The DOI matches its Crossref record; 20 of the 20 references it cites were found in a registry or an index.
Dual Native Chemical Ligation at Lysine
Abstract
A thiol group introduced on the gamma-carbon of lysine mediates robust native chemical ligation at both the alpha- and epsilon-amines in two consecutive steps. Desulfurization then affords the final product, in which the lysine residue at the ligation site has an isopeptide bond on its side chain. The method is useful for the synthesis of proteins containing special post-translational modifications on lysine.
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Citations
Cites
Synthesis of Proteins by Native Chemical Ligation
Dawson, P. E., Muir, T. W., Clark-Lewis, I., & Kent, S. B. H. (1994) · Science · doi:10.1126/science.7973629 · Cited by 4,131
Synthesis of Native Proteins by Chemical Ligation
Dawson, P. E., & Kent, S. B. H. (2000) · Annual Review of Biochemistry · doi:10.1146/annurev.biochem.69.1.923 · Cited by 1,082
Total chemical synthesis of proteins
Kent, S. B. H. (2009) · Chem. Soc. Rev. · doi:10.1039/b700141j · Cited by 922
Wan, Q., & Danishefsky, S. J. (2007) · Angewandte Chemie International Edition · doi:10.1002/anie.200704195 · Cited by 878
Yan, L. Z., & Dawson, P. E. (2001) · Journal of the American Chemical Society · doi:10.1021/ja003265m · Cited by 661
Chemistry-Based Functional Proteomics Reveals Novel Members of the Deubiquitinating Enzyme Family
Borodovsky, A., Ovaa, H., Kolli, N., Gan-Erdene, T., Wilkinson, K. D., Ploegh, H. L., & Kessler, B. M. (2002) · Chemistry & Biology · doi:10.1016/s1074-5521(02)00248-x · Cited by 588
Native Chemical Ligation at Valine
Haase, C., Rohde, H., & Seitz, O. (2008) · Angewandte Chemie International Edition · doi:10.1002/anie.200801590 · Cited by 346
Chemical Synthesis of Proteins
Nilsson, B. L., Soellner, M. B., & Raines, R. T. (2005) · Annual Review of Biophysics and Biomolecular Structure · doi:10.1146/annurev.biophys.34.040204.144700 · Cited by 329
Native Chemical Ligation at Phenylalanine
Crich, D., & Banerjee, A. (2007) · Journal of the American Chemical Society · doi:10.1021/ja072804l · Cited by 282
Extending Synthetic Access to Proteins with a Removable Acyl Transfer Auxiliary
Offer, J., Boddy, C. N. C., & Dawson, P. E. (2002) · Journal of the American Chemical Society · doi:10.1021/ja016731w · Cited by 276
Cited by
Native Chemical Ligation and Extended Methods: Mechanisms, Catalysis, Scope, and Limitations
Agouridas, V., El Mahdi, O., Diemer, V., Cargoët, M., Monbaliu, J.-C. M., & Melnyk, O. (2019) · Chemical Reviews · doi:10.1021/acs.chemrev.8b00712 · Cited by 650
Rapid and efficient protein synthesis through expansion of the native chemical ligation concept
Kulkarni, S. S., Sayers, J., Premdjee, B., & Payne, R. J. (2018) · Nature Reviews Chemistry · doi:10.1038/s41570-018-0122 · Cited by 323
Histones: At the Crossroads of Peptide and Protein Chemistry
Müller, M. M., & Muir, T. W. (2015) · Chemical Reviews · doi:10.1021/cr5003529 · Cited by 247
Chemical Synthesis of Circular Proteins
Tam, J. P., & Wong, C. T. T. (2012) · Journal of Biological Chemistry · doi:10.1074/jbc.r111.323568 · Cited by 172
Metadata
- Authors
- Yang, R., Pasunooti, K. K., Li, F., Liu, X.-W., & Liu, C.-F.
- Venue
- Journal of the American Chemical Society
- Publisher
- American Chemical Society (ACS)
- Published
- 2009-09-03
- Volume
- 131
- Issue
- 38
- Pages
- 13592-13593
- ISSN
- 0002-7863 (ISSN-L)
- 1520-5126
- OpenAlex
- W2030818842
- Cited by
- 260
- References
- 20
- FWCI
- 10.56
- Type
- journal article
- Language
- en
- Open access
- closed
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- Yang, R., Pasunooti, K. K., Li, F., Liu, X.-W., & Liu, C.-F. (2009). Dual Native Chemical Ligation at Lysine. Journal of the American Chemical Society. https://doi.org/10.1021/ja905491p
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
