The DOI matches its Crossref record; 27 of the 27 references it cites were found in a registry or an index.
Major Flavonoids in Grape Seeds and Skins: Antioxidant Capacity of Catechin, Epicatechin, and Gallic Acid
Abstract
Grape seeds and skins are good sources of phytochemicals such as gallic acid, catechin, and epicatechin and are suitable raw materials for the production of antioxidative dietary supplements. The differences in levels of the major monomeric flavanols and phenolic acids in seeds and skins from grapes of Vitis vinifera varieties Merlot and Chardonnay and in seeds from grapes of Vitis rotundifolia variety Muscadine were determined, and the antioxidant activities of these components were assessed. The contribution of the major monomeric flavonols and phenolic acid to the total antioxidant capacity of grape seeds and skins was also determined. Gallic acid, monomeric catechin, and epicatechin concentrations were 99, 12, and 96 mg/100 g of dry matter (dm) in Muscadine seeds, 15, 358, and 421 mg/100 g of dm in Chardonnay seeds, and 10, 127, and 115 mg/100 g of dm in Merlot seeds, respectively. Concentrations of these three compounds were lower in winery byproduct grape skins than in seeds. These three major phenolic constituents of grape seeds contributed <26% to the antioxidant capacity measured as ORAC on the basis of the corrected concentrations of gallic acid, catechin, and epicatechin in grape byproducts. Peroxyl radical scavenging activities of phenolics present in grape seeds or skins in decreasing order were resveratrol > catechin > epicatechin = gallocatechin > gallic acid = ellagic acid. The results indicated that dimeric, trimeric, oligomeric, or polymeric procyanidins account for most of the superior antioxidant capacity of grape seeds.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Assessing Antioxidant and Prooxidant Activities of Phenolic Compounds
Fukumoto, L. R., & Mazza, G. (2000) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf000220w · Cited by 1,660
Morel, I., Lescoat, G., Cogrel, P., Sergent, O., Pasdeloup, N., Brissot, P., Cillard, P., & Cillard, J. (1993) · Biochemical Pharmacology · doi:10.1016/0006-2952(93)90371-3 · Cited by 635
Antioxidant activity of flavonoids and reactivity with peroxy radical
Torel, J., Cillard, J., & Cillard, P. (1986) · Phytochemistry · doi:10.1016/s0031-9422(00)85485-0 · Cited by 602
Potential health impacts of excessive flavonoid intake
Skibola, C. F., & Smith, M. T. (2000) · Free Radical Biology and Medicine · doi:10.1016/s0891-5849(00)00304-x · Cited by 569
Polymeric proanthocyanidins from grape skins
Souquet, J.-M., Cheynier, V., Brossaud, F., & Moutounet, M. (1996) · Phytochemistry · doi:10.1016/0031-9422(96)00301-9 · Cited by 522
Sánchez-Moreno, C., A. Larrauri, J., & Saura-Calixto, F. (1999) · Food Research International · doi:10.1016/s0963-9969(99)00097-6 · Cited by 472
Yamakoshi, J., Kataoka, S., Koga, T., & Ariga, T. (1999) · Atherosclerosis · doi:10.1016/s0021-9150(98)00230-5 · Cited by 364
Mechanism of inhibition of tannic acid and related compounds on the growth of intestinal bacteria
Chung, K.-T., Lu, Z., & Chou, M. W. (1998) · Food and Chemical Toxicology · doi:10.1016/s0278-6915(98)00086-6 · Cited by 337
Revilla, E., & Ryan, J.-M. (2000) · Journal of Chromatography A · doi:10.1016/s0021-9673(00)00269-7 · Cited by 228
Evaluation of the Antioxidant Actions of Ferulic Acid and Catechins
Scott, B. C., Butler, J., Halliwell, B., & Aruoma, O. I. (1993) · Free Radical Research Communications · doi:10.3109/10715769309056512 · Cited by 223
Resveratrol inhibition of lipid peroxidation
Tadolini, B., Juliano, C., Piu, L., Franconi, F., & Cabrini, L. (2000) · Free Radical Research · doi:10.1080/10715760000300661 · Cited by 217
Sato, M., Bagchi, D., Tosaki, A., & Das, D. K. (2001) · Free Radical Biology and Medicine · doi:10.1016/s0891-5849(01)00626-8 · Cited by 198
Catechin and Procyanidin Composition of Seeds from Grape Cultivars Grown in Ontario
Fuleki, T., & Ricardo da Silva, J. M. (1997) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf960493k · Cited by 197
Cardioprotective Effects of Grape Seed Proanthocyanidin Against Ischemic Reperfusion Injury
Sato, M., Maulik, G., Ray, P. S., Bagchi, D., & Das, D. K. (1999) · Journal of Molecular and Cellular Cardiology · doi:10.1006/jmcc.1999.0961 · Cited by 178
Characterization of procyanidins of Vitis vinifera variety Tinta del Pais grape seeds
Escribano-Bailón, M. T., Fernández, Y. G., Rivas-Gonzalo, J. C., & Santos‐Buelga, C. (1992) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf00022a013 · Cited by 161
Structure-activity relationships governing antioxidant capacities of plant polyphenols
(2001) · Methods in Enzymology · doi:10.1016/s0076-6879(01)35241-2 · Cited by 160
Extraction of polyphenolic compounds from grape seeds with near critical carbon dioxide
Palma, M., & Taylor, L. T. (1999) · Journal of Chromatography A · doi:10.1016/s0021-9673(99)00569-5 · Cited by 150
Comparative flavan-3-ol composition of seeds from different grape varieties
Santos‐Buelga, C., Francia-Aricha, E. M., & Escribano-Bailón, M. T. (1995) · Food Chemistry · doi:10.1016/0308-8146(95)90788-9 · Cited by 149
Resveratrol Concentration in Muscadine Berries, Juice, Pomace, Purees, Seeds, and Wines
Ector, B. J., Magee, J. B., Hegwood, C. P., et al. (1996) · American Journal of Enology and Viticulture · doi:10.5344/ajev.1996.47.1.57 · Cited by 127
Subchronic 3-month oral toxicity study of grape seed and grape skin extracts
Bentivegna, S. S., & Whitney, K. M. (2002) · Food and Chemical Toxicology · doi:10.1016/s0278-6915(02)00155-2 · Cited by 124
Reactive Oxygen Species and Intracellular Ca2, Common Signals for Apoptosis Induced by Gallic Acid
Sakaguchi, N., Inoue, M., & OGIHARA, Y. (1998) · Biochemical Pharmacology · doi:10.1016/s0006-2952(98)00041-0 · Cited by 109
Tebib, K., Rouanet, J. M., & Besançon, P. (1997) · Food Chemistry · doi:10.1016/s0308-8146(96)00253-1 · Cited by 78
Slominski, B. A., & Campbell, L. D. (1989) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf00089a020 · Cited by 68
Alkyl peroxyl radical-scavenging activity of catechins
Nakao, M., Takio, S., & Ono, K. (1998) · Phytochemistry · doi:10.1016/s0031-9422(98)00333-1 · Cited by 67
Chemopreventive effects of grape seed proanthocyanidin extract on Chang liver cells
Joshi, S. (2000) · Toxicology · doi:10.1016/s0300-483x(00)00280-8 · Cited by 64
Pearson, D. A., Schmitz, H. H., Lazarus, S. A., & Keen, C. L. (2001) · Methods in enzymology on CD-ROM/Methods in enzymology · doi:10.1016/s0076-6879(01)35257-6 · Cited by 56
Effects of dietary grape seed tannins on rat cecal fermentation and colonic bacterial enzymes
Tebib, K., Besançon, P., & Rouanet, J. (1996) · Nutrition Research · doi:10.1016/0271-5317(95)02064-0 · Cited by 49
Cited by
Biological Activities of Polyphenols from Grapes
Xia, E.-Q., Deng, G.-F., Guo, Y.-J., & Li, H.-B. (2010) · International Journal of Molecular Sciences · doi:10.3390/ijms11020622 · Cited by 1,063
Pinelo, M., Rubilar, M., Jerez, M., Sineiro, J., & Núñez, M. J. (2005) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf0488110 · Cited by 616
Green tea and grape seed extracts—Potential applications in food safety and quality
Perumalla, A. V. S., & Hettiarachchy, N. S. (2011) · Food Research International · doi:10.1016/j.foodres.2011.01.022 · Cited by 471
Study of solid–liquid extraction kinetics of total polyphenols from grape seeds
Bucić-Kojić, A., Planinić, M., Tomas, S., Bilić, M., & Velić, D. (2007) · Journal of Food Engineering · doi:10.1016/j.jfoodeng.2006.10.027 · Cited by 444
Molecular diversity in phenolic and polyphenolic precursors of tannin-inspired nanocoatings
Barrett, D. G., Sileika, T. S., & Messersmith, P. B. (2014) · Chem. Commun. · doi:10.1039/c4cc02961e · Cited by 286
Metadata
- Authors
- Yilmaz, Y., & Toledo, R. T.
- Venue
- Journal of Agricultural and Food Chemistry
- Publisher
- American Chemical Society (ACS)
- Published
- 2003-12-31
- Volume
- 52
- Issue
- 2
- Pages
- 255-260
- ISSN
- 0021-8561 (ISSN-L)
- 1520-5118
- OpenAlex
- W2091099722
- Cited by
- 734
- References
- 27
- FWCI
- 8.10
- Type
- journal article
- Language
- en
- Open access
- closed
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.