The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Aminopeptidase N Activatable Fluorescent Probe for Tracking Metastatic Cancer and Image-Guided Surgery via in Situ Spraying
Abstract
The recurrence of malignant tumors is mostly caused by incompleted surgical resection. Especially, it is difficult for surgeons to detect and accurately remove metastatic tumors by predominantly using visual examination and palpation owing to the lack of effective means to specifically distinguish the boundary range between normal and tumor tissues. Thus, the development of activated fluorescent probe with superior tumor-to-normal (T/N) tissue ratios is particularly urgent in clinics. In view of CD13/aminopeptidase N (APN) regarded as a cancer-specific biomarker, mediating with progression, invasion, and migration of malignant tumor, herein, we reported an APN-responsive fluorescent probe YH-APN and demonstrated its application to distinguish cancer cells. Through in situ spraying manner, fluorescent superior tumor-to-normal (T/N) tissue ratios (subcutaneous transplantation tumor, 13.86; hepatic metastasis, 4.42 and 6.25; splenic metastasis, 4.99) were achieved. More importantly, we have demonstrated the ability to image metastasis tumor tissue less than 1 mm in diameter, highlighting the potential for this probe to be used as a tool in surgical resection. This research may spur the use of enzyme-activatable fluorescent probes for the progress of tumor diagnosis and image-guided surgery (IGS).
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Cites
Recent progresses in small-molecule enzymatic fluorescent probes for cancer imaging
Liu, H.-W., Chen, L., Xu, C., Li, Z., Zhang, H., Zhang, X.-B., & Tan, W. (2018) · Chemical Society Reviews · doi:10.1039/c7cs00862g · Cited by 948
Cited by
Near-infrared (NIR) fluorescence-emitting small organic molecules for cancer imaging and therapy
Li, H., Kim, Y., Jung, H., Hyun, J. Y., & Shin, I. (2022) · Chemical Society Reviews · doi:10.1039/d2cs00722c · Cited by 356
Self-citationZeng, S., Liu, X., Kafuti, Y. S., Kim, H., Wang, J., Peng, X., Li, H., & Yoon, J. (2023) · Chemical Society Reviews · doi:10.1039/d2cs00799a · Cited by 341
Self-citationChen, J., Chen, L., Zeng, F., & Wu, S. (2022) · Analytical Chemistry · doi:10.1021/acs.analchem.2c01241 · Cited by 50
Sun, L., Wu, H., Zhang, Z., Wu, K., Sun, J., Dong, X., Dong, C., Zhao, C., Gu, X., & Qu, D. (2025) · Aggregate · doi:10.1002/agt2.70007 · Cited by 39
Activatable Molecular Probes With Clinical Promise for NIR‐II Fluorescent Imaging
Chen, Z., Zhou, Y., Li, L., Ma, W., Li, Y., & Yang, Z. (2025) · Small · doi:10.1002/smll.202411787 · Cited by 26
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Metadata
- Authors
- Li, H., Yao, Q., Sun, W., Shao, K., Lu, Y., Chung, J., Kim, D., Fan, J., Long, S., Du, J., Li, Y., Wang, J., Yoon, J., & Peng, X.
- Venue
- Journal of the American Chemical Society
- Publisher
- American Chemical Society (ACS)
- Published
- 2020-03-13
- Volume
- 142
- Issue
- 13
- Pages
- 6381-6389
- ISSN
- 0002-7863 (ISSN-L)
- 1520-5126
- OpenAlex
- W3011715566
- Cited by
- 302
- References
- 1
- FWCI
- 16.19
- Type
- journal article
- Language
- en
- Open access
- closed
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- Li, H., Yao, Q., Sun, W., Shao, K., Lu, Y., Chung, J., Kim, D., Fan, J., Long, S., Du, J., Li, Y., Wang, J., Yoon, J., & Peng, X. (2020). Aminopeptidase N Activatable Fluorescent Probe for Tracking Metastatic Cancer and Image-Guided Surgery via in Situ Spraying. Journal of the American Chemical Society. https://doi.org/10.1021/jacs.0c01365
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