The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.
Photoinduced Intracellular Controlled Release Drug Delivery in Human Cells by Gold-Capped Mesoporous Silica Nanosphere
Abstract
A gold nanoparticle (AuNP)-capped mesoporous silica nanosphere (MSN)-based intracellular drug delivery system (PR-AuNPs-MSN) for the photoinduced controlled release of an anticancer drug, paclitaxel, inside of human fibroblast and liver cells was synthesized and characterized. We found that the mesopores of MSN could be efficiently capped by the photoresponsive AuNPs without leaking the toxic drug, paclitaxel, inside of live human cells. This "zero premature release" characteristic is of importance for delivery of toxic drugs in chemotherapy. Furthermore, we demonstrated that the cargo-release property of this PR-AuNPs-MSN system could be easily controlled by low-power photoirradiation under biocompatible and physiological conditions. We envision that our results would play a significant role in designing new generations of carrier materials for intracellular delivery of a variety of hydrophobic toxic drugs.
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Cites
Mesoporous silica nanoparticles for drug delivery and biosensing applications
Slowing, I. I., Trewyn, B. G., Giri, S., & Lin, V. S. ‐. (2007) · Advanced Functional Materials · doi:10.1002/adfm.200601191 · Cited by 1,699
Self-citationPhoto-Driven Expulsion of Molecules from Mesostructured Silica Nanoparticles
Angelos, S., Choi, E., Vögtle, F., De Cola, L., & Zink, J. I. (2007) · The Journal of Physical Chemistry C · doi:10.1021/jp070721l · Cited by 227
Cited by
Stimuli-responsive nanocarriers for drug delivery
Mura, S., Nicolas, J., & Couvreur, P. (2013) · Nature Materials · doi:10.1038/nmat3776 · Cited by 6,289
Xia, T., Kovochich, M., Liong, M., Meng, H., Kabehie, S., George, S., Zink, J. I., & Nel, A. E. (2009) · ACS Nano · doi:10.1021/nn900918w · Cited by 933
Croissant, J. G., Fatieiev, Y., Almalik, A., & Khashab, N. M. (2018) · Advanced Healthcare Materials · doi:10.1002/adhm.201700831 · Cited by 594
Smart Drug Delivery Nanocarriers with Self‐Assembled DNA Nanostructures
Li, J., Fan, C., Pei, H., Shi, J., & Huang, Q. (2013) · Advanced Materials · doi:10.1002/adma.201300875 · Cited by 441
Zhang, Y., Zhan, X., Xiong, J., Peng, S., Huang, W., Joshi, R., Cai, Y., Liu, Y., Li, R., Yuan, K., et al. (2018) · Scientific Reports · doi:10.1038/s41598-018-26978-1 · Cited by 348
Metadata
- Authors
- Vivero-Escoto, J. L., Slowing, I. I., Wu, C.-W., & Lin, V. S.-Y.
- Venue
- Journal of the American Chemical Society
- Publisher
- American Chemical Society (ACS)
- Published
- 2009-02-24
- Volume
- 131
- Issue
- 10
- Pages
- 3462-3463
- ISSN
- 0002-7863 (ISSN-L)
- 1520-5126
- OpenAlex
- W2061214110
- Cited by
- 647
- References
- 2
- FWCI
- 24.75
- Type
- journal article
- Language
- en
- Open access
- closed
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- Vivero-Escoto, J. L., Slowing, I. I., Wu, C.-W., & Lin, V. S.-Y. (2009). Photoinduced Intracellular Controlled Release Drug Delivery in Human Cells by Gold-Capped Mesoporous Silica Nanosphere. Journal of the American Chemical Society. https://doi.org/10.1021/ja900025f
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