The DOI matches its Crossref record; 13 of the 13 references it cites were found in a registry or an index.
Nanoscale Coordination Polymers for Platinum-Based Anticancer Drug Delivery
Abstract
Pt-containing nanoscale coordination polymer (NCP) particles with the formula of Tb2(DSCP)3(H2O)12 (where DSCP represents disuccinatocisplatin), NCP-1, were precipitated from an aqueous solution of Tb3+ ions and DSCP bridging ligands via the addition of a poor solvent. SEM and TEM images showed that as-synthesized NCP-1 exhibited a spherical morphology with a DLS diameter of 58.3 +/- 11.3 nm. NCP-1 particles were stabilized against rapid dissolution in water by encapsulation in shells of amorphous silica. The resulting silica-coated particles NCP-1' exhibited significantly longer half-lives for DSCP release from the particles (a t1/2 of 9 h for NCP-1' with 7 nm silica coating vs t1/2 of 1 h for as-synthesized NCP-1). In vitro cancer cell cytotoxicity assays with the human colon carcinoma cell line (HT-29) showed that internalized NCP-1' particles readily released the DSCP moieties which were presumably reduced to cytotoxic Pt(II) species to give the Pt-containing NCPs anticancer efficacy superior to the cisplatin standard. The generality of this degradable nanoparticle formulation should allow for the design of NCPs as effective delivery vehicles for a variety of biologically and medically important cargoes such as therapeutic and imaging agents.
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Self-citationChemically tailorable colloidal particles from infinite coordination polymers
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Cited by
Platinum-Based Nanostructured Materials: Synthesis, Properties, and Applications
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Infinite coordination polymer nano- and microparticle structures
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Metadata
- Authors
- Rieter, W. J., Pott, K. M., Taylor, K. M. L., & Lin, W.
- Venue
- Journal of the American Chemical Society
- Publisher
- American Chemical Society (ACS)
- Published
- 2008-08-08
- Volume
- 130
- Issue
- 35
- Pages
- 11584-11585
- ISSN
- 0002-7863 (ISSN-L)
- 1520-5126
- OpenAlex
- W1968377063
- Cited by
- 803
- References
- 13
- FWCI
- 23.56
- Type
- journal article
- Language
- en
- Open access
- closed
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