The DOI matches its Crossref record; 17 of the 17 references it cites were found in a registry or an index.
An Allosteric Dual-DNAzyme Unimolecular Probe for Colorimetric Detection of Copper(II)
Open accessAbstract
An effective dual-DNAzyme-based unimolecular probe design employing intramolecular signal transduction is demonstrated. The probe is composed of three domains: a DNA-cleaving DNAzyme, a substrate, and an HRP-mimicking DNAzyme. When the probe meets its target, cleavage of the substrate by the DNA-cleaving DNAzyme activates the HRP-mimicking DNAzyme, producing a colorimetric signal. The Cu(2+)-dependent DNAzyme engineered to demonstrate this design revealed a sensitivity corresponding to 65 ppb, which is sufficient to detect Cu(2+) in drinking water. The new probe has excellent selectivity toward Cu(2+). This three-component design is simple and easy to engineer. It may provide the basis for future development of other nucleic acid-based probes for toxicological and environmental monitoring.
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Cites
Breaker, R. R., & Joyce, G. F. (1994) · Chemistry & Biology · doi:10.1016/1074-5521(94)90014-0 · Cited by 1,476
A Colorimetric Lead Biosensor Using DNAzyme-Directed Assembly of Gold Nanoparticles
Liu, J., & Lu, Y. (2003) · Journal of the American Chemical Society · doi:10.1021/ja034775u · Cited by 1,347
Elements and Their Compounds in the Environment: Occurrence, Analysis and Biological Relevance
(2004) · Wiley eBooks · doi:10.1002/9783527619634 · Cited by 1,125
ENVIRONMENTAL COPPER: ITS DYNAMICS AND HUMAN EXPOSURE ISSUES
G. Georgopoulos, A. R. (2001) · Journal of Toxicology and Environmental Health, Part B · doi:10.1080/109374001753146207 · Cited by 628
Liu, J., & Lu, Y. (2007) · Angewandte Chemie International Edition · doi:10.1002/anie.200702006 · Cited by 593
Liu, J., Brown, A. K., Meng, X., Cropek, D. M., Istok, J. D., Watson, D. B., & Lu, Y. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0607875104 · Cited by 523
Li, J. (2000) · Nucleic Acids Research · doi:10.1093/nar/28.2.481 · Cited by 456
RNA Cleavage by a DNA Enzyme with Extended Chemical Functionality
Santoro, S. W., Joyce, G. F., Sakthivel, K., Gramatikova, S., & Barbas, C. F. (2000) · Journal of the American Chemical Society · doi:10.1021/ja993688s · Cited by 357
Pavlov, V., Xiao, Y., Gill, R., Dishon, A., Kotler, M., & Willner, I. (2004) · Analytical Chemistry · doi:10.1021/ac035219l · Cited by 351
A Highly Selective DNAzyme Sensor for Mercuric Ions
Hollenstein, M., Hipolito, C., Lam, C., Dietrich, D., & Perrin, D. M. (2008) · Angewandte Chemie International Edition · doi:10.1002/anie.200800960 · Cited by 317
Cited by
Photonic Nanosensor for Colorimetric Detection of Metal Ions
Yetisen, A. K., Montelongo, Y., Qasim, M. M., Butt, H., Wilkinson, T. D., Monteiro, M. J., & Yun, S. H. (2015) · Analytical Chemistry · doi:10.1021/ac504274q · Cited by 94
Metadata
- Authors
- Yin, B.-C., Ye, B.-C., Tan, W., Wang, H., & Xie, C.-C.
- Venue
- Journal of the American Chemical Society
- Publisher
- American Chemical Society (ACS)
- Published
- 2009-09-29
- Volume
- 131
- Issue
- 41
- Pages
- 14624-14625
- ISSN
- 0002-7863 (ISSN-L)
- 1520-5126
- OpenAlex
- W2092654845
- Cited by
- 287
- References
- 17
- FWCI
- 7.32
- Type
- journal article
- Language
- en
- Open access
- green
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