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A Novel Angiotensin I Converting Enzyme Inhibitory Peptide from Alaska Pollack (Theragra chalcogramma) Frame Protein Hydrolysate
Abstract
Alaska pollack frame protein, which is normally discarded as an industrial byproduct in the processing of fish in plants, was hydrolyzed with pepsin. This was fractionated into five major types of Alaska pollack frame protein hydrolysates (APH-I, 10-30 kDa; APH-II, 5-10 kDa; APH-III, 3-5 kDa; APH-IV, 1-3 kDa; and APH-V, below 1 kDa) using an ultrafiltration membrane bioreactor system. Angiotensin I converting enzyme (ACE) inhibitory activities of the fractionated hydrolysates were investigated, and the fraction that exhibited the highest ACE inhibitory activity was further purified using consecutive chromatographic methods on SP-Sephadex C-25 column, Sephadex G-25 column, and high-performance liquid chromatography (HPLC) on an octadecylsilane column. Finally, we purified a novel ACE inhibitory peptide with an IC50 value of 14.7 microM, and the sequence of the peptide was Phe-Gly-Ala-Ser-Thr-Arg-Gly-Ala. In addition, the ACE inhibition pattern of the peptide was found to be noncompetitive.
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Cited by
Fish Waste: From Problem to Valuable Resource
Coppola, D., Lauritano, C., Palma Esposito, F., Riccio, G., Rizzo, C., & de Pascale, D. (2021) · Marine Drugs · doi:10.3390/md19020116 · Cited by 592
Ngo, D.-H., Vo, T.-S., Ngo, D.-N., Wijesekara, I., & Kim, S.-K. (2012) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2012.06.001 · Cited by 301
Self-citationVo, T.-S., Ryu, B., & Kim, S.-K. (2013) · Journal of Functional Foods · doi:10.1016/j.jff.2013.05.001 · Cited by 209
Self-citationPan, S., Wang, S., Jing, L., & Yao, D. (2016) · Food Chemistry · doi:10.1016/j.foodchem.2016.05.087 · Cited by 110
Metadata
- Authors
- Je, J.-Y., Park, P.-J., Kwon, J. Y., & Kim, S.-K.
- Venue
- Journal of Agricultural and Food Chemistry
- Publisher
- American Chemical Society (ACS)
- Published
- 2004-11-24
- Volume
- 52
- Issue
- 26
- Pages
- 7842-7845
- ISSN
- 0021-8561 (ISSN-L)
- 1520-5118
- OpenAlex
- W2025521338
- Cited by
- 199
- References
- 0
- FWCI
- 1.42
- Type
- journal article
- Language
- en
- Open access
- closed
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- CoChat. (2026). Citation check: A Novel Angiotensin I Converting Enzyme Inhibitory Peptide from Alaska Pollack (Theragra chalcogramma) Frame Protein Hydrolysate. https://app.cochat.ai/papers/10.1021/jf0494027
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- Je, J.-Y., Park, P.-J., Kwon, J. Y., & Kim, S.-K. (2004). A Novel Angiotensin I Converting Enzyme Inhibitory Peptide from Alaska Pollack (Theragra chalcogramma) Frame Protein Hydrolysate. Journal of Agricultural and Food Chemistry. https://doi.org/10.1021/jf0494027
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