The DOI matches its Crossref record; 3 of the 3 references it cites were found in a registry or an index.
Ferroptosis Accompanied by •OH Generation and Cytoplasmic Viscosity Increase Revealed via Dual-Functional Fluorescence Probe
Abstract
Ferroptosis, a new form of regulated cell death, results from the iron-dependent accumulation of lipid peroxides that are associated with reactive oxygen species. However, it remains unclear how hydroxyl radical ( • OH) and cellular microenvironments such as viscosity alter in this process. Herein, we characterize for the first time the changing behavior of • OH and cytoplasmic viscosity during ferroptosis using a dual-functional fluorescence probe (H–V) that is designed via the molecular rotor strategy and the unique aromatic hydroxylation of • OH. Probe H–V shows completely separate spectral responses to • OH and viscosity with high sensitivity and selectivity, thereby achieving the detection of • OH and viscosity in two independent channels without spectral cross-interference. With the probe we find that ferroptosis is accompanied by significant • OH generation and cytoplasmic viscosity increase. Most notably, the raised • OH comprises the majority of the total reactive oxygen species in ferroptosis. H–V is biocompatible, ready to prepare, and may be expected to be used in the study of viscosity and • OH detection in more biosystems.
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Cites
Regulation of Ferroptotic Cancer Cell Death by GPX4
Yang, W. S., SriRamaratnam, R., Welsch, M. E., Shimada, K., Skouta, R., Viswanathan, V. S., Cheah, J. H., Clemons, P. A., Shamji, A. F., Clish, C. B., et al. (2014) · Cell · doi:10.1016/j.cell.2013.12.010 · Cited by 7,713
Ferroptosis: A Regulated Cell Death Nexus Linking Metabolism, Redox Biology, and Disease
Stockwell, B. R., Friedmann Angeli, J. P., Bayir, H., Bush, A. I., Conrad, M., Dixon, S. J., Fulda, S., Gascón, S., Hatzios, S. K., Kagan, V. E., et al. (2017) · Cell · doi:10.1016/j.cell.2017.09.021 · Cited by 7,695
Futatsugi, K., Kung, D. W., Orr, S. T. M., Cabral, S., Hepworth, D., Aspnes, G., Bader, S., Bian, J., Boehm, M., Carpino, P. A., et al. (2015) · Journal of Medicinal Chemistry · doi:10.1021/acs.jmedchem.5b01006 · Cited by 88
Cited by
Yin, J., Huang, L., Wu, L., Li, J., James, T. D., & Lin, W. (2021) · Chemical Society Reviews · doi:10.1039/d1cs00645b · Cited by 549
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Wu, L., Huang, J., Pu, K., & James, T. D. (2021) · Nature Reviews Chemistry · doi:10.1038/s41570-021-00277-2 · Cited by 328
Near infrared fluorescent probes for detecting and imaging active small molecules
Ding, C., & Ren, T. (2023) · Coordination Chemistry Reviews · doi:10.1016/j.ccr.2023.215080 · Cited by 247
Simvastatin induced ferroptosis for triple-negative breast cancer therapy
Yao, X., Xie, R., Cao, Y., Tang, J., Men, Y., Peng, H., & Yang, W. (2021) · Journal of Nanobiotechnology · doi:10.1186/s12951-021-01058-1 · Cited by 227
Xanthene-Based NIR-II Dyes for In Vivo Dynamic Imaging of Blood Circulation
Liu, D., He, Z., Zhao, Y., Yang, Y., Shi, W., Li, X., & Ma, H. (2021) · Journal of the American Chemical Society · doi:10.1021/jacs.1c07711 · Cited by 217
Self-citation
Metadata
- Authors
- Li, H., Shi, W., Li, X., Hu, Y., Fang, Y., & Ma, H.
- Venue
- Journal of the American Chemical Society
- Publisher
- American Chemical Society (ACS)
- Published
- 2019-10-23
- Volume
- 141
- Issue
- 45
- Pages
- 18301-18307
- ISSN
- 0002-7863 (ISSN-L)
- 1520-5126
- OpenAlex
- W2981535244
- Cited by
- 333
- References
- 3
- FWCI
- 13.58
- Type
- journal article
- Language
- en
- Open access
- closed
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