Endoplasmic reticulum-mitochondria contacts: Function of the junction
Open accessAbstract
The most well-characterized organelle contact sites are those between the endoplasmic reticulum (ER) and mitochondria. Increased understanding is being gained of how ER-mitochondria contact sites are organized and which factors converge at this interface, some of which may provide a tethering function. The role of the ER-mitochondria junction in coordinating the functions of these two organelles is also becoming clearer, and it has been shown to be involved in the regulation of lipid synthesis, Ca(2+) signalling and the control of mitochondrial biogenesis and intracellular trafficking.
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MAM participate in lipid synthesis, membrane stability, mitochondrial dynamics, and ROS signaling.
“Besides controlling Ca2+ flux, MAM participate in lipid synthesis, membrane stability, mitochondrial dynamics, and ROS signaling [99–101].”
From Neuronal Apolipoprotein E4 Expression Results in Proteome-Wide Alterations and Compromises Bioenergetic Capacity by Disrupting Mitochondrial Function (2019) · cites this paper as [99]
The “Lipid exchange during biosynthesis” section says the MAM fraction is enriched in lipid-synthesis enzymes, and “Regulating mitochondrial dynamics and inheritance” links ER–mitochondria contacts to mitochondrial dynamics. The passages do not establish membrane stability or ROS signaling as functions of MAM. (LLM, conf=0.87)
Experimental — accuracy not yet measuredMitochondria shared greater location similarity with the ER (SEC61β and SERCA) than any other structures.
“Mitochondria shared greater location similarity with the ER (SEC61β and SERCA) than any other structures, consistent with the functional interactions between these cellular structures22,23.”
From Integrated intracellular organization and its variations in human iPS cells (2023) · cites this paper as [22]
MAMs play a vital role in lipid transport, Ca2+ signaling, cell survival, and energy metabolism, and have been implicated in diseases including Alzheimer's disease, cancer, lysosomal storage disease, diabetes mellitus, obesity, and metabolic disorders.
“MAMs play a vital role in lipid transport, Ca2+ signaling, cell survival, and energy metabolism [234], and have been implicated in diseases including Alzheimer’s disease [235], cancer [236], lysosomal storage disease [237], diabetes mellitus [238,239], obesity, and metabolic disorders [240].”
From AMPK, Mitochondrial Function, and Cardiovascular Disease (2020) · cites this paper as [234]
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- Authors
- Rowland, A. A., & Voeltz, G. K.
- Affiliations
- University of Colorado Boulder (US)
- Corresponding author
- Voeltz, Gia K.
- ORCID
- Voeltz, Gia K.
- Venue
- Nature Reviews Molecular Cell Biology
- Published
- 2012-09-20
- Volume
- 13
- Issue
- 10
- Pages
- 607-615
- ISSN
- 1471-0072 (ISSN-L)
- 1471-0080
- PMC
- PMC5111635
- OpenAlex
- W2117692658
- Cited by
- 1,018
- References
- 84
- Citations by year
- 2026: 67 · 2025: 81 · 2024: 89 · 2023: 81 · 2022: 81 · 2021: 79 · 2020: 77 · 2019: 68 · 2018: 70 · 2017: 76 · 2016: 67 · 2015: 71 · 2014: 57 · 2013: 51 · 2012: 3
- FWCI
- 5.31
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Nature Reviews Molecular Cell Biology (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institutes of Health
- National Institute of General Medical Sciences (GM07135, R01GM083977, T32GM007135)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Mitochondrial Function and Pathology
- Life Sciences › Neuroscience › Sensory Systems › Ion Channels and Receptors
- Health Sciences › Medicine › Epidemiology › Autophagy in Disease and Therapy
- Keywords
- endoplasmic reticulum-mitochondria contacts, organelle tethering, lipogenesis, calcium signaling, mitochondrial biogenesis, intracellular trafficking
- MeSH terms
- Animals, Endoplasmic Reticulum, Lipids, Mitochondria, Signal Transduction, Calcium Signaling, Protein Transport, Mitochondrial Membranes, Mitochondrial Turnover
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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