The DOI matches its Crossref record; 12 of the 12 references it cites were found in a registry or an index.
Green Tea Polyphenols Inhibit the Sodium-Dependent Glucose Transporter of Intestinal Epithelial Cells by a Competitive Mechanism
Abstract
Intestinal glucose uptake is mainly performed by the sodium-dependent glucose transporter, SGLT1. The transport activity of SGLT1 was markedly inhibited by green tea polyphenols, this inhibitory activity being most pronounced in polyphenols having galloyl residues such as epicatechin gallate (ECg) and epigallocatechin gallate (EGCg). Experiments using brush-border membrane vesicles obtained from the rabbit small intestine demonstrated that ECg inhibited SGLT1 in a competitive manner, although ECg itself was not transported via SGLT1. The present results suggest that tea polyphenols such as ECg interact with SGLT1 as antagonist-like molecules, possibly playing a role in controlling the dietary glucose uptake in the intestinal tract.
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Cited by
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Diet-Derived Phenols in Plasma and Tissues and their Implications for Health
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Pulse Consumption, Satiety, and Weight Management
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Metadata
- Authors
- Kobayashi, Y., Suzuki, M., Satsu, H., Arai, S., Hara, Y., Suzuki, K., Miyamoto, Y., & Shimizu, M.
- Venue
- Journal of Agricultural and Food Chemistry
- Publisher
- American Chemical Society (ACS)
- Published
- 2000-10-10
- Volume
- 48
- Issue
- 11
- Pages
- 5618-5623
- ISSN
- 0021-8561 (ISSN-L)
- 1520-5118
- OpenAlex
- W2052275076
- Cited by
- 386
- References
- 12
- FWCI
- 4.57
- Type
- journal article
- Language
- en
- Open access
- closed
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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