The DOI matches its Crossref record; 3 of the 3 references it cites were found in a registry or an index.
Endoplasmic Reticulum-Localized Iridium(III) Complexes as Efficient Photodynamic Therapy Agents via Protein Modifications
Abstract
Protein inactivation by reactive oxygen species (ROS) such as singlet oxygen ((1)O2) and superoxide radical (O2(•-)) is considered to trigger cell death pathways associated with protein dysfunction; however, the detailed mechanisms and direct involvement in photodynamic therapy (PDT) have not been revealed. Herein, we report Ir(III) complexes designed for ROS generation through a rational strategy to investigate protein modifications by ROS. The Ir(III) complexes are effective as PDT agents at low concentrations with low-energy irradiation (≤ 1 J cm(-2)) because of the relatively high (1)O2 quantum yield (> 0.78), even with two-photon activation. Furthermore, two types of protein modifications (protein oxidation and photo-cross-linking) involved in PDT were characterized by mass spectrometry. These modifications were generated primarily in the endoplasmic reticulum and mitochondria, producing a significant effect for cancer cell death. Consequently, we present a plausible biologically applicable PDT modality that utilizes rationally designed photoactivatable Ir(III) complexes.
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Cites
Physical Mechanisms of Generation and Deactivation of Singlet Oxygen
Schweitzer, C., & Schmidt, R. (2003) · Chemical Reviews · doi:10.1021/cr010371d · Cited by 2,123
PINK1-dependent recruitment of Parkin to mitochondria in mitophagy
Vives-Bauza, C., Zhou, C., Huang, Y., Cui, M., de Vries, R. L. A., Kim, J., May, J., Tocilescu, M. A., Liu, W., Ko, H. S., et al. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0911187107 · Cited by 1,616
Endoplasmic reticulum-mitochondria contacts: Function of the junction
Rowland, A. A., & Voeltz, G. K. (2012) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm3440 · Cited by 1,018
Cited by
Recent Strategies to Develop Innovative Photosensitizers for Enhanced Photodynamic Therapy
Pham, T. C., Nguyen, V.-N., Choi, Y., Lee, S., & Yoon, J. (2021) · Chemical Reviews · doi:10.1021/acs.chemrev.1c00381 · Cited by 1,813
Self-citationLee, L. C.-C., & Lo, K. K.-W. (2022) · Journal of the American Chemical Society · doi:10.1021/jacs.2c03437 · Cited by 279
Architecture Mapping of the Inner Mitochondrial Membrane Proteome by Chemical Tools in Live Cells
Lee, S.-Y., Kang, M.-G., Shin, S., Kwak, C., Kwon, T., Seo, J. K., Kim, J.-S., & Rhee, H.-W. (2017) · Journal of the American Chemical Society · doi:10.1021/jacs.6b10418 · Cited by 106
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Metadata
- Authors
- Nam, J. S., Kang, M.-G., Kang, J., Park, S.-Y., Lee, S. J. C., Kim, H.-T., Seo, J. K., Kwon, O.-H., Lim, M. H., Rhee, H.-W., & Kwon, T.-H.
- Venue
- Journal of the American Chemical Society
- Publisher
- American Chemical Society (ACS)
- Published
- 2016-08-22
- Volume
- 138
- Issue
- 34
- Pages
- 10968-10977
- ISSN
- 0002-7863 (ISSN-L)
- 1520-5126
- OpenAlex
- W2490932348
- Cited by
- 419
- References
- 3
- FWCI
- 34.16
- Type
- journal article
- Language
- en
- Open access
- closed
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- Nam, J. S., Kang, M.-G., Kang, J., Park, S.-Y., Lee, S. J. C., Kim, H.-T., Seo, J. K., Kwon, O.-H., Lim, M. H., Rhee, H.-W., & Kwon, T.-H. (2016). Endoplasmic Reticulum-Localized Iridium(III) Complexes as Efficient Photodynamic Therapy Agents via Protein Modifications. Journal of the American Chemical Society. https://doi.org/10.1021/jacs.6b05302
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