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The DOI matches its Crossref record; 5 of the 5 references it cites were found in a registry or an index.

Triggered amplification by hybridization chain reaction

Open access
Dirks, Robert M., Pierce, Niles A.·2004·Proceedings of the National Academy of Sciences

Abstract

We introduce the concept of hybridization chain reaction (HCR), in which stable DNA monomers assemble only upon exposure to a target DNA fragment. In the simplest version of this process, two stable species of DNA hairpins coexist in solution until the introduction of initiator strands triggers a cascade of hybridization events that yields nicked double helices analogous to alternating copolymers. The average molecular weight of the HCR products varies inversely with initiator concentration. Amplification of more diverse recognition events can be achieved by coupling HCR to aptamer triggers. This functionality allows DNA to act as an amplifying transducer for biosensing applications.

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Metadata

Authors
Dirks, R. M., & Pierce, N. A.
Venue
Proceedings of the National Academy of Sciences
Published
2004-10-18
Volume
101
Issue
43
Pages
15275-15278
ISSN
  • 0027-8424 (ISSN-L)
  • 1091-6490
OpenAlex
W2148304424
Cited by
2,063
References
5
FWCI
2.84
Type
journal article
Language
en
Open access
green

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CoChat. (2026). Citation check: Triggered amplification by hybridization chain reaction. https://app.cochat.ai/papers/10.1073/pnas.0407024101
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Dirks, R. M., & Pierce, N. A. (2004). Triggered amplification by hybridization chain reaction. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.0407024101

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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.