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Generation of Thiocillin Ring Size Variants by Prepeptide Gene Replacement and in Vivo Processing by Bacillus cereus

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Characterization of a Novel Plasmid-Borne Thiopeptide Gene Cluster in Staphylococcus epidermidis Strain 115

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Insights into Quinaldic Acid Moiety Formation in Thiostrepton Biosynthesis Facilitating Fluorinated Thiopeptide Generation

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Capturing Linear Intermediates and C-Terminal Variants during Maturation of the Thiopeptide GE2270

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Fixing the Unfixable: The Art of Optimizing Natural Products for Human Medicine

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Thiostrepton Maturation Involving a Deesterification−Amidation Way To Process the C-Terminally Methylated Peptide Backbone

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Post-translational modifications involved in the biosynthesis of thiopeptide antibiotics

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Opportunities and challenges from current investigations into the biosynthetic logic of nosiheptide-represented thiopeptide antibiotics

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Protein Engineering in Ribosomally Synthesized and Post-translationally Modified Peptides (RiPPs)

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Saturation Mutagenesis of TsrA Ala4 Unveils a Highly Mutable Residue of Thiostrepton A

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Biosynthesis and molecular engineering of templated natural products

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Thiopeptide Pyridine Synthase TbtD Catalyzes an Intermolecular Formal Aza-Diels–Alder Reaction

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Insight into bicyclic thiopeptide biosynthesis benefited from development of a uniform approach for molecular engineering and production improvement

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Engineering of RiPP pathways for the production of artificial peptides bearing various non-proteinogenic structures

Goto, Y., & Suga, H. (2018) · Current Opinion in Chemical Biology · doi:10.1016/j.cbpa.2018.06.014 · Cited by 29 · see citing works

Heterocycles: Versatile control elements in bioactive macrocycles

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Characterization of a Multipeptide Lantibiotic Locus in Streptococcus pneumoniae

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Thiostrepton Variants Containing a Contracted Quinaldic Acid Macrocycle Result from Mutagenesis of the Second Residue

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In Vivo Production of Thiopeptide Variants

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Characterization of Leader Peptide Binding During Catalysis by the Nisin Dehydratase NisB

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Natural thiopeptides as a privileged scaffold for drug discovery and therapeutic development

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Bio-inspired engineering of thiopeptide antibiotics advances the expansion of molecular diversity and utility

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A Heterotrimeric Dehydrogenase Complex Functions with 2 Distinct YcaO Proteins to Install 5 Azole Heterocycles into 35-Membered Sulfomycin Thiopeptides

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Thiocillin and micrococcin exploit the ferrioxamine receptor of Pseudomonas aeruginosa for uptake

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Reconstitution and Minimization of a Micrococcin Biosynthetic Pathway in Bacillus subtilis

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De novo design of ribosomally synthesized and post-translationally modified peptides

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An Update on Lysine Deacylases Targeting the Expanding “Acylome”

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In Vitro Biosynthesis and Substrate Tolerance of the Plantazolicin Family of Natural Products

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Thiopeptides Induce Proteasome-Independent Activation of Cellular Mitophagy

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Mutagenesis of precursor peptide for the generation of nosiheptide analogues

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Elucidating and engineering thiopeptide biosynthesis

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Interception of the Bycroft–Gowland Intermediate in the Enzymatic Macrocyclization of Thiopeptides

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Investigations into PoyH, a promiscuous protease from polytheonamide biosynthesis

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Managing two simultaneous issues in concrete repair: Healing microcracks and controlling pathogens

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Biochemical and biosynthetic preparation of natural product-like cyclic peptide libraries

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Biosynthesis-based artificial evolution of microbial natural products

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Impact of Bacillus cereus on the Human Gut Microbiota in a 3D In Vitro Model

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Characterization of Nocardithiocin Derivatives Produced by Amino Acid Substitution of Precursor Peptide notG

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Dynamic interspecies interactions and robustness in a four‐species model biofilm

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Thiocillin contributes to the ecological fitness of Bacillus cereus ATCC 14579 during interspecies interactions with Myxococcus xanthus

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RiPPs: Ribosomally Synthesized and Posttranslationally Modified Peptides

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The Three Cornerstones of Chemical Biology: Innovative Probes, New Discoveries, and Enabling Tools

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A Framework for the In Vivo Production of Extensively Engineered Thiopeptides

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Genetic and Structural Characterization of Pneumolancidin, a Broad Spectrum Inhibitory Lantibiotic, Produced by Streptococcus pneumoniae.

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SIRT5 Reveals Novel Enzymatic Activities of Sirtuins

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Biomolecular Engineering of Microorganisms for Natural Products Production

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Structural diversity research of natural products based on biosynthetic mechanism

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Minimal lactazole scaffold for in vitro production of pseudo-natural thiopeptidesPreprint

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Chemistry and Chemical Biology of Thiopeptide Natural Products

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L'Effet " Modifications Post-Traductionnelles" : petits groupements chimiques, grandes conséquences? Caractérisation de protéines modifiées chez Pseudomonas aeruginosa PA14 par analyse protéomique.

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Bacteriocin-Producing Probiotics as Precision Antimicrobial Therapeutics: From Lactic Acid Bacteria to Emerging and Engineered Next-Generation Platforms

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Generation of Thiocillin Ring Size Variants by Prepeptide Gene Replacement and in Vivo Processing by Bacillus cereus

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Manipulation of thiocillin variants by prepeptide gene replacement: Structure, conformation, and activity of heterocycle substitution mutants

Bowers, A. A., Koglin, A.-S., Walsh, C. T., & Acker, M. G. (2022) · Carolina Digital Repository (University of North Carolina at Chapel Hill) · doi:10.17615/0406-jz46

Thirteen posttranslational modifications convert a 14-residue peptide into the antibiotic thiocillin

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Saturation Mutagenesis and Structure-Activity Relationship of a Natural Product Antibiotic

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Thiopeptide Biosynthesis Featuring Ribosomally Synthesized Precursor Peptides and Conserved Posttranslational Modifications

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