The DOI matches its Crossref record; 12 of the 12 references it cites were found in a registry or an index.
Triterpenoids Isolated from Apple Peels Have Potent Antiproliferative Activity and May Be Partially Responsible for Apple's Anticancer Activity
Abstract
Bioactivity-guided fractionation of apple peels was used to determine the chemical identity of bioactive constituents. Thirteen triterpenoids were isolated, and their chemical structures were identified. Antiproliferative activities of the triterpenoids against human HepG2 liver cancer cells, MCF-7 breast cancer cells, and Caco-2 colon cancer cells were evaluated. Most of the triterpenoids showed high potential anticancer activities against the three human cancer cell lines. Among the compounds isolated, 2alpha-hydroxyursolic acid, 2alpha-hydroxy-3beta-{[(2E)-3-phenyl-1-oxo-2-propenyl]oxy}olean-12-en-28-oic acid, and 3beta-trans-p-coumaroyloxy-2alpha-hydroxyolean-12-en-28-oic acid showed higher antiproliferative activity toward HepG2 cancer cells. Ursolic acid, 2alpha-hydroxyursolic acid, and 3beta-trans-p-coumaroyloxy-2alpha-hydroxyolean-12-en-28-oic acid exhibited higher antiproliferative activity against MCF-7 cancer cells. All triterpenoids tested showed antiproliferative activity against Caco-2 cancer cells, especially 2alpha-hydroxyursolic acid, maslinic acid, 2alpha-hydroxy-3beta-{[(2E)-3-phenyl-1-oxo-2-propenyl]oxy}olean-12-en-28-oic acid, and 3beta-trans-p-coumaroyloxy-2alpha-hydroxyolean-12-en-28-oic acid, which displayed much higher antiproliferative activities. These results showed the triterpenoids isolated from apple peels have potent antiproliferative activity and may be partially responsible for the anticancer activities of whole apples.
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Cites
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Self-citationAntioxidant and Antiproliferative Activities of Common Fruits
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Self-citationDiet and Health: What Should We Eat?
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Cited by
Health-promoting components of fruits and vegetables in the diet.
Liu, R. H. (2013) · Advances in Nutrition · doi:10.3945/an.112.003517 · Cited by 1,310
Self-citationDietary Bioactive Compounds and Their Health Implications
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Self-citationA Comprehensive Review of Apples and Apple Components and Their Relationship to Human Health
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Targeting inflammatory pathways by triterpenoids for prevention and treatment of cancer.
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Maslinic Acid, a Natural Phytoalexin-Type Triterpene from Olives — A Promising Nutraceutical?
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Metadata
- Authors
- He, X., & Liu, R. H.
- Venue
- Journal of Agricultural and Food Chemistry
- Publisher
- American Chemical Society (ACS)
- Published
- 2007-05-01
- Volume
- 55
- Issue
- 11
- Pages
- 4366-4370
- ISSN
- 0021-8561 (ISSN-L)
- 1520-5118
- OpenAlex
- W2052126027
- Cited by
- 301
- References
- 12
- FWCI
- 6.47
- Type
- journal article
- Language
- en
- Open access
- closed
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- He, X., & Liu, R. H. (2007). Triterpenoids Isolated from Apple Peels Have Potent Antiproliferative Activity and May Be Partially Responsible for Apple's Anticancer Activity. Journal of Agricultural and Food Chemistry. https://doi.org/10.1021/jf063563o
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