Antioxidant potential of ferulic acid
Abstract
Ferulic acid is a ubiquitous plant constituent that arises from the metabolism of phenylalanine and tyrosine. It occurs primarily in seeds and leaves both in its free form and covalently linked to lignin and other biopolymers. Due to its phenolic nucleus and an extended side chain conjugation, it readily forms a resonance stabilized phenoxy radical which accounts for its potent antioxidant potential. UV absorption by ferulic acid catalyzes stable phenoxy radical formation and thereby potentiates its ability to terminate free radical chain reactions. By virtue of effectively scavenging deleterious radicals and suppressing radiation-induced oxidative reactions, ferulic acid may serve an important antioxidant function in preserving physiological integrity of cells exposed to both air and impinging UV radiation. Similar photoprotection is afforded to skin by ferulic acid dissolved in cosmetic lotions. Its addition to foods inhibits lipid peroxidation and subsequent oxidative spoilage. By the same mechanism ferulic acid may protect against various inflammatory diseases. A number of other industrial applications are based on the antioxidant potential of ferulic acid.
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Ferulic acid absorbs UV radiation with an absorption maximum at 307 nm (log e = 4.19).
“Ferulic acid absorbs UV radiation with an absorption maximum at 307 nm (log e ¼ 4.19) (Graf, 1992).”
From Ferulic Acid Stabilizes a Solution of Vitamins C and E and Doubles its Photoprotection of Skin (2005) · cites this paper as Graf, 1992
Ferulic acid is a potent phenolic antioxidant found ubiquitously and at high concentrations in plants.
“Ferulic acid is a potent phenolic antioxidant found ubiquitously and at high concentrations in plants (Graf, 1992;Rice-Evans et al, 1996;Ou and Kwok, 2004).”
From Ferulic Acid Stabilizes a Solution of Vitamins C and E and Doubles its Photoprotection of Skin (2005) · cites this paper as Graf, 1992
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- Authors
- Graf, E.
- Corresponding author
- Graf, Ernst
- Venue
- Free Radical Biology and Medicine
- Publisher
- Elsevier BV
- Published
- 1992-10
- Volume
- 13
- Issue
- 4
- Pages
- 435-448
- ISSN
- 0891-5849 (ISSN-L)
- OpenAlex
- W2068315260
- Cited by
- 1,115
- References
- 1
- Citations by year
- 2026: 27 · 2025: 21 · 2024: 29 · 2023: 41 · 2022: 49 · 2021: 41 · 2020: 62 · 2019: 55 · 2018: 51 · 2017: 45 · 2016: 36 · 2015: 50 · 2014: 36 · 2013: 61 · 2012: 61
- FWCI
- 4.33
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Free Radical Biology and Medicine (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Biochemistry › Phytochemicals and Antioxidant Activities
- Physical Sciences › Chemistry › Organic Chemistry › Free Radicals and Antioxidants
- Health Sciences › Medicine › Biochemistry › Antioxidant Activity and Oxidative Stress
- Keywords
- ferulic acid, antioxidant activity, phenoxyl radicals, free radical scavenging, ultraviolet radiation, photoprotection, skin protection, lipid peroxidation, oxidative spoilage, anti-inflammatory activity, lignin, phenolic compounds, cosmetic lotion, food additives
- MeSH terms
- Animals, Antioxidants, Coumaric Acids, Humans, Plants, Free Radical Scavengers
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