The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Peroxidase-Mediated Cross-Linking of a Tyrosine-Containing Peptide with Ferulic Acid
Open accessAbstract
The tyrosine-containing peptide Gly-Tyr-Gly (GYG) was oxidatively cross-linked by horseradish peroxidase in the presence of hydrogen peroxide. As products, covalently coupled di- to pentamers of the peptide were identified by LC-MS. Oxidative cross-linking of ferulic acid with horseradish peroxidase and hydrogen peroxide resulted in the formation of dehydrodimers. Kinetic studies of conversion rates of either the peptide or ferulic acid revealed conditions that allow formation of heteroadducts of GYG and ferulic acid. To a GYG-containing incubation mixture was added ferulic acid in small aliquots, therewith keeping the molar ratio of the substrates favorable for hetero-cross-linking. This resulted in a predominant product consisting of two ferulic acid molecules dehydrogenatively linked to a single peptide and, furthermore, two ferulic acids linked to peptide oligomers, ranging from dimers to pentamers. Also, mono- and dimers of the peptide were linked to one molecule of ferulic acid. A mechanism explaining the formation of all these products is proposed.
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Cites
Antioxidant potential of ferulic acid
Graf, E. (1992) · Free Radical Biology and Medicine · doi:10.1016/0891-5849(92)90184-i · Cited by 1,115
Cited by
Ferulic acid: pharmaceutical functions, preparation and applications in foods
Ou, S., & Kwok, K. (2004) · Journal of the Science of Food and Agriculture · doi:10.1002/jsfa.1873 · Cited by 869
Characterisation of ferulic acid incorporated starch–chitosan blend films
Mathew, S., & Abraham, T. E. (2008) · Food Hydrocolloids · doi:10.1016/j.foodhyd.2007.03.012 · Cited by 366
Biodegradable Soy Protein Isolate-Based Materials: A Review
Song, F., Tang, D.-L., Wang, X.-L., & Wang, Y.-Z. (2011) · Biomacromolecules · doi:10.1021/bm200904x · Cited by 364
Lee, F., Chung, J. E., & Kurisawa, M. (2008) · Soft Matter · doi:10.1039/b719557e · Cited by 300
Horseradish peroxidase (HRP) as a tool in green chemistry
Lopes, G. R., Pinto, D. C. G. A., & Silva, A. M. S. (2014) · RSC Adv. · doi:10.1039/c4ra06094f · Cited by 154
Metadata
- Authors
- Oudgenoeg, G., Hilhorst, R., Piersma, S. R., Boeriu, C. G., Gruppen, H., Hessing, M., Voragen, A. G. J., & Laane, C.
- Venue
- Journal of Agricultural and Food Chemistry
- Publisher
- American Chemical Society (ACS)
- Published
- 2001-04-17
- Volume
- 49
- Issue
- 5
- Pages
- 2503-2510
- ISSN
- 0021-8561 (ISSN-L)
- 1520-5118
- OpenAlex
- W2032025409
- Cited by
- 159
- References
- 1
- FWCI
- 2.39
- Type
- journal article
- Language
- en
- Open access
- green
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- Oudgenoeg, G., Hilhorst, R., Piersma, S. R., Boeriu, C. G., Gruppen, H., Hessing, M., Voragen, A. G. J., & Laane, C. (2001). Peroxidase-Mediated Cross-Linking of a Tyrosine-Containing Peptide with Ferulic Acid. Journal of Agricultural and Food Chemistry. https://doi.org/10.1021/jf000906o
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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