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Visualizing Ascorbate-Triggered Release of Labile Copper within Living Cells using a Ratiometric Fluorescent Sensor
Open accessAbstract
We present the synthesis, properties, and biological applications of Ratio-Coppersensor-1 (RCS1), a new water-soluble fluorescent sensor for ratiometric imaging of copper in living cells. RCS1 combines an asymmetric BODIPY reporter and thioether-based ligand receptor to provide high selectivity and sensitivity for Cu(+) over other biologically relevant metal ions, including Cu(2+) and Zn(2+), a ca. 20-fold fluorescence ratio change upon Cu(+) binding, and visible excitation and emission profiles compatible with standard fluorescence microscopy filter sets. Live-cell confocal microscopy experiments show that RCS1 is membrane-permeable and can sense changes in the levels of labile Cu(+) pools within living cells by ratiometric imaging, including expansion of endogenous stores of exchangeable intracellular Cu(+) triggered by ascorbate stimulation in kidney and brain cells.
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Neurodegenerative diseases and oxidative stress
Barnham, K. J., Masters, C. L., & Bush, A. I. (2004) · Nature Reviews Drug Discovery · doi:10.1038/nrd1330 · Cited by 3,683
Cited by
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Liu, X., Zhang, N., Bing, T., & Shangguan, D. (2014) · Analytical Chemistry · doi:10.1021/ac404236y · Cited by 308
Grover, K., Koblova, A., Pezacki, A. T., Chang, C. J., & New, E. J. (2024) · Chemical Reviews · doi:10.1021/acs.chemrev.3c00819 · Cited by 129
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Metadata
- Authors
- Domaille, D. W., Zeng, L., & Chang, C. J.
- Venue
- Journal of the American Chemical Society
- Publisher
- American Chemical Society (ACS)
- Published
- 2010-02-03
- Volume
- 132
- Issue
- 4
- Pages
- 1194-1195
- ISSN
- 0002-7863 (ISSN-L)
- 1520-5126
- OpenAlex
- W1997790931
- Cited by
- 352
- References
- 1
- FWCI
- 18.38
- Type
- journal article
- Language
- en
- Open access
- green
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- Domaille, D. W., Zeng, L., & Chang, C. J. (2010). Visualizing Ascorbate-Triggered Release of Labile Copper within Living Cells using a Ratiometric Fluorescent Sensor. Journal of the American Chemical Society. https://doi.org/10.1021/ja907778b
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