Gallotannin derivatives from mango ( Mangifera indica L.) suppress adipogenesis and increase thermogenesis in 3T3-L1 adipocytes in part through the AMPK pathway
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M. indica peel extracts effectively hinder adipogenesis in vitro in a dose-dependent manner in 3T3-L1 adipocytes via AMPK signaling.
“In this way, Taing et al. [82] and Fang et al. [81] concluded that extracts from M. indica peel effectively hinder adipogenesis in vitro in a dose-dependent manner by suppressing mitotic clonal expansion, genes linked to mitochondrial biogenesis, and fatty acid oxidation in 3T3-L1 adipocytes via AMP-activated protein kinase (AMPK) signaling.”
From Mangifera indica L., By-Products, and Mangiferin on Cardio-Metabolic and Other Health Conditions: A Systematic Review (2023) · cites this paper as [81]
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The dose-dependent pteryxin-mediated molecular mechanisms in suppressing adipogenesis in vitro
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Hsu, C.-Y., Liao, C.-C., Lin, Z.-C., Alalaiwe, A. S., Hwang, E., Lin, T.-W., & Fang, J.-Y. (2024) · Figshare · doi:10.6084/m9.figshare.25150645
Liu, J., Zhang, M., Liu, S., Guo, Y., Yang, Z., Miao, Z., Jiang, M., Wu, L., & Wang, S. (2026) · Food Bioscience · doi:10.1016/j.fbio.2026.108518
- Authors
- Fang, C., Kim, H., Noratto, G., Sun, Y., Talcott, S. T., & Mertens-Talcott, S. U.
- Affiliations
- Texas A&M University (US)
- Venue
- Journal of Functional Foods
- Publisher
- Elsevier BV
- Published
- 2018-07
- Volume
- 46
- Pages
- 101-109
- ISSN
- 1756-4646 (ISSN-L)
- OpenAlex
- W2800190167
- Cited by
- 46
- References
- 52
- Citations by year
- 2026: 2 · 2024: 6 · 2023: 4 · 2022: 6 · 2021: 7 · 2020: 7 · 2019: 9 · 2018: 5
- FWCI
- 9.63
- Type
- journal article
- Language
- en
- Open access
- green
- doaj.org
- Licence
- Locations
- Journal of Functional Foods (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Funders
- COALS’s Nutrition Obesity Strategic Fellowship
- Topics
- Health Sciences › Medicine › Complementary and alternative medicine › Mangiferin and Mango Extracts
- Health Sciences › Medicine › Physiology › Adipose Tissue and Metabolism
- Health Sciences › Medicine › Epidemiology › Adipokines, Inflammation, and Metabolic Diseases
- Keywords
- pyrogallol, adipogenesis, thermogenesis, AMPK signaling, 3T3-L1 adipocytes, adipocyte browning, UCP1, SIRT1, PPARγ, C/EBPα, obesity, lipid metabolism, anti-adipogenic activity
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