Maslinic Acid, a Natural Phytoalexin-Type Triterpene from Olives — A Promising Nutraceutical?

Lozano-Mena, Glòria; Sánchez-González, Marta; Juan, M.; Planas, Joana

doi:10.3390/molecules190811538

Cited by 151Natural product bioactivities and synthesisPhytochemical Studies and BioactivitiesPhytochemical compounds biological activities

Maslinic Acid, a Natural Phytoalexin-Type Triterpene from Olives — A Promising Nutraceutical?

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Lozano-Mena, Glòria, Sánchez-González, Marta, Juan, M., Planas, Joana·2014·Molecules

DOI 10.3390/molecules190811538PMC PMC6271970

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Abstract

Maslinic acid is a pentacyclic triterpene found in a variety of natural sources, ranging from herbal remedies used in traditional Asian medicine to edible vegetables and fruits present in the Mediterranean diet. In recent years, several studies have proved that maslinic acid exerts a wide range of biological activities, i.e. antitumor, antidiabetic, antioxidant, cardioprotective, neuroprotective, antiparasitic and growth-stimulating. Experimental models used for the assessment of maslinic acid effects include established cell lines, which have been often used to elucidate the underlying mechanisms of action, and also animal models of different disorders, which have confirmed the effects of the triterpene in vivo. Overall, and supported by the lack of adverse effects in mice, the results provide evidence of the potential of maslinic acid as a nutraceutical, not only for health promotion, but also as a therapeutic adjuvant in the treatment of several disorders.

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Trials in several animal models have reported reductions in serum TC, TG, LDL-C or VLDL-C and/or increased HDL-C concentrations following oral administration of different doses of MA, OA or high but not low doses of ursolic acid.
“Trials in several animal models have also reported reductions in serum TC, TG, LDL-C or VLDL-C and/or increased HDL-C concentrations following oral administration of different doses (15–100 mg/kg/d) of MA [reviewed in 26], OA (5–25 mg/kg/d) [25–29] or high (200 mg/kg/d) but not low (50 mg/kg/d) doses of ursolic acid (UA) [30].”
From Olive pomace oil can improve blood lipid profile: a randomized, blind, crossover, controlled clinical trial in healthy and at-risk volunteers (2022) · cites this paper as [26]

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Maslinic acid promotes synaptogenesis and axon growth via Akt/GSK-3β activation in cerebral ischemia model
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Maslinic acid suppresses macrophage foam cells formation: Regulation of monocyte recruitment and macrophage lipids homeostasis
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Maslinic acid exerts anticancer effects by targeting cancer hallmarks
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Maslinic acid solid lipid nanoparticles as hydrophobic anticancer drug carriers: Formulation, in vitro activity and in vivo biodistribution
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Bioactive substances in black ripe olives produced in Spain and the USA
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Unveiling the molecular mechanisms and clinical implications of maslinic acid in diabetes mellitus: Insights from network pharmacology
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The Role of Triterpenoids in Gastric Ulcer: Mechanisms and Therapeutic Potentials
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Maslinic acid activates mTORC1 and human TGR5 and induces skeletal muscle hypertrophy
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Solid lipid nanoparticles to improve bioaccessibility and permeability of orally administered maslinic acid
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Evaluation of pentacyclic triterpenes found inPerilla frutescensfor inhibition of skin tumor promotion by 12-O-tetradecanoylphorbol-13-acetate
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IL-6/STAT3 signaling activation exacerbates high fructose-induced podocyte hypertrophy by ketohexokinase-A-mediated tristetraprolin down-regulation
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Jasminum sambac Cell Extract as Antioxidant Booster against Skin Aging
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Biotransformation of oleanolic and maslinic methyl esters by Rhizomucor miehei CECT 2749
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Authors: Lozano-Mena, G., Sánchez-González, M., Juan, M., & Planas, J.
Affiliations: Departament de Fisiologia and Institut de Recerca en Nutrició i Seguretat Alimentària (INSA-UB), Universitat de Barcelona (UB), Av. Joan XXIII s/n, 08028 Barcelona, Spain
Universitat de Barcelona (ES)
ORCID: Juan, M.
Planas, Joana
Venue: Molecules
Publisher: MDPI AG
Published: 2014-08-04
Volume: 19
Issue: 8
Pages: 11538-11559
ISSN: 1420-3049 (ISSN-L)
DOI: 10.3390/molecules190811538
PMC: PMC6271970
OpenAlex: W2104408104
Cited by: 151
References: 95
Citations by year: 2026: 8 · 2025: 13 · 2024: 11 · 2023: 10 · 2022: 20 · 2021: 21 · 2020: 18 · 2019: 8 · 2018: 11 · 2017: 10 · 2016: 11 · 2015: 9 · 2014: 1
FWCI: 0.97
Type: journal article
Language: en
Open access: gold
doi.org
Licence: cc-by
creativecommons.org/licenses/by/3.0/ (vor)
Locations: Molecules (publishedVersion, cc-by)
Europe PMC (PubMed Central) (publishedVersion, cc-by)
PubMed Central (publishedVersion, cc-by)
PubMed (publishedVersion)
Dipòsit Digital de la Universitat de Barcelona (Universitat de Barcelona) (submittedVersion, cc-by)
DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
Funders: Ministerio de Ciencia e Innovación (AGL2009-12866, AGL2013-41188)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Natural product bioactivities and synthesis
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Phytochemical Studies and Bioactivities
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Phytochemical compounds biological activities
Keywords: maslinic acid, phytoalexins, pentacyclic triterpenes, olive, nutraceuticals, anticancer activity, antidiabetic activity, antioxidant activity, cardioprotection, neuroprotection, antiparasitic activity, growth promotion, therapeutic adjuvant
MeSH terms: Animals, Biological Products, Humans, Oleanolic Acid, Triterpenes, Molecular Structure, Dietary Supplements, Olea, Phytochemicals

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Maslinic Acid, a Natural Phytoalexin-Type Triterpene from Olives — A Promising Nutraceutical?

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