
- 26
- Pages
- 8138-8139
- ISSN
- 0002-7863 (ISSN-L)
- 1520-5126
- OpenAlex
- W2042823734
- Cited by
- 187
- References
- 1
- FWCI
- 8.07
- Type
- journal article
- Language
- en
- Open access
- green
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