Stable, Wavelength‐Tunable Fluorescent Dyes in the NIR‐II Region for In Vivo High‐Contrast Bioimaging and Multiplexed Biosensing
Abstract
Small‐molecule organic fluorophores, spectrally active in the 900–1700 nm region, with tunable wavelength and sensing properties are sought‐after for in vivo optical imaging and biosensing. A panel of fluorescent dyes (CX) has been developed to meet this challenge. CX dyes exhibit the wavelength tunability of cyanine dyes and have a rigidified polymethine chain to guarantee their stability. They are chemo‐ and photo‐stable in an aqueous environment and have tunable optical properties with maximal absorbing/emitting wavelength at 1089/1140 nm. They show great potential in high‐contrast in vivo bioimaging and multicolor detection with negligible optical cross talk. Förster resonance energy transfer (FRET) between CX dyes was demonstrated in deep tissue, providing an approach for monitoring drug‐induced hepatotoxicity by detection of OONO−. This report presents a series of NIR‐II dyes with promising spectroscopic properties for high‐contrast bioimaging and multiplexed biosensing.
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CX-dyes (abs/em: 1089-1140 nm) have much improved stability in an aqueous environment.
“This structural modification led to the development of CX-dyes (abs/em: 1089–1140 nm) with much improved stability in an aqueous environment.37”
Bridging large rigid heterocyclic systems with a short polymethine chain allows expansion of the overall π-conjugation system while maintaining structural stiffness.
“One of the very promising ways of structural modifications is to bridge large rigid heterocyclic systems with a short polymethine chain, which allows an expansion of the overall π-conjugation system while maintaining its structural stiffness.”
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- Authors
- Lei, Z., Sun, C., Pei, P., Wang, S., Li, D., Zhang, X., & Zhang, F.
- Affiliations
- Fudan University (CN)
- Corresponding author
- Zhang, Fan
- Venue
- Angewandte Chemie International Edition
- Publisher
- Wiley
- Published
- 2019-05-08
- Volume
- 58
- Issue
- 24
- Pages
- 8166-8171
- ISSN
- 1433-7851 (ISSN-L)
- 1521-3773
- OpenAlex
- W2940791135
- Cited by
- 362
- References
- 62
- Citations by year
- 2026: 21 · 2025: 38 · 2024: 37 · 2023: 45 · 2022: 62 · 2021: 76 · 2020: 66 · 2019: 16
- FWCI
- 19.86
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Angewandte Chemie International Edition (publishedVersion)
- PubMed (publishedVersion)
- Funders
- China Postdoctoral Science Foundation (KLH1615169)
- National Postdoctoral Program for Innovative Talents (VLH1615002)
- Topics
- Physical Sciences › Materials Science › Materials Chemistry › Luminescence and Fluorescent Materials
- Physical Sciences › Chemistry › Spectroscopy › Molecular Sensors and Ion Detection
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Biophysics › Advanced Fluorescence Microscopy Techniques
- Keywords
- cyanine dyes, polymethine chain, in vivo imaging, multiplexed biosensing, fluorescence resonance energy transfer, deep tissue imaging, hepatotoxicity monitoring, peroxynitrite detection, photostability
- MeSH terms
- Fluorescent Dyes, Biosensing Techniques, Nanoparticles, Optical Imaging
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