The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
FRET-Based Mito-Specific Fluorescent Probe for Ratiometric Detection and Imaging of Endogenous Peroxynitrite: Dyad of Cy3 and Cy5
Abstract
Peroxynitrite (OONO(-)) is profoundly implicated in health and disease. The physiological and pathological outcome of OONO(-) is related to its local concentration, and hence, a reliable OONO(-) assay is highly desired. We have developed a FRET-based small-molecule fluorescent probe (PNCy3Cy5), harnessing the differential reactivity of Cy3 and Cy5 toward OONO(-) by fine-tuning. It exhibits high detection sensitivity and yields a ratiometric fluorescent signal. We have exemplified that it can be applied in semiquantitative determination of OONO(-) in living cells. Notably, it specifically localizes in mitochondria, where endogenous OONO(-) is predominantly generated. Thus, PNCy3Cy5 is a promising molecular tool for peroxynitrite biology.
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Cites
Peroxynitrite: biochemistry, pathophysiology and development of therapeutics
Szabó, C., Ischiropoulos, H., & Radi, R. (2007) · Nature Reviews Drug Discovery · doi:10.1038/nrd2222 · Cited by 2,134
Cited by
Zielonka, J., Joseph, J., Sikora, A., Hardy, M., Ouari, O., Vasquez-Vivar, J., Cheng, G., Lopez, M., & Kalyanaraman, B. (2017) · Chemical Reviews · doi:10.1021/acs.chemrev.7b00042 · Cited by 1,683
Fluorescent probes for organelle-targeted bioactive species imaging
Gao, P., Pan, W., Li, N., & Tang, B. (2019) · Chemical Science · doi:10.1039/c9sc01652j · Cited by 599
Lei, Z., Sun, C., Pei, P., Wang, S., Li, D., Zhang, X., & Zhang, F. (2019) · Angewandte Chemie International Edition · doi:10.1002/anie.201904182 · Cited by 362
Zeng, S., Liu, X., Kafuti, Y. S., Kim, H., Wang, J., Peng, X., Li, H., & Yoon, J. (2023) · Chemical Society Reviews · doi:10.1039/d2cs00799a · Cited by 341
Near infrared fluorescent probes for detecting and imaging active small molecules
Ding, C., & Ren, T. (2023) · Coordination Chemistry Reviews · doi:10.1016/j.ccr.2023.215080 · Cited by 247
Metadata
- Authors
- Jia, X., Chen, Q., Yang, Y., Tang, Y., Wang, R., Xu, Y., Zhu, W., & Qian, X.
- Venue
- Journal of the American Chemical Society
- Publisher
- American Chemical Society (ACS)
- Published
- 2016-08-22
- Volume
- 138
- Issue
- 34
- Pages
- 10778-10781
- ISSN
- 0002-7863 (ISSN-L)
- 1520-5126
- OpenAlex
- W2514279849
- Cited by
- 341
- References
- 1
- FWCI
- 21.34
- Type
- journal article
- Language
- en
- Open access
- closed
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