The DOI matches its Crossref record; 4 of the 4 references it cites were found in a registry or an index.
Visualizing Peroxynitrite Fluxes in Endothelial Cells Reveals the Dynamic Progression of Brain Vascular Injury
Abstract
Accumulating evidence suggests that formation of peroxynitrite (ONOO(-)) in the cerebral vasculature contributes to the progression of ischemic damage, while the underlying molecular mechanisms remain elusive. To fully understand ONOO(-) biology, efficient tools that can realize the real-time tracing of endogenous ONOO(-) fluxes are indispensable. While a few ONOO(-) fluorescent probes have been reported, direct visualization of ONOO(-) fluxes in the cerebral vasculature of live mice remains a challenge. Herein, we present a fluorescent switch-on probe (NP3) for ONOO(-) imaging. NP3 exhibits good specificity, fast response, and high sensitivity toward ONOO(-) both in vitro and in vivo. Moreover, NP3 is two-photon excitable and readily blood-brain barrier penetrable. These desired photophysical and pharmacokinetic properties endow NP3 with the capability to monitor brain vascular ONOO(-) generation after injury with excellent temporal and spatial resolution. As a proof of concept, NP3 has enabled the direct visualization of neurovascular ONOO(-) formation in ischemia progression in live mouse brain by use of two-photon laser scanning microscopy. Due to these favorable properties, NP3 holds great promise for visualizing endogenous peroxynitrite fluxes in a variety of pathophysiological progressions in vitro and in vivo.
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Cites
Peroxynitrite: biochemistry, pathophysiology and development of therapeutics
Szabó, C., Ischiropoulos, H., & Radi, R. (2007) · Nature Reviews Drug Discovery · doi:10.1038/nrd2222 · Cited by 2,134
Chemical biology of peroxynitrite: Kinetics, diffusion, and radicals
Ferrer-Sueta, G., & Radi, R. (2009) · ACS Chemical Biology · doi:10.1021/cb800279q · Cited by 776
Schaffer, C. B., Friedman, B., Nishimura, N., Schroeder, L. F., Tsai, P. S., Ebner, F. F., Lyden, P. D., & Kleinfeld, D. (2006) · PLoS Biology · doi:10.1371/journal.pbio.0040022 · Cited by 400
Nishimura, N., Schaffer, C. B., Friedman, B., Tsai, P. S., Lyden, P. D., & Kleinfeld, D. (2006) · Nature Methods · doi:10.1038/nmeth844 · Cited by 308
Cited by
Nitrates/Nitrites in Food—Risk for Nitrosative Stress and Benefits
Karwowska, M., & Kononiuk, A. (2020) · Antioxidants · doi:10.3390/antiox9030241 · Cited by 360
Wu, L., Liu, J., Li, P., Tang, B., & James, T. D. (2021) · Chemical Society Reviews · doi:10.1039/d0cs00861c · Cited by 348
Cheng, D., Peng, J., Lv, Y., Su, D., Liu, D., Chen, M., Yuan, L., & Zhang, X. (2019) · Journal of the American Chemical Society · doi:10.1021/jacs.9b01374 · Cited by 308
Chen, D.-Y., Sun, N.-H., Lu, Y.-P., Hong, L.-J., Cui, T.-T., Wang, C.-K., Chen, X.-H., Wang, S.-S., Feng, L.-L., Shi, W.-X., et al. (2019) · Theranostics · doi:10.7150/thno.34168 · Cited by 29
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Metadata
- Authors
- Li, X., Tao, R.-R., Hong, L.-J., Cheng, J., Jiang, Q., Lu, Y.-M., Liao, M.-H., Ye, W.-F., Lu, N.-N., Han, F., Hu, Y.-Z., & Hu, Y.-H.
- Venue
- Journal of the American Chemical Society
- Publisher
- American Chemical Society (ACS)
- Published
- 2015-09-18
- Volume
- 137
- Issue
- 38
- Pages
- 12296-12303
- ISSN
- 0002-7863 (ISSN-L)
- 1520-5126
- OpenAlex
- W2276765405
- Cited by
- 214
- References
- 4
- FWCI
- 9.20
- Type
- journal article
- Language
- en
- Open access
- closed
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- Li, X., Tao, R.-R., Hong, L.-J., Cheng, J., Jiang, Q., Lu, Y.-M., Liao, M.-H., Ye, W.-F., Lu, N.-N., Han, F., Hu, Y.-Z., & Hu, Y.-H. (2015). Visualizing Peroxynitrite Fluxes in Endothelial Cells Reveals the Dynamic Progression of Brain Vascular Injury. Journal of the American Chemical Society. https://doi.org/10.1021/jacs.5b06865
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