Cited by 207Advanced Polymer Synthesis and CharacterizationNanoparticle-Based Drug DeliveryPhotochromic and Fluorescence Chemistry

Enzyme Sensitive Synthetic Polymer Micelles Based on the Azobenzene Motif

Rao, Jingyi, Khan, Anzar·2013·Journal of the American Chemical Society

Abstract

In this study, we investigate the potential of an artificial structural motif, azobenzene, in the preparation of enzyme sensitive polymeric nanostructures. For this purpose, an azobenzene linkage is established at the copolymer junction of an amphiphilic diblock copolymer. This polymer assembles into a micellar structure in water. Treatment with the enzyme azoreductase, in the presence of coenzyme NADPH, results in the cleavage of the azo-based copolymer junction and disruption of the micellar assembly. These results suggest that azobenezene is a useful non-natural structural motif for the preparation of enzyme responsive polymer nanoparticles. Due to the presence of azoreductase in the human intestine, such nanomaterials are anticipated to find applicability in the arena of colon-specific delivery systems.

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Crossref · 10.1021/ja407514z

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39 of 39 references verified0 citation errors · 0 not checkable

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  • Hyaluronidase, γ-Glutamyltranspeptidase, prostate-specific antigen, Trysin, β-galactosidase, Azoreductase, etc. are also used in enzyme-stimulated response smart nano-delivery systems.

    “In addition, hyaluronidase, γ-Glutamyltranspeptidase, prostate-specific antigen, Trysin, β-galactosidase, Azoreductase, etc. are also used in enzyme-stimulated response smart nano-delivery systems.157–162”

    From Smart nanoparticles for cancer therapy (2023) · cites this paper as [162]

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Authors
Rao, J., & Khan, A.
Affiliations
ETH Zurich (CH)
Corresponding author
Khan, Anzar
Venue
Journal of the American Chemical Society
Published
2013-09-13
Volume
135
Issue
38
Pages
14056-14059
ISSN
  • 0002-7863 (ISSN-L)
  • 1520-5126
OpenAlex
W2320976673
Cited by
207
References
39
Citations by year
2026: 6 · 2025: 11 · 2024: 7 · 2023: 17 · 2022: 12 · 2021: 18 · 2020: 25 · 2019: 23 · 2018: 18 · 2017: 18 · 2016: 19 · 2015: 19 · 2014: 13 · 2013: 1
FWCI
7.88
Type
journal article
Language
en
Open access
closed
Locations
  • Journal of the American Chemical Society (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Physical Sciences › Chemistry › Organic Chemistry › Advanced Polymer Synthesis and Characterization
  • Physical Sciences › Materials Science › Biomaterials › Nanoparticle-Based Drug Delivery
  • Physical Sciences › Materials Science › Materials Chemistry › Photochromic and Fluorescence Chemistry
Keywords
azobenzene, enzyme-responsive polymers, polymeric micelles, azoreductase, NADPH, amphiphilic diblock copolymers, colon-targeted drug delivery, polymeric nanoparticles
MeSH terms
Azo Compounds, Micelles, NAD, NADH, NADPH Oxidoreductases, Nitroreductases, Polyethylene Glycols, Polystyrenes

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