The DOI matches its Crossref record; 45 of the 45 references it cites were found in a registry or an index.
Mitochondria Targeted Nanoscale Zeolitic Imidazole Framework-90 for ATP Imaging in Live Cells
Abstract
Zeolitic imidazole frameworks (ZIFs) are an emerging class of functional porous materials with promising biomedical applications such as molecular sensing and intracellular drug delivery. We report herein the first example of using nanoscale ZIFs (i.e., ZIF-90), self-assembled from Zn 2+ and imidazole-2-carboxyaldehyde, to target subcellular mitochondria and image dynamics of mitochondrial ATP in live cells. Encapsulation of fluorescent Rhodamine B (RhB) into ZIF-90 suppresses the emission of RhB, while the competitive coordination between ATP and the metal node of ZIF-90 dissembles ZIFs, resulting in the release of RhB for ATP sensing. With this method, we are able to image mitochondrial ATP in live cells and study the ATP level fluctuation in cellular glycolysis and apoptosis processes. The strategy reported here could be further extended to tune nanoscale ZIFs inside live cells for targeted delivery of therapeutics to subcellular organelles for advanced biomedical applications.
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Cited by
Alsaiari, S. K., Patil, S., Alyami, M., Alamoudi, K. O., Aleisa, F. A., Merzaban, J. S., Li, M., & Khashab, N. M. (2018) · Journal of the American Chemical Society · doi:10.1021/jacs.7b11754 · Cited by 517
Chen, T.-T., Yi, J.-T., Zhao, Y.-Y., & Chu, X. (2018) · Journal of the American Chemical Society · doi:10.1021/jacs.8b04457 · Cited by 462
Zhou, Z., Vázquez-González, M., & Willner, I. (2021) · Chemical Society Reviews · doi:10.1039/d0cs01030h · Cited by 308
Metal-Organic Framework (MOF)-Based Drug Delivery
Cao, J., Li, X., & Tian, H. (2020) · Current Medicinal Chemistry · doi:10.2174/0929867326666190618152518 · Cited by 282
Gao, J., Li, J., Geng, W.-C., Chen, F.-Y., Duan, X., Zheng, Z., Ding, D., & Guo, D.-S. (2018) · Journal of the American Chemical Society · doi:10.1021/jacs.8b02331 · Cited by 266
Metadata
- Authors
- Deng, J., Wang, K., Wang, M., Yu, P., & Mao, L.
- Venue
- Journal of the American Chemical Society
- Publisher
- American Chemical Society (ACS)
- Published
- 2017-04-14
- Volume
- 139
- Issue
- 16
- Pages
- 5877-5882
- ISSN
- 0002-7863 (ISSN-L)
- 1520-5126
- OpenAlex
- W2604582212
- Cited by
- 398
- References
- 45
- FWCI
- 12.07
- Type
- journal article
- Language
- en
- Open access
- closed
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