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Enzyme-Triggered Disassembly of Dendrimer-Based Amphiphilic Nanocontainers
Open accessAbstract
We demonstrate a new enzyme-induced disassembly of amphiphilic nanocontainers based on dendrimers. Disassembly and the ensuing release of noncovalently bound guest molecules are of great interest because of their implications in areas such as drug delivery and sensing. Achieving these with a protein as the stimulus is of even greater importance, because proteins are the primary indicators of biological imbalances. We achieved disassembly of the nanocontainers by disturbing the hydrophilic-lipophilic balance in the amphiphilic dendrimer building blocks.
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Cited by
Controlled drug delivery vehicles for cancer treatment and their performance
Senapati, S., Mahanta, A. K., Kumar, S., & Maiti, P. (2018) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-017-0004-3 · Cited by 2,167
Dendrimers Derived from 1 → 3 Branching Motifs
Newkome, G. R., & Shreiner, C. (2010) · Chemical Reviews · doi:10.1021/cr900341m · Cited by 347
Enzyme Sensitive Synthetic Polymer Micelles Based on the Azobenzene Motif
Rao, J., & Khan, A. (2013) · Journal of the American Chemical Society · doi:10.1021/ja407514z · Cited by 207
Metadata
- Authors
- Azagarsamy, M. A., Sokkalingam, P., & Thayumanavan, S.
- Venue
- Journal of the American Chemical Society
- Publisher
- American Chemical Society (ACS)
- Published
- 2009-09-16
- Volume
- 131
- Issue
- 40
- Pages
- 14184-14185
- ISSN
- 0002-7863 (ISSN-L)
- 1520-5126
- OpenAlex
- W1973501329
- Cited by
- 201
- References
- 0
- FWCI
- 14.21
- Type
- journal article
- Language
- en
- Open access
- green
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- Azagarsamy, M. A., Sokkalingam, P., & Thayumanavan, S. (2009). Enzyme-Triggered Disassembly of Dendrimer-Based Amphiphilic Nanocontainers. Journal of the American Chemical Society. https://doi.org/10.1021/ja906162u
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