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Cited by 129Molecular Sensors and Ion DetectionAdvanced Fluorescence Microscopy TechniquesAnalytical Chemistry and Sensors

Small-Molecule Fluorescent Probes for Binding- and Activity-Based Sensing of Redox-Active Biological Metals

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Grover, Karandeep, Koblova, Alla, Pezacki, Aidan T., Chang, Christopher J., New, Elizabeth J.·2024·Chemical Reviews
DOI 10.1021/acs.chemrev.3c00819PMC PMC11485196
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Abstract

Although transition metals constitute less than 0.1% of the total mass within a human body, they have a substantial impact on fundamental biological processes across all kingdoms of life. Indeed, these nutrients play crucial roles in the physiological functions of enzymes, with the redox properties of many of these metals being essential to their activity. At the same time, imbalances in transition metal pools can be detrimental to health. Modern analytical techniques are helping to illuminate the workings of metal homeostasis at a molecular and atomic level, their spatial localization in real time, and the implications of metal dysregulation in disease pathogenesis. Fluorescence microscopy has proven to be one of the most promising non-invasive methods for studying metal pools in biological samples. The accuracy and sensitivity of bioimaging experiments are predominantly determined by the fluorescent metal-responsive sensor, highlighting the importance of rational probe design for such measurements. This review covers activity- and binding-based fluorescent metal sensors that have been applied to cellular studies. We focus on the essential redox-active metals: iron, copper, manganese, cobalt, chromium, and nickel. We aim to encourage further targeted efforts in developing innovative approaches to understanding the biological chemistry of redox-active metals.

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  • It is becoming possible to better visualize metals in motion with sensitive analytical tools, including an ever-increasing set of sensors to monitor chelatable metal ions in living cells.

    “Together with sensitive analytical tools, including an ever-increasing set of sensors to monitor chelatable metal ions in living cells,223−225 it is becoming possible to better visualize metals in motion.”

    From Metals in Motion: Understanding Labile Metal Pools in Bacteria (2025) · cites this paper as [224]

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  1. [1]Zoroddu MA; Aaseth J; Crisponi G; Medici S; Peana M; Nurchi VM The Essential Metals for Humans: A Brief Overview. J. Inorg. Biochem. 2019, 195, 120– 129. 30939379
  2. [3]Terwilliger NB Functional Adaptations of Oxygen-Transport Proteins. J. Exp. Biol. 1998, 201, 1085– 1098. 9510522
  3. [4]Murphy JM; Powell BA; Brumaghim JL Stability Constants of Bio-Relevant, Redox-Active Metals with Amino Acids: The Challenges of Weakly Binding Ligands. Coord. Chem. Rev. 2020, 412, 213253.
  4. [5]Kaur A; Lim Z; Yang K; New EJ Fluorescent Sensors for Biological Metal Ions. In Comprehensive Supramolecular Chemistry II; Elsevier Inc., 2017; Vol. 8, pp 295– 317.
  5. [6]Robinson NJ; Glasfeld A Metalation: Nature’s Challenge in Bioinorganic Chemistry. J. Biol. Inorg. Chem. 2020, 25, 543– 545. 32333210 PMC7239837
  6. [7]Barton JC; Edwards CQ; Acton RT HFE Gene: Structure, Function, Mutations, and Associated Iron Abnormalities. Gene 2015, 574, 179– 192. 26456104 PMC6660136
  7. [8]Peggion C; Scalcon V; Massimino ML; Nies K; Lopreiato R; Rigobello MP; Bertoli A SOD1 in ALS: Taking Stock in Pathogenic Mechanisms and the Role of Glial and Muscle Cells. Antioxidants 2022, 11, 614. 35453299 PMC9032988
  8. [9]Hare DJ; New EJ; De Jonge MD; McColl G Imaging Metals in Biology: Balancing Sensitivity, Selectivity and Spatial Resolution. Chem. Soc. Rev. 2015, 44, 5941– 5958. 26505053
  9. [10]Ackerman CM; Lee S; Chang CJ Analytical Methods for Imaging Metals in Biology: From Transition Metal Metabolism to Transition Metal Signaling. Anal. Chem. 2017, 89, 22– 41. 27976855 PMC5827935
  10. [11]Pröfrock D; Prange A Inductively Coupled Plasma-Mass Spectrometry (ICP-MS) for Quantitative Analysis in Environmental and Life Sciences: A Review of Challenges, Solutions, and Trends. Appl. Spectrosc. 2012, 66, 843– 868. 22800465
  11. [12]Gyngard F; Steinhauser ML Biological Explorations with Nanoscale Secondary Ion Mass Spectrometry. J. Anal. At. Spectrom. 2019, 34, 1534– 1545. 34054180 PMC8158666
  12. [13]Paunesku T; Vogt S; Maser J; Lai B; Woloschak G X-Ray Fluorescence Microprobe Imaging in Biology and Medicine. J. Cell. Biochem. 2006, 99, 1489– 1502. 17006954
  13. [14]Pearse A. G.Everson. Histochemistry; J.&A. Livingstone; 2nd edition; 1960.
  14. [15]Adair LD; Yang K; New EJ An Introduction to Small Molecule Fluorescent Sensors. In Molecular Fluorescent Sensors for Cellular Studies; John Wiley & Sons, Ltd, 2022; pp 1– 35.
  15. [16]Torres-Ocampo AP; Palmer AE Genetically Encoded Fluorescent Sensors for Metals in Biology. Curr. Opin. Chem. Biol. 2023, 74, 102284. 36917910 PMC10573084
  16. [17]Alvarez A; Costa-Fernández JM; Pereiro R; Sanz-Medel A; Salinas-Castillo A Fluorescent Conjugated Polymers for Chemical and Biochemical Sensing. TrAC, Trends Anal. Chem. 2011, 30, 1513– 1525.
  17. [18]Yoo D; Park Y; Cheon B; Park MH Carbon Dots as an Effective Fluorescent Sensing Platform for Metal Ion Detection. Nanoscale Res. Lett. 2019, 14, 1– 13. 31410663 PMC6692426
  18. [19]Zhang JJ; Cheng FF; Li JJ; Zhu JJ; Lu Y Fluorescent Nanoprobes for Sensing and Imaging of Metal Ions: Recent Advances and Future Perspectives. Nano Today 2016, 11, 309– 329. 27818705 PMC5089816
  19. [20]Ma DL; Ma VPY; Chan DSH; Leung KH; He HZ; Leung CH Recent Advances in Luminescent Heavy Metal Complexes for Sensing. Coord. Chem. Rev. 2012, 256, 3087– 3113.
  20. [21]Martinon TLM; Pierre VC Luminescent Lanthanide Probes for Cations and Anions: Promises, Compromises, and Caveats. Curr. Opin. Chem. Biol. 2023, 76, 102374. 37517109 PMC10529829
  21. [22]New EJ Harnessing the Potential of Small Molecule Intracellular Fluorescent Sensors. ACS Sens. 2016, 1, 328– 333.
  22. [23]Que EL; Domaille DW; Chang CJ Metals in Neurobiology: Probing Their Chemistry and Biology with Molecular Imaging. Chem. Rev. 2008, 108, 1517– 1549. 18426241
  23. [24]Carter KP; Young AM; Palmer AE Fluorescent Sensors for Measuring Metal Ions in Living Systems. Chem. Rev. 2014, 114, 4564– 4601. 24588137 PMC4096685
  24. [25]Lin J; Trinh N; New E Future Directions of Fluorescence Sensors for Cellular Studies. In Molecular Fluorescent Sensors for Cellular Studies; John Wiley & Sons, Ltd, 2022; pp 241– 284.
  25. [26]Czarnik AW Chemical Communication in Water Using Fluorescent Chemosensors. Acc. Chem. Res. 1994, 27, 302– 308.
  26. [27]Grynkiewicz G; Poenie M; Tsien RY A New Generation of Ca2+ Indicators with Greatly Improved Fluorescence Properties. J. Biol. Chem. 1985, 260, 3440– 3450. 3838314
  27. [28]Minta A; Tsien RY. Fluorescent Indicators for Cytosolic Sodium. J. Biol. Chem. 1989, 32, 19449– 19457. 2808435
  28. [29]Kaur A; Lim Z; Yang K; New EJ Fluorescent Sensors for Biological Metal Ions. Comprehensive Supramolecular Chemistry II. 2017, 8, 295– 317.
  29. [30]Chan J; Dodani SC; Chang CJ Reaction-Based Small-Molecule Fluorescent Probes for Chemoselective Bioimaging. Nat. Chem. 2012, 4, 973– 984. 23174976 PMC4096518
  30. [31]Bruemmer KJ; Crossley SWM; Chang CJ Activity-Based Sensing: A Synthetic Methods Approach for Selective Molecular Imaging and Beyond. Angew. Chem. Int. Ed. 2020, 59, 13734– 13762. PMC7665898 31605413
  31. [32]Bruemmer KJ; Crossley SWM; Chang CJ Activity-Based Sensing: A Synthetic Methods Approach for Selective Molecular Imaging and Beyond. Angew. Chem. Int. Ed. 2020, 59, 13734– 13762. PMC7665898 31605413
  32. [33]Lee MH; Kim JS; Sessler JL Small Molecule-Based Ratiometric Fluorescence Probes for Cations, Anions, and Biomolecules. Chem. Soc. Rev. 2015, 44, 4185– 4191. 25286013 PMC4387118
  33. [34]De Silva AP; Gunaratne HQN; Gunnlaugsson T; Huxley AJM; McCoy CP; Rademacher JT; Rice TE Signaling Recognition Events with Fluorescent Sensors and Switches. Chem. Rev. 1997, 97, 1515– 1566. 11851458
  34. [35]Daly B; Ling J; de Silva AP Current Developments in Fluorescent PET (Photoinduced Electron Transfer) Sensors and Switches. Chem. Soc. Rev. 2015, 44, 4203– 4211. 25695939
  35. [36]Bryan AJ; de Silva AP; De Silva SA; Rupasinghe RADD; Sandanayake KRAS Photo-Induced Electron Transfer as a General Design Logic for Fluorescent Molecular Sensors for Cations. Biosensors (Basel) 1989, 4, 169– 179.
  36. [37]Ustimova MA; Lebedeva A.Yu.; Fedorov Yu. V; Berdnikova DV; Fedorova OA. FRET-Based Metal Ion Sensing by a Crown-Containing Bisstyryl Dye. New J. Chem. 2018, 42, 7908– 7913.
  37. [38]Sedgwick AC; Wu L; Han HH; Bull SD; He XP; James TD; Sessler JL; Tang BZ; Tian H; Yoon J Excited-State Intramolecular Proton-Transfer (ESIPT) Based Fluorescence Sensors and Imaging Agents. Chem. Soc. Rev. 2018, 47, 8842– 8880. 30361725
  38. [39]Kim JS; Quang DT Calixarene-Derived Fluorescent Probes. Chem. Rev. 2007, 107, 3780– 3799. 17711335
  39. [40]Wong KL; Bünzli JCG; Tanner PA Quantum Yield and Brightness. J. Lumin. 2020, 224, 117256.
  40. [41]Zheng Q; Lavis LD Development of Photostable Fluorophores for Molecular Imaging. Curr. Opin. Chem. Biol. 2017, 39, 32– 38. 28544971
  41. [42]Okamoto S; Eltis LD The Biological Occurrence and Trafficking of Cobalt. Metallomics 2011, 3, 963– 970. 21804980
  42. [43]Mendel RR; Bittner F Cell Biology of Molybdenum. Biochim. Biophys. Acta, Mol. Cell Res. 2006, 1763, 621– 635. 16784786
  43. [44]Hille R; Hall J; Basu P The Mononuclear Molybdenum Enzymes. Chem. Rev. 2014, 114, 3963– 4038. 24467397 PMC4080432
  44. [45]Aihemaiti A; Jiang J; Gao Y; Meng Y; Zou Q; Yang M; Xu Y; Han S; Yan W; Tuerhong T The Effect of Vanadium on Essential Element Uptake of Setaria Viridis’ Seedlings. J. Environ. Manage. 2019, 237, 399– 407. 30818242
  45. [46]Harland BF; Harden-Williams BA Is Vanadium of Human Nutritional Importance Yet? J. Am. Diet Assoc. 1994, 94, 891– 894. 8046184
  46. [47]Rehder D Vanadium. Its Role for Humans. In: Sigel A, Sigel H, Sigel R.(eds) Interrelations between Essential Metal Ions and Human Diseases; Springer; 2013; pp 139. PMC7120733 24470091
  47. [48]Kaplan J; Ward DM The Essential Nature of Iron Usage and Regulation. Curr. Biol. 2013, 23, R642– R646. 23928078 PMC3928970
  48. [49]Sheftel AD; Mason AB; Ponka P The Long History of Iron in the Universe and in Health and Disease. Biochim. Biophy. Acta, Gen. Subj. 2012, 1820, 161– 187. PMC3258305 21856378
  49. [50]Strandberg B Chapter 1: Building the Ground for the First Two Protein Structures: Myoglobin and Haemoglobin. J. Mol. Biol. 2009, 392, 2– 10. 19712775
  50. [51]Cammack R; Wrigglesworth JM; Baum H Iron-Dependent Enzymes in Mammalian Systems. Iron Transport and Storage 1990 CRC Press, Boca Raton.
  51. [54]Andrews NC Iron Homeostasis: Insights from Genetics and Animal Models. Nat. Rev. Genet. 2000, 1, 208– 217. 11252750
  52. [55]Xu W; Barrientos T; Andrews NC Iron and Copper in Mitochondrial Diseases. Cell. Metab. 2013, 17, 319– 328. 23473029 PMC3594794
  53. [56]Ginzburg YZ; Finberg KE Iron Metabolism and Related Disorders. In Emery and Rimoin’s Principles and Practice of Medical Genetics and Genomics: Metabolic Disorders; Elsevier, Inc., 2021, 445– 499.
  54. [57]Dixon SJ; Lemberg KM; Lamprecht MR; Skouta R; Zaitsev EM; Gleason CE; Patel DN; Bauer AJ; Cantley AM; Yang WS; Ferroptosis: An Iron-Dependent Form of Nonapoptotic Cell Death. Cell 2012, 149, 1060– 1072. 22632970 PMC3367386
  55. [58]Lei G; Zhuang L; Gan B Targeting Ferroptosis as a Vulnerability in Cancer. Nat. Rev. Cancer 2022, 22, 381– 396. 35338310 PMC10243716
  56. [59]Reichert CO; de Freitas FA; Sampaio-Silva J; Rokita-Rosa L; Barros P.de L.; Levy D.; Bydlowski SP. Ferroptosis Mechanisms Involved in Neurodegenerative Diseases. Int. J. Mol. Sci. 2020, 21, 8765. 33233496 PMC7699575
  57. [60]Aron AT; Reeves AG; Chang CJ Activity-Based Sensing Fluorescent Probes for Iron in Biological Systems. Curr. Opin. Chem. Biol. 2018, 43, 113– 118. 29306820 PMC5847483
  58. [61]Varnes AW; Dodson RB; Wehry EL Interactions of Transition-Metal Ions with Photoexcited States of Flavins. Fluorescence Quenching Studies. J. Am. Chem. Soc. 1972, 94, 946– 950. 5061141
  59. [62]Irving H; Williams RJP 637. The Stability of Transition-Metal Complexes. J. Chem. Soc. 1953, 3245, 3192– 3210.
  60. [63]Breuer W; Epsztejn S; Cabantchik ZI Iron Acquired from Transferrin by K562 Cells Is Delivered into a Cytoplasmic Pool of Chelatable Iron(II). J. Biol. Chem. 1995, 270, 24209– 24215. 7592626
  61. [64]Breuer W; Epsztejn S; Millgram P; Cabantchik IZ Transport of Iron and Other Transition Metals into Cells as Revealed by a Fluorescent Probe. Am. J. Physiol. Cell Physiol. 1995, 268, C1354– C1361. 7611353
  62. [65]Petrat F; Rauen U; De Groot H Determination of the Chelatable Iron Pool of Isolated Rat Hepatocytes by Digital Fluorescence Microscopy Using the Fluorescent Probe, Phen Green SK. Hepatology 1999, 29, 1171– 1179. 10094962
  63. [66]Petrat F; Weisheit D; Lensen M; de Groot H; Sustmann R; Rauen U Selective Determination of Mitochondrial Chelatable Iron in Viable Cells with a New Fluorescent Sensor. Biochem. J. 2002, 362, 137– 147. 11829750 PMC1222370
  64. [67]Kholmukhamedov A; Li L; Lindsey CC; Hu J; Nieminen A-L; Takemoto K; Beeson GC; Beneker CM; McInnes C; Beeson CC; A New Fluorescent Sensor Mitoferrofluor Indicates the Presence of Chelatable Iron in Polarized and Depolarized Mitochondria. J. Biol. Chem. 2022, 298, 102336. 35931111 PMC9460511
  65. [68]Bhuvanesh N; Velmurugan K; Suresh S; Prakash P; John N; Murugan S; Daniel Thangadurai T; Nandhakumar R Naphthalene Based Fluorescent Chemosensor for Fe2+-Ion Detection in Microbes and Real Water Samples. J. Lumin. 2017, 188, 217– 222.
  66. [69]Hou GG; Wang CH; Sun JF; Yang MZ; Lin D; Li HJ Rhodamine-Based “Turn-on” Fluorescent Probe with High Selectivity for Fe2+ Imaging in Living Cells. Biochem. Biophys. Res. Commun. 2013, 439, 459– 463. 24025683
  67. [70]Li P; Fang L; Zhou H; Zhang W; Wang X; Li N; Zhong H; Tang B A New Ratiometric Fluorescent Probe for Detection of Fe2+ with High Sensitivity and Its Intracellular Imaging Applications. Chem. Eur. J. 2011, 17, 10520– 10523. 21850713
  68. [71]Carney IJ; Kolanowski JL; Lim Z; Chekroun B; Torrisi AG; Hambley TW; New EJ A Ratiometric Iron Probe Enables Investigation of Iron Distribution within Tumour Spheroids. Metallomics 2018, 10, 553– 556. 29658547
  69. [72]Hirayama T; Okuda K; Nagasawa H A Highly Selective Turn-on Fluorescent Probe for Iron(II) to Visualize Labile Iron in Living Cells. Chem. Sci. 2013, 4, 1250– 1256.
  70. [73]Niwa M; Hirayama T; Okuda K; Nagasawa H A New Class of High-Contrast Fe(I) Selective Fluorescent Probes Based on Spirocyclized Scaffolds for Visualization of Intracellular Labile Iron Delivered by Transferrin. Org. Biomol. Chem. 2014, 12, 6590– 6597. 24953684
  71. [74]Hirayama T; Niwa M; Hirosawa S; Nagasawa H High-Throughput Screening for the Discovery of Iron Homeostasis Modulators Using an Extremely Sensitive Fluorescent Probe. ACS Sens. 2020, 5, 2950– 2958. 32885952
  72. [75]Hirayama T; Tsuboi H; Niwa M; Miki A; Kadota S; Ikeshita Y; Okuda K; Nagasawa H A Universal Fluorogenic Switch for Fe(II) Ion Based on N-Oxide Chemistry Permits the Visualization of Intracellular Redox Equilibrium Shift towards Labile Iron in Hypoxic Tumor Cells. Chem. Sci. 2017, 8, 4858– 4866. 28959409 PMC5603896
  73. [76]Niwa M; Hirayama T; Oomoto I; Wang DO; Nagasawa H Fe(II) Ion Release during Endocytotic Uptake of Iron Visualized by a Membrane-Anchoring Fe(II) Fluorescent Probe. ACS Chem. Biol. 2018, 13, 1853– 1861. 29297678
  74. [77]Hirayama T; Kadota S; Niwa M; Nagasawa H A Mitochondria-Targeted Fluorescent Probe for Selective Detection of Mitochondrial Labile Fe(II). Metallomics 2018, 10, 794– 801. 29863204
  75. [78]Khatun S; Biswas S; Binoy A; Podder A; Mishra N; Bhuniya S Highly Chemoselective Turn-on Fluorescent Probe for Ferrous (Fe2+) Ion Detection in Cosmetics and Live Cells. J. Photochem. Photobiol. B 2020, 209, 111943. 32615489
  76. [79]Hirayama T; Inden M; Tsuboi H; Niwa M; Uchida Y; Naka Y; Hozumi I; Nagasawa H A Golgi-Targeting Fluorescent Probe for Labile Fe(II) to Reveal an Abnormal Cellular Iron Distribution Induced by Dysfunction of VPS35. Chem. Sci. 2019, 10, 1514– 1521. 30809369 PMC6357701
  77. [80]Yang X; Wang Y; Liu R; Zhang Y; Tang J; Yang E.bing; Zhang D; Zhao Y; Ye Y. A Novel ICT-Based Two Photon and NIR Fluorescent Probe for Labile Fe2+ Detection and Cell Imaging in Living Cells. Sens. Actuators B Chem. 2019, 288, 217– 224.
  78. [81]Zheng J; Feng S; Gong S; Xia Q; Feng G In Vivo Imaging of Fe2+ Using an Easily Obtained Probe with a Large Stokes Shift and Bright Strong Lipid Droplet-Targetable near-Infrared Fluorescence. Sens. Actuators B Chem. 2020, 309, 127796.
  79. [82]Yang L; Chen Q; Gan S; Guo Q; Zhang J; Zhang H; Xie Y; Xiao H; Wang W; Sun H An Activatable AIEgen Probe for In-Situ Monitoring and Long-Term Tracking of Ferrous Ions in Living Cells. Dyes Pigm. 2021, 190, 109271.
  80. [83]Zhu M; Zhao Z; Liu X; Chen P; Fan F; Wu X; Hua R; Wang Y A Novel Near-Infrared Fluorimetric Method for Point-of-Care Monitoring of Fe2+ and Its Application in Bioimaging. J. Hazard Mater. 2021, 406, 124767. 33310335
  81. [84]Feng S; Zheng J; Zhang J; Gui Z; Feng G Fe2+ Imaging in Ferroptosis and Drug-Induced Liver Injury with a Ratiometric near-Infrared Fluorescent Probe. Sens. Actuators B Chem. 2022, 371, 132512.
  82. [85]Huang L; Chen Y; Zhao Y; Wang Y; Xiong J; Zhang J; Wu X; Zhou Y A Ratiometric Near-Infrared Naphthalimide-Based Fluorescent Probe with High Sensitivity for Detecting Fe2+ in Vivo. Chin. Chem. Lett. 2020, 31, 2941– 2944.
  83. [86]Gao G; Wang X; Wang Z; Jin X; Ou L; Zhou J; Xie P A Simple and Effective Dansyl Acid Based “Turn-on” Fluorescent Probe for Detecting Labile Ferrous Iron in Physiological Saline and Live Cells. Talanta 2020, 215, 120908. 32312452
  84. [87]Dong B; Song W; Lu Y; Tian M; Kong X; Mehmood AH; Lin W Live Cell-Specific Fluorescent Probe for the Detection of Labile Fe(II) and the Evaluation of Esterase Activity in Live Animals. Sens. Actuators B Chem. 2020, 305, 127470.
  85. [88]Zhang Y; Gong S; Song J; Li M; Qin A; Gao Y; Wang Z; Wang S A Robust Camphor-Based Colorimetric and Fluormetric Dual-Modal Probe with a Large Stokes Shift for Real-Time Monitoring of Endogenous Labile Fe2+ in Vivo and in Vitro. Dyes Pigm. 2021, 194, 109590.
  86. [89]Liang Y; Zhang Y; Li M; Meng Z; Gao Y; Yin J; Yang Y; Wang Z; Wang S A Highly Effective “Turn-on” Camphor-Based Fluorescent Probe for Rapid and Sensitive Detection and Its Biological Imaging of Fe2+. Anal. Bioanal. Chem. 2021, 413, 6267– 6277. 34355255
  87. [90]Zeng X; Chen J; Yu S; Liu Z; Ma M A Highly Selective and Sensitive “Turn-on” Fluorescent Probe for Fe2+ and Its Applications. J. Lumin. 2022, 250, 119069.
  88. [91]Knox HJ; Hedhli J; Kim TW; Khalili K; Dobrucki LW; Chan J A Bioreducible N-Oxide-Based Probe for Photoacoustic Imaging of Hypoxia. Nat. Commun. 2017, 8, 1– 9. 29176550 PMC5702603
  89. [92]Knox HJ; Kim TW; Zhu Z; Chan J Photophysical Tuning of N-Oxide-Based Probes Enables Ratiometric Photoacoustic Imaging of Tumor Hypoxia. ACS Chem. Biol. 2018, 13, 1838– 1843. 29521492
  90. [93]Ross MF; Kelso GF; Blaikie FH; James AM; Cochemé HM; Filipovska A; Da Ros T; Hurd TR; Smith RAJ; Murphy MP Lipophilic Triphenylphosphonium Cations as Tools in Mitochondrial Bioenergetics and Free Radical Biology. Biochemistry (Moscow) 2005, 70, 222– 230. 15807662
  91. [94]Hirayama T; Miki A; Nagasawa H Organelle-Specific Analysis of Labile Fe(II) during Ferroptosis by Using a Cocktail of Various Colour Organelle-Targeted Fluorescent Probes. Metallomics 2019, 11, 111– 117. 30215439
  92. [95]Ishida M; Watanabe H; Takigawa K; Kurishita Y; Oki C; Nakamura A; Hamachi I; Tsukiji S Synthetic Self-Localizing Ligands That Control the Spatial Location of Proteins in Living Cells. J. Am. Chem. Soc. 2013, 135, 12684– 12689. 23941503
  93. [96]Au-Yeung HY; Chan J; Chantarojsiri T; Chang CJ Molecular Imaging of Labile Iron(II) Pools in Living Cells with a Turn-on Fluorescent Probe. J. Am. Chem. Soc. 2013, 135, 15165– 15173. 24063668 PMC3838104
  94. [97]Feng P; Ma L; Xu F; Gou X; Du L; Ke B; Li M In Vivo Bioluminescence Imaging of Labile Iron Pools in a Murine Model of Sepsis with a Highly Selective Probe. Talanta 2019, 203, 29– 33. 31202341
  95. [98]Wu L; Ding Q; Wang X; Li P; Fan N; Zhou Y; Tong L; Zhang W; Zhang W; Tang B Visualization of Dynamic Changes in Labile Iron(II) Pools in Endoplasmic Reticulum Stress-Mediated Drug-Induced Liver Injury. Anal. Chem. 2020, 92, 1245– 1251. 31820623
  96. [99]Spangler B; Morgan CW; Fontaine SD; Wal MNV; Chang CJ; Wells JA; Renslo AR A Reactivity-Based Probe of the Intracellular Labile Ferrous Iron Pool. Nat. Chem. Biol. 2016, 12, 680– 685. 27376690 PMC4990480
  97. [100]Aron AT; Loehr MO; Bogena J; Chang CJ An Endoperoxide Reactivity-Based FRET Probe for Ratiometric Fluorescence Imaging of Labile Iron Pools in Living Cells. J. Am. Chem. Soc. 2016, 138, 14338– 14346. 27768321 PMC5749882
  98. [101]Maiti S; Aydin Z; Zhang Y; Guo M Reaction-Based Turn-on Fluorescent Probes with Magnetic Responses for Fe2+ Detection in Live Cells. Dalton Trans. 2015, 44, 8942– 8949. 25875289
  99. [102]Zhang X; Chen Y; Cai X; Liu C; Jia P; Li Z; Zhu H; Yu Y; Wang K; Li X; A Highly Sensitive Rapid-Response Fluorescent Probe for Specifically Tracking Endogenous Labile Fe2+ in Living Cells and Zebrafish. Dyes Pigm. 2020, 174, 108065.
  100. [103]Xuan W; Pan R; Wei Y; Cao Y; Li H; Liang F.Sen; Liu KJ.; Wang W. Reaction-Based “Off-On” Fluorescent Probe Enabling Detection of Endogenous Labile Fe2+ and Imaging of Zn2+-Induced Fe2+ Flux in Living Cells and Elevated Fe2+ in Ischemic Stroke. Bioconjug. Chem. 2016, 27, 302– 308. 26284503
  101. [104]Xing W; Xu H; Ma H; Abedi SAA; Wang S; Zhang X; Liu X; Xu H; Wang W; Lou K A PET-Based Fluorescent Probe for Monitoring Labile Fe(II) Pools in Macrophage Activations and Ferroptosis. Chem. Commun. 2022, 58, 2979– 2982. 35147150
  102. [105]Qu Z; Li P; Zhang X; Han K A Turn-on Fluorescent Chemodosimeter Based on Detelluration for Detecting Ferrous Iron (Fe2+) in Living Cells. J. Mater. Chem. B 2016, 4, 887– 892. 32263161
  103. [106]Long L; Wang N; Han Y; Huang M; Yuan X; Cao S; Gong A; Wang K A Coumarin-Based Fluorescent Probe for Monitoring Labile Ferrous Iron in Living Systems. Analyst 2018, 143, 2555– 2562. 29721571
  104. [107]Cai CH; Wang HL; Man RJ Monitoring of Fe (II) Ions in Living Cells Using a Novel Quinoline-Derived Fluorescent Probe. Spectrochim. Acta A Mol. Biomol. Spectrosc. 2021, 255, 119729. 33784593
  105. [108]Protchenko O; Baratz E; Jadhav S; Li F; Shakoury-Elizeh M; Gavrilova O; Ghosh MC; Cox JE; Maschek JA; Tyurin VA; Iron Chaperone Poly RC Binding Protein 1 Protects Mouse Liver from Lipid Peroxidation and Steatosis. Hepatology 2021, 73, 1176– 1193. 32438524 PMC8364740
  106. [109]Matthieu A; Alejandro C; Juan W; P SC; T AA; J CC; Frances; Arash. Magnetotactic Bacteria Accumulate a Large Pool of Iron Distinct from Their Magnetite Crystals. Appl. Environ. Microbiol. 2020, 86, e01278– 20. 32887716 PMC7642088
  107. [110]Venkatesh D; O’Brien NA; Zandkarimi F; Tong DR; Stokes ME; Dunn DE; Kengmana ES; Aron AT; Klein AM; Csuka JM; MDM2 and MDMX Promote Ferroptosis by PPARα-Mediated Lipid Remodeling. Genes Dev. 2020, 34, 526– 543. 32079652 PMC7111265
  108. [111]Camarena V; Sant DW; Huff TC; Mustafi S; Muir RK; Aron AT; Chang CJ; Renslo AR; Monje PV; Wang G CAMP Signaling Regulates DNA Hydroxymethylation by Augmenting the Intracellular Labile Ferrous Iron Pool. Elife 2017, 6, e29750. 29239726 PMC5745079
  109. [112]Huff TC; Camarena V; Sant DW; Wilkes Z; Booven D.Van; Aron AT; Muir RK; Renslo AR; Chang CJ; Monje PV; Oscillatory CAMP Signaling Rapidly Alters H3K4 Methylation. Life Sci. Alliance 2020, 3, e201900529. 31882444 PMC6935296
  110. [113]Spangler B; Morgan CW; Fontaine SD; Wal MNV; Chang CJ; Wells JA; Renslo AR A Reactivity-Based Probe of the Intracellular Labile Ferrous Iron Pool. Nat. Chem. Biol. 2016, 12, 680– 685. 27376690 PMC4990480
  111. [114]Chen YC; Oses-Prieto JA; Pope LE; Burlingame AL; Dixon SJ; Renslo AR Reactivity-Based Probe of the Iron(II)-Dependent Interactome Identifies New Cellular Modulators of Ferroptosis. J. Am. Chem. Soc. 2020, 142, 19085– 19093. 33124817 PMC8297516
  112. [115]Gaschler MM; Andia AA; Liu H; Csuka JM; Hurlocker B; Vaiana CA; Heindel DW; Zuckerman DS; Bos PH; Reznik E; FINO2 Initiates Ferroptosis Through GPX4 Inactivation and Iron Oxidation. Nat. Chem. Biol. 2018, 14, 507. 29610484 PMC5899674
  113. [116]Aron AT; Heffern MC; Lonergan ZR; Vander Wal MN; Blank BR; Spangler B; Zhang Y; Park HM; Stahl A; Renslo AR; In Vivo Bioluminescence Imaging of Labile Iron Accumulation in a Murine Model of Acinetobacter Baumannii Infection. Proc. Natl. Acad. Sci. USA 2017, 114, 12669– 12674. 29138321 PMC5715752
  114. [117]Gonciarz RL; Jiang H; Tram L; Hugelshofer CL; Ekpenyong O; Knemeyer I; Aron AT; Chang CJ; Flygare JA; Collisson EA; In Vivo Bioluminescence Imaging of Labile Iron in Xenograft Models and Liver Using FeAL-1, an Iron-Activatable Form of D-Luciferin. Cell Chem. Biol. 2023, 30, 1468– 1477. 37820725 PMC10841594
  115. [118]Yanatori I; Nishina S; Kishi F; Hino K Newly Uncovered Biochemical and Functional Aspects of Ferritin. The FASEB J. 2023, 37, e23095. 37440196
  116. [119]Albelda-Berenguer M; Monachon M; Joseph E Siderophores: From Natural Roles to Potential Applications. Adv. Appl. Microbiol. 2019, 106, 193– 225. 30798803
  117. [120]Ma Y; de Groot H; Liu Z; Hider RC; Petrat F Chelation and Determination of Labile Iron in Primary Hepatocytes by Pyridinone Fluorescent Probes. Biochem. J. 2006, 395, 49– 55. 16336208 PMC1409684
  118. [121]Ma Y; Liu Z; Hider RC; Petrat F Determination of the Labile Iron Pool of Human Lymphocytes Using the Fluorescent Probe, CP655. Anal. Chem. Insights 2007, 2, 61– 67. 19662178 PMC2716813
  119. [122]Fakih S; Podinovskaia M; Kong X; Schaible UE; Collins HL; Hider RC Monitoring Intracellular Labile Iron Pools: A Novel Fluorescent Iron(III) Sensor as a Potential Non-Invasive Diagnosis Tool. J. Pharm. Sci. 2009, 98, 2212– 2226. 18823046
  120. [123]Qu X; Liu Q; Ji X; Chen H; Zhou Z; Shen Z Enhancing the Stokes’ Shift of BODIPY Dyes via through-Bond Energy Transfer and Its Application for Fe3+-Detection in Live Cell Imaging. Chem. Commun. 2012, 48, 4600– 4602. 22466507
  121. [124]Wang W; Wu J; Liu Q; Gao Y; Liu H; Zhao B A Highly Selective Coumarin-Based Chemosensor for the Sequential Detection of Fe3+ and Pyrophosphate and Its Application in Living Cell Imaging. Tetrahedron Lett. 2018, 59, 1860– 1865.
  122. [125]Meghdadi S; Khodaverdian N; Amirnasr A; French PJ; van Royen ME; Wiemer EAC; Amirnasr M A New Carboxamide Probe as On-Off Fluorescent and Colorimetric Sensor for Fe3+ and Application in Detecting Intracellular Fe3+ Ion in Living Cells. J. Photochem. Photobiol. A Chem. 2020, 389, 112193.
  123. [126]Tehrani T; Meghdadi S; Salarvand Z; Tavakoli B; Eskandari K; Amirnasr M An Anthracene-Quinoline Based Dual-Mode Fluorometric-Colorimetric Sensor for the Detection of Fe3+and Its Application in Live Cell Imaging. New J. Chem. 2021, 45, 8109– 8117.
  124. [127]Musikavanhu B; Zhu D; Tang M; Xue Z; Wang S; Zhao L A Naphthol Hydrazone Schiff Base Bearing Benzothiadiazole Unit for Fluorescent Detection of Fe3+ in PC3 Cells. Spectrochim. Acta A Mol. Biomol. Spectrosc. 2023, 289, 122242. 36542920
  125. [128]Yu F; Qin L; Shang Z; Dong Z; Wang Y; Jin W Azomethine-H as a Highly Selective Fluorescent Probe for Fe3+ Detection in 100% Aqueous Solution and Its Application in Living Cell Imaging. Chem. Res. Chin. Univ. 2015, 31, 919– 924.
  126. [129]Maity P; Naskar B; Goswami S; Prodhan C; Chaudhuri T; Chaudhuri K; Mukhopadhyay C Pyrrolo[3,4- c]Pyridine-Based Fluorescent Chemosensor for Fe3+/Fe2+ Sensitivity and Their Application in Living HepG2 Cells. ACS Omega 2018, 3, 18646– 18655.
  127. [130]Selvaraj M; Rajalakshmi K; Nam YS; Lee Y; Song JW; Lee HJ; Lee KB On-off-on Relay Fluorescence Recognition of Ferric and Fluoride Ions Based on Indicator Displacement in Living Cells. Anal. Chim. Acta 2019, 1066, 112– 120. 31027525
  128. [131]Geng Y; Chen L; Wan Q; Lian C; Han Y; Wang Y; Zhang C; Huang L; Zhao H; Sun X; A Novel [1,2,4]Triazolo[1,5-a]Pyrimidine Derivative as a Fluorescence Probe for Specific Detection of Fe3+ Ions and Application in Cell Imaging. Anal. Chim. Acta 2021, 1187, 339168. 34753578
  129. [132]Jamuna K; Thimmarayaperumal S; Aravind MK; Sivakumar S; Ashokkumar B Synthesis of Indenophenanthridine via a [4+2] Annulation Strategy: A “turn-off” Fe3+ Ion Sensor, Practical Application in Live Cell Imaging and Reversible Acidochromism Studies. New J. Chem. 2022, 46, 9207– 9213.
  130. [133]Yang X; Chen X; Lu X; Yan C; Xu Y; Hang X; Qu J; Liu R A Highly Selective and Sensitive Fluorescent Chemosensor for Detection of CN-, SO32- and Fe3+ Based on Aggregation-Induced Emission. J. Mater. Chem. C Mater. 2016, 4, 383– 390.
  131. [134]He Y; Sun X; Yan X; Li Y; Zhong K; Tang L A Colorimetric, NIR, Ultrafast Fluorescent Probe for Ferric Iron Detection Based on the PET Mechanism and Its Multiple Applications. J. Mater. Chem. C Mater. 2022, 10, 9009– 9016.
  132. [135]Zhang YP; Teng Q; Yang YS; Guo HC; Xue JJ A Novel Coumarin-Based Pyrazoline Fluorescent Probe for Detection of Fe3+ and Its Application in Cells. Inorganica Chim. Acta 2021, 525, 120469.
  133. [136]Hoyes KP; Porter JB Subcellular Distribution of Desferrioxamine and Hydroxypyridin-4-One Chelators in K562 Cells Affects Chelation of Intracellular Iron Pools. Br. J. Haematol. 1993, 85, 393– 400. 8280612
  134. [137]Nandre J; Patil S; Patil V; Yu F; Chen L; Sahoo S; Prior T; Redshaw C; Mahulikar P; Patil U A Novel Fluorescent “Turn-on” Chemosensor for Nanomolar Detection of Fe(III) from Aqueous Solution and Its Application in Living Cells Imaging. Biosens. Bioelectron. 2014, 61, 612– 617. 24967750
  135. [138]Qiu L; Zhu C; Chen H; Hu M; He W; Guo Z A Turn-on Fluorescent Fe3+ Sensor Derived from an Anthracene-Bearing Bisdiene Macrocycle and Its Intracellular Imaging Application. Chem. Commun. 2014, 50, 4631– 4634. 24668051
  136. [139]Sui B; Tang S; Liu T; Kim B; Belfield KD Novel BODIPY-Based Fluorescence Turn-on Sensor for Fe3+ and Its Bioimaging Application in Living Cells. ACS Appl. Mater. Interfaces 2014, 6, 18408– 18412. 25337695
  137. [140]Rasin P; Manakkadan V; Vadakkedathu Palakkeezhillam VN; Haribabu J; Echeverria C; Sreekanth A Simple Fluorescence Sensing Approach for Selective Detection of Fe3+ Ions: Live-Cell Imaging and Logic Gate Functioning. ACS Omega 2022, 7, 33248– 33257. 36157778 PMC9494683
  138. [141]Zhang M; Gao Y; Li M; Yu M; Li F; Li L; Zhu M; Zhang J; Yi T; Huang C A Selective Turn-on Fluorescent Sensor for Fe(III) and Application to Bioimaging. Tetrahedron Lett. 2007, 48, 3709– 3712.
  139. [142]Gao Y; Liu H; Liu Q; Wang W A Novel Colorimetric and OFF-ON Fluorescent Chemosensor Based on Fluorescein Derivative for the Detection of Fe3+ in Aqueous Solution and Living Cells. Tetrahedron Lett. 2016, 57, 1852– 1855.
  140. [143]Wang Q; Zheng D; Cao Q; Huang K; Qin D A Dual-Response Fluoran-Phenothiazine Hybrid Fluorescent Probe for Selective Sensing of Fe3+ and ClO− and Cell Imaging Application. Spectrochim. Acta A Mol. Biomol. Spectrosc. 2021, 261, 120061. 34146825
  141. [144]Chung PK; Liu SR; Wang HF; Wu SP A Pyrene-Based Highly Selective Turn-on Fluorescent Chemosensor for Iron(III) Ions and Its Application in Living Cell Imaging. J. Fluoresc. 2013, 23, 1139– 1145. 23821065
  142. [145]Nandhini T; Kaleeswaran P; Pitchumani K A Highly Selective, Sensitive and “Turn-on” Fluorescent Sensor for the Paramagnetic Fe3+ Ion. Sens. Actuators B Chem. 2016, 230, 199– 205.
  143. [146]Lee JS; Warkad SD; Shinde PB; Kuwar A; Nimse SB A Highly Selective Fluorescent Probe for Nanomolar Detection of Ferric Ions in the Living Cells and Aqueous Media. Arab. J. Chem. 2020, 13, 8697– 8707.
  144. [147]Nootem J; Sattayanon C; Daengngern R; Kamkaew A; Wattanathana W; Wannapaiboon S; Rashatasakhon P; Chansaenpak K Bodipy-Pyridylhydrazone Probe for Fluorescence Turn-on Detection of Fe3+ and Its Bioimaging Application. Chemosensors 2021, 9, 165.
  145. [148]Feng X; Li Y; He X; Liu H; Zhao Z; Kwok RTK; Elsegood MRJ; Lam JWY; Tang BZ A Substitution-Dependent Light-Up Fluorescence Probe for Selectively Detecting Fe3+ Ions and Its Cell Imaging Application. Adv. Funct. Mater. 2018, 28, 1802833.
  146. [149]Goel A; Umar S; Nag P; Sharma A; Kumar L; Shamsuzzama; Hossain Z; Gayen JR; Nazir A. A Dual Colorimetric-Ratiometric Fluorescent Probe NAP-3 for Selective Detection and Imaging of Endogenous Labile Iron(III) Pools in C. Elegans. Chem. Commun. 2015, 51, 5001– 5004. 25633904
  147. [150]Bordini J; Calandreli I; Silva GO; Ferreira KQ; Leitão-Mazzi DPS; Espreafico EM; Tfouni E A Rhodamine-B-Based Turn-on Fluorescent Sensor for Biological Iron(III). Inorg. Chem. Commun. 2013, 35, 255– 259.
  148. [151]Fan C; Huang X; Han L; Lu Z; Wang Z; Yi Y Novel Colorimetric and Fluorescent Off-on Enantiomers with High Selectivity for Fe3+ Imaging in Living Cells. Sens. Actuators B Chem. 2015, 224, 592– 599.
  149. [152]Adhikari S; Ghosh A; Ghosh M; Guria S; Das D Ratiometric Sensing of Fe3+ through PET-CHEF-FRET Processes: Live Cell Imaging, Speciation and DFT Studies. Sens. Actuators B Chem. 2017, 251, 942– 950.
  150. [153]Cao X; Zhang F; Bai Y; Ding X; Sun W A Highly Selective “Turn-on” Fluorescent Probe for Detection of Fe 3+ in Cells. J. Fluoresc. 2019, 29, 425– 434. 30725356
  151. [154]Shellaiah M; Thirumalaivasan N; Aazaad B; Awasthi K; Sun KW; Wu SP; Lin MC; Ohta N Novel Rhodamine Probe for Colorimetric and Fluorescent Detection of Fe3+ Ions in Aqueous Media with Cellular Imaging. Spectrochim. Acta A Mol. Biomol. Spectrosc. 2020, 242, 118757. 32791389
  152. [155]Alhawsah B; Yan B; Aydin Z; Niu X; Guo M Highly Selective Fluorescent Probe With an Ideal PH Profile for the Rapid and Unambiguous Determination of Subcellular Labile Iron (III) Pools in Human Cells. Anal. Lett. 2022, 55, 1954– 1970. 36310627 PMC9611270
  153. [156]Bao X; Shi J; Nie X; Zhou B; Wang X; Zhang L; Liao H; Pang T A New Rhodamine B-Based “on-off” Chemical Sensor with High Selectivity and Sensitivity toward Fe3+ and Its Imaging in Living Cells. Bioorg. Med. Chem. 2014, 22, 4826– 4835. 25065941
  154. [157]Yan F; Zheng T; Shi D; Zou Y; Wang Y; Fu M; Chen L; Fu W Rhodamine-Aminopyridine Based Fluorescent Sensors for Fe3+ in Water: Synthesis, Quantum Chemical Interpretation and Living Cell Application. Sens. Actuators B Chem. 2015, 215, 598– 606.
  155. [158]Hu Y; Zhao F; Hu S; Dong Y; Li D; Su Z A Novel Turn-on Colorimetric and Fluorescent Sensor for Fe3+ and Its Application in Living Cells. J. Photochem. Photobiol. A Chem. 2017, 332, 351– 356.
  156. [159]Jin X; Wang S; Yin W; Xu T; Jiang Y; Liao Q; Xia X; Liu J A Highly Sensitive and Selective Fluorescence Chemosensor for Fe3+ Based on Rhodamine and Its Application in Vivo Imaging. Sens. Actuators B Chem. 2017, 247, 461– 468.
  157. [160]Wu Z.ying; Xu Z. yong; Yan J. wu; Li Y.; Kou Q.; Zhang L Development of Rhodamine-Based Fluorescent Probes for Sensitive Detection of Fe3+ in Water: Spectroscopic and Computational Investigations. New J. Chem. 2019, 43, 1725– 1732.
  158. [161]Bao X; Cao X; Nie X; Xu Y; Guo W; Zhou B; Zhang L; Liao H; Pang T A New Selective Fluorescent Chemical Sensor for Fe3+ Based on Rhodamine B and a 1,4,7,10-Tetraoxa-13-Azacyclopentadecane Conjugate and Its Imaging in Living Cells. Sens. Actuators B Chem. 2015, 208, 54– 66.
  159. [162]Wang Y; Song F; Zhu J; Zhang Y; Du L; Kan C Highly Selective Fluorescent Probe Based on a Rhodamine B and Furan-2-Carbonyl Chloride Conjugate for Detection of Fe3+ in Cells. Tetrahedron Lett. 2018, 59, 3756– 3762.
  160. [163]Wang KP; Zheng WJ; Lei Y; Zhang SJ; Zhang Q; Chen S; Hu ZQ A Thiophene-Rhodamine Dyad as Fluorescence Probe for Ferric Ion and Its Application in Living Cells Imaging. J. Lumin. 2019, 208, 468– 474.
  161. [164]Song F; Yang C; Liu H; Gao Z; Zhu J; Bao X; Kan C Dual-Binding Pyridine and Rhodamine B Conjugate Derivatives as Fluorescent Chemosensors for Ferric Ions in Aqueous Media and Living Cells. Analyst 2019, 144, 3094– 3102. 30920566
  162. [165]Ghosh A; Mandal S; Das S; Shaw P; Chattopadhyay A; Sahoo P Insights into the Phenomenon of Acquisition and Accumulation of Fe3+ in Hygrophila Spinosa through Fluorimetry and Fluorescence Images. Tetrahedron Lett. 2020, 61, 151520.
  163. [166]Kan C; Song F; Shao X; Wu L; Zhang X; Zhang Y; Zhu J Imaging of Living Organisms and Determination of Real Water Samples Using a Rhodamine-Based Fe(III)-Induced Fluorescent Probe. Microchem. J. 2020, 154, 104587.
  164. [167]Zhang J; Bai CB; Chen MY; Yue SY; Qin YX; Liu XY; Xu MY; Zheng QJ; Zhang L; Li RQ; Novel Fluorescent Probe toward Fe3+Based on Rhodamine 6G Derivatives and Its Bioimaging in Adult Mice, Caenorhabditis Elegans, and Plant Tissues. ACS Omega 2021, 6, 8616– 8624. 33817522 PMC8015108
  165. [168]Luo A; Wang H; Wang Y; Huang Q; Zhang Q A Novel Colorimetric and Turn-on Fluorescent Chemosensor for Iron(III) Ion Detection and Its Application to Cellular Imaging. Spectrochim. Acta A Mol. Biomol. Spectrosc. 2016, 168, 37– 44. 27267282
  166. [169]Liu P; Luo A; Wang Y; Hu J; Huang Q; Wang H A Bis-(Rhodamine)-Based off–on Colorimetric and Fluorescent Probe for Fe3+ Ion Detection in Serum and Bioimaging. Chem. Pap. 2018, 72, 2575– 2587.
  167. [170]Gao Z; Kan C; Liu H; Zhu J; Bao X A Highly Sensitive and Selective Fluorescent Probe for Fe3+ Containing Two Rhodamine B and Thiocarbonyl Moieties and Its Application to Live Cell Imaging. Tetrahedron 2019, 75, 1223– 1230.
  168. [171]Qian Y; Suo J; Gao Z; Liu H; Hua Q; Lu Y; Zhang P; Kan C; Bao X; Zhu J A Selective and Sensitive Turn-on Chemosensor for Detection of Fe3+ in Aqueous Solution and Its Cell Imaging in Dorsal Root Ganglia Neurons and MKN-45 Cells. Bioorg. Med. Chem. 2020, 28, 115309. 31956053
  169. [172]Song F; Shao X; Zhu J; Bao X; Du L; Kan C Reversible “Turn-off-on” Fluorescence Response of Fe(III) towards Rhodamine B Based Probe in Vivo and Plant Tissues. Tetrahedron Lett. 2019, 60, 1363– 1369.
  170. [173]Kan C; Song F; Shao X; Wu L; Zhu J Fe(III) Induced Fluorescent Probe Based on Triamine and Rhodamine Derivatives and Its Applications in Biological Imaging. J. Photochem. Photobiol. A Chem. 2020, 390, 112306.
  171. [174]Gao J; He Y; Chen Y; Song D; Zhang Y; Qi F; Guo Z; He W Reversible FRET Fluorescent Probe for Ratiometric Tracking of Endogenous Fe3+in Ferroptosis. Inorg. Chem. 2020, 59, 10920– 10927. 32654480
  172. [175]Molla HA; Bhowmick R; Katarkar A; Chaudhuri K; Gangopadhyay S; Ali M A Novel Rhodamine-3,4-Dihydro-2H-1,3-Benzoxazine Conjugate as a Highly Sensitive and Selective Chemosensor for Fe3+ Ions with Cytoplasmic Cell Imaging Possibilities. Anal. Methods 2015, 7, 5149– 5156.
  173. [176]Zhang M; Shen C; Jia T; Qiu J; Zhu H; Gao Y One-Step Synthesis of Rhodamine-Based Fe3+ Fluorescent Probes via Mannich Reaction and Its Application in Living Cell Imaging. Spectrochim. Acta A Mol. Biomol. Spectrosc. 2020, 231, 118105. 32006914
  174. [177]Zhu C; Wang M; Qiu L; Hao S; Li K; Guo Z; He W A Mitochondria-Targeting Fluorescent Fe3+ Probe and Its Application in Labile Fe3+ Monitoring via Imaging and Flow Cytometry. Dyes Pigm. 2018, 157, 328– 333.
  175. [178]Ma S; Yang Z; She M; Sun W; Yin B; Liu P; Zhang S; Li J Design and Synthesis of Functionalized Rhodamine Based Probes for Specific Intracellular Fluorescence Imaging of Fe3+. Dyes Pigm. 2015, 115, 120– 126.
  176. [179]Yang Z; Bai X; Ma S; Liu X; Zhao S; Yang Z A Benzoxazole Functionalized Fluorescent Probe for Selective Fe3+ Detection and Intracellular Imaging in Living Cells. Anal. Methods 2017, 9, 18– 22.
  177. [180]Cheng Z; Zheng L; Xu H; Pang L; He H A Rhodamine-Based Fluorescent Probe for Fe3+: Synthesis, Theoretical Calculation and Bioimaging Application. Anal. Methods 2019, 11, 2565– 2570.
  178. [181]Cheng Z; Liu X; Zheng L; Xu Y; He H Analyses on Intracellular Fe3+ with a Rhodamine Probe: “Turn-on” Response, Specific Recognition and Bioimaging. Anal. Methods 2022, 14, 2277– 2283. 35621919
  179. [182]Wang X; Huang J; Wei H; Wu L; Xing H; Zhu J; Kan C A Novel Fe3+ Fluorescent Probe Based on Rhodamine Derivatives and Its Application in Biological Imaging. J. Mol. Struct. 2022, 1270, 133979.
  180. [183]Kumar A; Kumari C; Sain D; Hira SK; Manna PP; Dey S Synthesis of Rhodamine-Based Chemosensor for Fe3+ Selective Detection with off–on Mechanism and Its Biological Application in DL-Tumor Cells. ChemistrySelect 2017, 2, 2969– 2974.
  181. [184]Zhou F; Leng TH; Liu YJ; Wang CY; Shi P; Zhu WH Water-Soluble Rhodamine-Based Chemosensor for Fe3+ with High Sensitivity, Selectivity and Anti-Interference Capacity and Its Imaging Application in Living Cells. Dyes Pigm. 2017, 142, 429– 436.
  182. [185]Ozdemir M; Zhang Y; Guo M A Highly Selective “off-on” Fluorescent Sensor for Subcellular Visualization of Labile Iron(III) in Living Cells. Inorg. Chem. Commun. 2018, 90, 73– 77.
  183. [186]Vijay N; Wu SP; Velmathi S Turn on Fluorescent Chemosensor Containing Rhodamine B Fluorophore for Selective Sensing and in Vivo Fluorescent Imaging of Fe3+ Ions in HeLa Cell Line and Zebrafish. J. Photochem. Photobiol. A Chem. 2019, 384, 112060.
  184. [187]Yang Y; Guo Z; Ye J; Gao CY; Liu J; Duan L Sulfonate Substituted Rhodamine Hydrophilic Fluorescent Probes: Application to Specific Detection of Fe3+ and Imaging in Living Fish. Spectrochim. Acta A Mol. Biomol. Spectrosc. 2021, 248, 119238. 33307348
  185. [188]Aribuga H; Ertugral U; Alcay Y; Yavuz O; Yildirim MS; Ozdemir E; Kaya K; Sert ABO; Kok FN; Tuzun NŞ; A New Fe3+-Selective, Sensitive, and Dual-Channel Turn-on Probe Based on Rhodamine Carrying Thiophenecarboxaldehyde: Smartphone Application and Imaging in Living Cells. Spectrochim. Acta A Mol. Biomol. Spectrosc. 2023, 287, 122060. 36395583
  186. [189]Sharma N; Reja SI; Gupta N; Bhalla V; Kaur D; Arora S; Kumar M A Highly Selective Fluorescent Probe for Fe3+ in Living Cells: A Stress Induced Cell Based Model Study. Org. Biomol. Chem. 2017, 15, 1006– 1012. 28074954
  187. [190]Liu XJ; Zhang M; Yang MP; Li B; Cheng Z; Yang BQ Low Cytotoxicity Rhodamine-Based Fluorescent Probes for Fe(III) and Their Application in Living Cells. Tetrahedron 2015, 71, 8194– 8199.
  188. [191]Sivaraman G; Sathiyaraja V; Chellappa D Turn-on Fluorogenic and Chromogenic Detection of Fe(III) and Its Application in Living Cell Imaging. J. Lumin. 2014, 145, 480– 485.
  189. [192]Liu Y; Shen R; Ru J; Yao X; Yang Y; Liu H; Tang X; Bai D; Zhang G; Liu W A Reversible Rhodamine 6G-Based Fluorescence Turn-on Probe for Fe3+ in Water and Its Application in Living Cell Imaging. RSC Adv. 2016, 6, 111754– 111759.
  190. [193]Vishaka VH; Saxena M; Geetha BR; Latiyan S; Jain S Remarkably Selective Biocompatible Turn-on Fluorescent Probe for Detection of Fe3+ in Human Blood Samples and Cells. RSC Adv. 2019, 9, 27439– 27448. 35529189 PMC9070666
  191. [194]Zhang L; Gao J; Qi A; Gao Y A Novel DRET and FRET Combined Fluorescent Molecule and Its Applications in Sensing and Bioimaging. Sens. Actuators B Chem. 2020, 320, 128457.
  192. [195]Biswas S; Sharma V; Kumar P; Koner AL Selective Sensing of Lysosomal Iron(III) via Three-Component Fluorescence-Based Strategy in Living Cells. Sens. Actuators B Chem. 2018, 260, 460– 464.
  193. [196]Jothi D; Munusamy S; Sawminathan S; Kulathu Iyer S Highly Sensitive Naphthalimide Based Schiff Base for the Fluorimetric Detection of Fe3+. RSC Adv. 2021, 11, 11338– 11346. 35423638 PMC8695811
  194. [197]Rohini G; Ramaiah K; Sreekanth A Naphthalene Dianhydride Based Selective Detection Targetable Fluorescent Probe for Monitoring Exogenous Iron in Living Cells. Tetrahedron Lett. 2018, 59, 3858– 3862.
  195. [198]Hou L; Liu T; Gong Y; Li J; Deng C; Zhang C; Wang Y; Shuang S; Liang W A Turn-on Schiff Base Fluorescent Probe for the Exogenous and Endogenous Fe3+ion Sensing and Bioimaging of Living Cells. New J. Chem. 2020, 44, 19642– 19649.
  196. [199]Liu F; Tang P; Ding R; Liao L; Wang L; Wang M; Wang J A Glycosylation Strategy to Develop a Low Toxic Naphthalimide Fluorescent Probe for the Detection of Fe3+ in Aqueous Medium. Dalton Trans. 2017, 46, 7515– 7522. 28561823
  197. [200]Liu F; Zhu X; Wang Y; Yi Q; Pu C; Luo Y; Wang J; Wang M A Glycocluster Strategy to Develop Dual-Cascade Targeting Fluorescence Probe Detecting Fe3+ in Hepatocyte Mitochondria. Sens. Actuators B Chem. 2023, 374, 132840.
  198. [201]Wang R; Yu F; Liu P; Chen L A Turn-on Fluorescent Probe Based on Hydroxylamine Oxidation for Detecting Ferric Ion Selectively in Living Cells. Chem. Commun. 2012, 48, 5310– 5312. 22511221
  199. [202]Long L; Zhou L; Wang L; Meng S; Gong A; Zhang C A Ratiometric Fluorescent Probe for Iron(III) and Its Application for Detection of Iron(III) in Human Blood Serum. Anal. Chim. Acta 2014, 812, 145– 151. 24491775
  200. [204]Chen YZ; Bhorge YR; Pape AJ; Divate RD; Chung YC; Yen YP A New Schiff Base Chemodosimeter for Fluorescent Imaging of Ferric Ions in Living Cells. J. Fluoresc. 2015, 25, 1331– 1337. 26215081

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Authors
Grover, K., Koblova, A., Pezacki, A. T., Chang, C. J., & New, E. J.
Affiliations
  • The University of Sydney (AU)
  • University of California, Berkeley (US)
Corresponding author
  • Chang, Christopher J.
  • New, Elizabeth J.
ORCID
Venue
Chemical Reviews
Publisher
American Chemical Society (ACS)
Published
2024-04-24
Volume
124
Issue
9
Pages
5846-5929
ISSN
  • 0009-2665 (ISSN-L)
  • 1520-6890
DOI
10.1021/acs.chemrev.3c00819
PMC
PMC11485196
OpenAlex
W4395068743
Cited by
129
References
9
Citations by year
2026: 59 · 2025: 52 · 2024: 18
FWCI
5.46
Type
journal article
Language
en
Open access
Licence
Locations
  • Chemical Reviews (publishedVersion)
  • PubMed (publishedVersion)
  • PubMed Central (acceptedVersion, cc-by-nc-nd)
  • Europe PMC (PubMed Central) (acceptedVersion, cc-by-nc-nd)
  • The Sydney eScholarship Repository (The University of Sydney) (acceptedVersion)
Funders
  • University of Sydney
  • Australian Research Council (CE200100012, DP210102148)
  • National Institutes of Health (ES 28096, GM 139245, GM 79465)
  • Agilent Technologies
Topics
  • Physical Sciences › Chemistry › Spectroscopy › Molecular Sensors and Ion Detection
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Biophysics › Advanced Fluorescence Microscopy Techniques
  • Physical Sciences › Chemical Engineering › Bioengineering › Analytical Chemistry and Sensors
Keywords
metal homeostasis, iron, copper, manganese, cobalt, chromium, nickel, fluorescent probe design
MeSH terms
Animals, Fluorescent Dyes, Humans, Metals, Microscopy, Fluorescence, Oxidation-Reduction, Small Molecule Libraries

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

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