The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Inhibitory Effects of Anthocyanins and Other Phenolic Compounds on Nitric Oxide Production in LPS/IFN-γ-Activated RAW 264.7 Macrophages
Abstract
Flavonoids have been reported to lower oxidative stress and possess beneficial effects on cardiovascular diseases and chronic inflammatory diseases associated with nitric oxide (NO). Common phenolic compounds, including phenolic acids, flavonols, isoflavones, and anthocyanins, present in fruits were investigated for their effects on NO production in LPS/IFN-gamma-activated RAW 264.7 macrophages. Phenolic compounds at the range of 16-500 microM that inhibited NO production by > 50% without showing cytotoxicity were the flavonols quercetin and myricetin, the isoflavone daidzein, and the anthocyanins/anthocyanidins pelargonidin, cyanidin, delphinidin, peonidin, malvidin, malvidin 3-glucoside, and malvidin 3,5-diglucosides. Anthocyanins had strong inhibitory effects on NO production. Anthocyanin-rich crude extracts and concentrates of selected berries were also assayed, and their inhibitory effects on NO production were significantly correlated with total phenolic and anthocyanin contents. This is the first study to report the inhibitory effects of anthocyanins and berry phenolic compounds on NO production.
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Cites
Advances in flavonoid research since 1992
Harborne, J. B., & Williams, C. A. (2000) · Phytochemistry · doi:10.1016/s0031-9422(00)00235-1 · Cited by 3,956
Cited by
Hooper, L., Kroon, P. A., Rimm, E. B., Cohn, J. S., Harvey, I., Le Cornu, K. A., Ryder, J. J., Hall, W. L., & Cassidy, A. (2008) · The American Journal of Clinical Nutrition · doi:10.1093/ajcn/88.1.38 · Cited by 1,097
Shih, P.-H., Yeh, C.-T., & Yen, G.-C. (2007) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf071933i · Cited by 334
Cherry Antioxidants: From Farm to Table
Ferretti, G., Bacchetti, T., Belleggia, A., & Neri, D. (2010) · Molecules · doi:10.3390/molecules15106993 · Cited by 320
Panich, U., Tangsupa-a-nan, V., Onkoksoong, T., Kongtaphan, K., Kasetsinsombat, K., Akarasereenont, P., & Wongkajornsilp, A. (2011) · Archives of Pharmacal Research · doi:10.1007/s12272-011-0515-3 · Cited by 127
Fang, C., Kim, H., Noratto, G., Sun, Y., Talcott, S. T., & Mertens-Talcott, S. U. (2018) · Journal of Functional Foods · doi:10.1016/j.jff.2018.04.043 · Cited by 46
Metadata
- Authors
- Wang, J., & Mazza, G.
- Venue
- Journal of Agricultural and Food Chemistry
- Publisher
- American Chemical Society (ACS)
- Published
- 2002-01-09
- Volume
- 50
- Issue
- 4
- Pages
- 850-857
- ISSN
- 0021-8561 (ISSN-L)
- 1520-5118
- OpenAlex
- W1994694127
- Cited by
- 270
- References
- 1
- FWCI
- 5.60
- Type
- journal article
- Language
- en
- Open access
- closed
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