The DOI matches its Crossref record; 29 of the 29 references it cites were found in a registry or an index.
Construction of a Multiple-Aptamer-Based DNA Logic Device on Live Cell Membranes via Associative Toehold Activation for Accurate Cancer Cell Identification
Abstract
The ability to accurately identify and isolate cells is the cornerstone of precise disease diagnosis and therapies. A single-step cell identification method based on logic analysis of multiple surface markers will have unique advantages because of its accuracy and efficacy. Herein, using multiple DNA aptamers for cancer biomarker recognition and associative toehold activation for signal integration and amplification as two molecular keys, we have successfully operated a cell-surface device that can perform AND Boolean logic analysis of multiple biomarkers and precisely label the target cell subtype in large populations of similar cells via the presence or absence of different biomarkers. Our approach can achieve single-step cancer cell identification and isolation with excellent sensitivity and accuracy and thus will have broad applications in biological science, biomedical engineering, and personalized medicine.
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Cited by
Xiong, Y., Zhang, J., Yang, Z., Mou, Q., Ma, Y., Xiong, Y., & Lu, Y. (2020) · Journal of the American Chemical Society · doi:10.1021/jacs.9b09211 · Cited by 689
Metadata
- Authors
- Chang, X., Zhang, C., Lv, C., Sun, Y., Zhang, M., Zhao, Y., Yang, L., Han, D., & Tan, W.
- Venue
- Journal of the American Chemical Society
- Publisher
- American Chemical Society (ACS)
- Published
- 2019-07-21
- Volume
- 141
- Issue
- 32
- Pages
- 12738-12743
- ISSN
- 0002-7863 (ISSN-L)
- 1520-5126
- OpenAlex
- W2963139878
- Cited by
- 312
- References
- 29
- FWCI
- 11.39
- Type
- journal article
- Language
- en
- Open access
- closed
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- Chang, X., Zhang, C., Lv, C., Sun, Y., Zhang, M., Zhao, Y., Yang, L., Han, D., & Tan, W. (2019). Construction of a Multiple-Aptamer-Based DNA Logic Device on Live Cell Membranes via Associative Toehold Activation for Accurate Cancer Cell Identification. Journal of the American Chemical Society. https://doi.org/10.1021/jacs.9b05470
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
