Purification, Identification, and Characterization of Methylcobalamin from Spirulina platensis

Algae acquire vitamin B12 through a symbiotic relationship with bacteria

Croft, M. T., Lawrence, A. D., Raux-Deery, E., Warren, M. J., & Smith, A. G. (2005) · Nature · doi:10.1038/nature04056 · Cited by 1,536 · see citing works

Present knowledge in nutrition

Brown, M. L. (1990) · JAMA · doi:10.1001/jama.1954.03690350086043 · Cited by 777 · see citing works

Vitamin B 12

Stadtman, T. C. (1971) · Science · doi:10.1126/science.171.3974.859 · Cited by 543 · see citing works

Pseudovitamin B 12 Is the Predominant Cobamide of an Algal Health Food, Spirulina Tablets

Watanabe, F., Katsura, H., Takenaka, S., Fujita, T., Abe, K., Tamura, Y., Nakatsuka, T., & Nakano, Y. (1999) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf990541b · Cited by 154 · see citing works

Vitamin B-12 from algae appears not to be bioavailable

Dagnelie, P. C., van Staveren, W., & van den Berg, H. (1991) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/53.3.695 · Cited by 109 · see citing works

Production and utilization of the blue-green alga Spirulina in India

Becker, E. W., & Venkataraman, L. V. (1984) · Biomass · doi:10.1016/0144-4565(84)90060-x · Cited by 104 · see citing works

Nutrient intake and vitamin status of healthy French vegetarians and nonvegetarians

Millet, P., Guilland, J.-C., Fuchs, F., & Klepping, J. (1989) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/50.4.718 · Cited by 85 · see citing works

Feeding dried purple laver (nori) to vitamin B12-deficient rats significantly improves vitamin B12 status

Takenaka, S., Sugiyama, S., Ebara, S., Miyamoto, E., Abe, K., Tamura, Y., Watanabe, F., Tsuyama, S., & Nakano, Y. (2001) · British Journal Of Nutrition · doi:10.1079/bjn2001352 · Cited by 63 · see citing works

Vitamin B-12 Status of Long-Term Adherents of a Strict Uncooked Vegan Diet (“Living Food Diet”) Is Compromised

Elorinne, A., Törrönen, R., Hänninen, O., & Mykkänen, H. M. (1995) · Journal of Nutrition · doi:10.1093/jn/125.10.2511 · Cited by 61 · see citing works

Blockade of vitamin B12-binding sites in gastric juice serum and saliva by analogues and derivatives of vitamin B12 and by antibody to intrinsic factor

Gottlieb, C. W., Retief, F., & Herbert, V. D. (1967) · Biochimica et Biophysica Acta (BBA) - General Subjects · doi:10.1016/0304-4165(67)90185-7 · Cited by 55 · see citing works

Comparison of a Microbiological Assay and a Fully Automated Chemiluminescent System for the Determination of Vitamin B12 in Food

Watanabe, F., Takenaka, S., Abe, K., Tamura, Y., & Nakano, Y. (1998) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf970807j · Cited by 50 · see citing works

Spirulina and Vitamin B12

Herbert, V., & Drivas, G. J. (1982) · JAMA · doi:10.1001/jama.1982.03330230018017 · Cited by 48 · see citing works

Characterization of a Vitamin B12Compound in the Edible Purple Laver,Porphyra yezoensis

Watanabe, F., Takenaka, S., Katsura, H., Miyamoto, E., Abe, K., Tamura, Y., Nakatsuka, T., & Nakano, Y. (2000) · Bioscience Biotechnology and Biochemistry · doi:10.1271/bbb.64.2712 · Cited by 47 · see citing works

The assay of vitamin B12. Part VI. Microbiological estimation with a mutant of Escherichia coli by the plate method

Harrison, E., Lees, K. A., & Wood, F. L. (1951) · The Analyst · doi:10.1039/an9517600696 · Cited by 47 · see citing works

Enhancement of chemiluminescence for vitamin B12 analysis

Kumar, S. S., Chouhan, R. S., & Thakur, M. S. (2009) · Analytical Biochemistry · doi:10.1016/j.ab.2009.02.029 · Cited by 45 · see citing works

VITAMIN B12 AND SEAWEED

van den Berg, H., Dagnelie, P. C., & van Staveren, W. A. (1988) · The Lancet · doi:10.1016/s0140-6736(88)91093-8 · Cited by 43 · see citing works

Improved techniques for the extraction and chromatography of cobalamins

Fenton, W. A., & Rosenberg, L. E. (1978) · Analytical Biochemistry · doi:10.1016/0003-2697(78)90014-3 · Cited by 40 · see citing works

Purification and Characterization of a Corrinoid Compound from Chlorella Tablets as an Algal Health Food

Kittaka‐Katsura, H., Fujita, T., Watanabe, F., & Nakano, Y. (2002) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf020345w · Cited by 39 · see citing works

VITAMINS IN ALGAE

Kanazawa, A. (1963) · NIPPON SUISAN GAKKAISHI · doi:10.2331/suisan.29.713 · Cited by 32 · see citing works

Content and Characteristics of Vitamin B12 in Some Seaweeds.

Yamada, S., SHIBATA, Y., TAKAYAMA, M., NARITA, Y., Sugawara, K., & Fukuda, M. (1996) · Journal of Nutritional Science and Vitaminology · doi:10.3177/jnsv.42.497 · Cited by 30 · see citing works

Determination of Pantothenic Acid, Biotin, and Vitamin B12 in Nutritional Products

Hudson, T. S., Subramanian, S., & Allen, R. J. (1984) · Journal of AOAC INTERNATIONAL · doi:10.1093/jaoac/67.5.994 · Cited by 30 · see citing works

Form of Vitamin B 12 and Its Role in a Methanol-Utilizing Bacterium Protaminobacter ruber

Sato, K., Ueda, S., & Shimizu, S. (1977) · Applied and Environmental Microbiology · doi:10.1128/aem.33.3.515-521.1977 · Cited by 27 · see citing works

Inactive Corrinoid-Compound Significantly Decreases in Spirulina platensis Grown in a Cobalt-Deficient Medium

Watanabe, F., Miyamoto, E., & Nakano, Y. (2001) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf010733i · Cited by 16 · see citing works

TLC SEPARATION AND ANALYSIS OF VITAMIN B12AND RELATED COMPOUNDS IN FOOD

Watanabe, F., & Miyamoto, E. (2002) · Journal of Liquid Chromatography & Related Technologies · doi:10.1081/jlc-120005704 · Cited by 10 · see citing works

6 The Occurrence and Distribution or Corrinoids

Schneider, Z. (1987) · De Gruyter eBooks · doi:10.1515/9783110844795.157 · Cited by 7 · see citing works

Nutritional and medical applications of spirulina microalgae

Hoseini, S. M., Khosravi-Darani, K., & Mozafari, M. R. (2013) · Mini-Reviews in Medicinal Chemistry · doi:10.2174/1389557511313080009 · Cited by 326 · see citing works

Antioxidant, Immunomodulating, and Microbial‐Modulating Activities of the Sustainable and Ecofriendly <i>Spirulina</i>

Finamore, A., Palmery, M., Bensehaila, S., & Peluso, I. (2017) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2017/3247528 · Cited by 256 · see citing works

Potential of Microalgal Bioproducts: General Perspectives and Main Challenges

de Souza, M. P., Hoeltz, M., Gressler, P. D., Benitez, L. B., & Schneider, R. D. C. D. S. (2018) · Waste and Biomass Valorization · doi:10.1007/s12649-018-0253-6 · Cited by 93 · see citing works

Microalgae and Clean Technologies: A Review

de Souza, M. P., Hoeltz, M., Benitez, L. B., Machado, Ê. L., & Schneider, R. D. C. D. S. (2019) · CLEAN - Soil Air Water · doi:10.1002/clen.201800380 · Cited by 44 · see citing works

Biologically active or just “pseudo”-vitamin B12 as predominant form in algae-based nutritional supplements?

van den Oever, S. P., & Mayer, H. K. (2022) · Journal of Food Composition and Analysis · doi:10.1016/j.jfca.2022.104464 · Cited by 42 · see citing works

Methylcobalamin – A form of vitamin B12 identified and characterised in Chlorella vulgaris

Kumudha, A., Selvakumar, S., Dilshad, P., Vaidyanathan, G., Thakur, M. S., & Sarada, R. (2014) · Food Chemistry · doi:10.1016/j.foodchem.2014.08.035 · Cited by 44 · see citing works

Competitive immunoassay for analysis of vitamin B12

Kumar, L. S. S., & Thakur, M. S. (2011) · Analytical Biochemistry · doi:10.1016/j.ab.2011.07.011 · Cited by 38 · see citing works

Protein, phycocyanin, and polysaccharide production by Arthrospira platensis grown with LED light in annular photobioreactors

Zanolla, V., Biondi, N., Niccolai, A., Abiusi, F., Adessi, A., Rodolfi, L., & Tredici, M. R. (2022) · Journal of Applied Phycology · doi:10.1007/s10811-022-02707-0 · Cited by 37 · see citing works

Spirulina in the 21st century: Five reasons for success in Europe

Vieira, V. V., Benemann, J. R., Vonshak, A., Belay, A., Ras, M., Unamunzaga, C., Cadoret, J., & Rizzo, A. (2025) · Journal of Applied Phycology · doi:10.1007/s10811-025-03536-7 · Cited by 28 · see citing works

In Vivo Real-Time Simultaneous Examination of Drug Kinetics at Two Separate Locations Using Boron-Doped Diamond Microelectrodes

Hanawa, A., Ogata, G., Sawamura, S., Asai, K., Kanzaki, S., Hibino, H., & Einaga, Y. (2020) · Analytical Chemistry · doi:10.1021/acs.analchem.0c01707 · Cited by 28 · see citing works

A Review of the Health-Promoting Properties of Spirulina with a Focus on athletes’ Performance and Recovery

Chaouachi, M., Vincent, S., & Groussard, C. (2023) · Journal of Dietary Supplements · doi:10.1080/19390211.2023.2208663 · Cited by 30 · see citing works

Effect of Different Extraction Methods on Vitamin B12 from Blue Green Algae, Spirulina Platensis

Kumudha, A. (2015) · Pharmaceutica Analytica Acta · doi:10.4172/2153-2435.1000337 · Cited by 26 · see citing works

Dipstick based immunochemiluminescence biosensor for the analysis of vitamin B12 in energy drinks: A novel approach

Selvakumar, L. S., & Thakur, M. S. (2012) · Analytica Chimica Acta · doi:10.1016/j.aca.2012.02.006 · Cited by 25 · see citing works

Photolysis of methylcobalamin in aqueous solution: A kinetic study

Vaid, F. H. M., Zahid, S., Faiyaz, A., Qadeer, K., Gul, W., Anwar, Z., & Ahmad, I. (2018) · Journal of Photochemistry and Photobiology A Chemistry · doi:10.1016/j.jphotochem.2018.05.011 · Cited by 22 · see citing works

Improvement of vitamin B 12 status with Spirulina supplementation in Wistar rats validated through functional and circulatory markers

Krishnamurthi, D., Rashmi, V., Chauhan, V. S., Shylaja, M. D., & Ravi, S. (2019) · Journal of Food Biochemistry · doi:10.1111/jfbc.13038 · Cited by 21 · see citing works

Characterization of vitamin B12 in Dunaliella salina

Kumudha, A., & Sarada, R. (2015) · Journal of Food Science and Technology · doi:10.1007/s13197-015-2005-y · Cited by 20 · see citing works

Assessment of various colored lights on the growth pattern and secondary metabolites synthesis in Spirulina platensis

Sohani, E., Shariati, F. P., & Shariati, S. R. P. (2022) · Preparative Biochemistry & Biotechnology · doi:10.1080/10826068.2022.2098320 · Cited by 19 · see citing works

Algae-Based Bioremediation

Vidyashankar, S., & Ravishankar, G. A. (2015) · Elsevier eBooks · doi:10.1016/b978-0-12-802830-8.00018-6 · Cited by 18 · see citing works

Use of detoxified jatropha kernel meal and protein isolate in diets of farm animals.

Makkar, H. P. S., Kumar, V., & Becker, K. (2012) · Cited by 15 · see citing works

Comparison of copper and zinc in vitro bioaccessibility from cyanobacteria rich in proteins and a synthetic supplement containing gluconate complexes: LC–MS mapping of bioaccessible copper complexes

Wojcieszek, J., Witkoś, K., Ruzik, L., & Pawlak, K. (2015) · Analytical and Bioanalytical Chemistry · doi:10.1007/s00216-015-9162-8 · Cited by 14 · see citing works

Gastro-protective potentials of Spirulina: role of vitamin B12

Kumudha, A., Dharmesh, S. M., & Ravi, S. (2019) · Journal of Food Science and Technology · doi:10.1007/s13197-019-04107-8 · Cited by 12 · see citing works

The microalgae’s ability to accumulate selected trace elements studied by ICP-MS/MS and chemometric methods

Zdziebłowska, S., Czarnecki, M., Ciosek, P., & Ruzik, L. (2023) · Journal of Trace Elements in Medicine and Biology · doi:10.1016/j.jtemb.2023.127351 · Cited by 7 · see citing works

Algae as a Functional Food: A Case Study on Spirulina

Stunda-Zujeva, A., & Berele, M. (2023) · Springer eBooks · doi:10.1007/978-3-031-42026-9_17 · Cited by 8 · see citing works

Effect of Resistance Training and Spirulina platensis on Expression of IL-6, Gp130 Cytokines, JAK-STAT Signaling in Male Rats Skeletal Muscle

Zar, A., Ahmadi, F., Karimi, F., Ahmadi, M., & Ramsbottom, R. (2022) · Molecular & cellular biomechanics · doi:10.32604/mcb.2022.018345 · Cited by 4 · see citing works

Phyto-functionalized niosomal gel for acne therapy: Dual delivery of clindamycin and botanical actives via a sustained topical platform - in vitro, ex vivo, in silico and in vivo evaluation

Mehraliyeva, S. J., Rəcəb, N. İ., Rafik, İ. J., Bayram, S. J., & Öztürk, A. A. (2026) · Journal of Drug Delivery Science and Technology · doi:10.1016/j.jddst.2026.108313 · Cited by 2 · see citing works

Ascorbic acid assisted photodegradation of methylcobalamin using corrective irrelevant absorption spectrophotometric assay: A kinetic study

Zahid, S., Anwar, Z., Qadeer, K., Ejaz, M. A., Wajidi, M., Yasin, H., Fatima, K., Razzak, M., Noreen, A., Vaid, F. H. M., et al. (2024) · Spectrochimica Acta Part A Molecular and Biomolecular Spectroscopy · doi:10.1016/j.saa.2024.124902 · Cited by 2 · see citing works

Interet D’une Supplementation En Spiruline Chez Les Enfants Drepanocytaires Homozygotes A L’hopital National De Niamey. (Essai Clinique Randomise En Double Aveugle A Propos De 53 Cas)

Malam-Abdou, B., Brah, S., Andia, A., Sani, M., Elhadji-Chefou, M., Ibrahim, F., Diongole, H., Adamou, H., Daouda, I., Alhousseini Maïga, D., et al. (2017) · European Scientific Journal ESJ · doi:10.19044/esj.2017.v13n21p208 · Cited by 2 · see citing works

Vegetarian Diets in Health Promotion and Disease Prevention

Fernández, C., Adams, K. M., & Kohlmeier, M. (2013) · CRC Press eBooks · doi:10.1201/b15294-30 · Cited by 2 · see citing works

NEGYVŪNINĖS KILMĖS MAISTO PAPILDŲ SUKELIAMA VITAMINO B12 PSEUDOVITAMINOZĖ

Šukevič, B. (2024) · Health Sciences · doi:10.35988/sm-hs.2024.181

Valorisation des effets de la Spiruline sur la nutrition, la composition corporelle, la performance et la récupération chez des rugbymen de haut niveau

Chaouachi, M. (2023) · doi:10.70675/540ad4a4z49e6z4b04z9474zaeb904b70e60

Purification, Identification, and Characterization of \nMethylcobalamin from Spirulina platensis.

Kumudha, A., Selvakumar, S., Thakur, M. S., Ravishankar, G. A., & Sarada, R. (2010) · CFTRI Institutional Repository

Methylcobalamin – A form of vitamin B12 identified and characterised \nin Chlorella vulgaris.

Kumudha, A., Selvakumar, S., Dilshad, P., Gopal, V., Thakur, M. S., & Sarada, R. (2015) · CFTRI Institutional Repository

Methylcobalamin – A form of vitamin B12 identified and characterised in Chlorella vulgaris

Kumudha, A., Selvakumar, S., Dilshad, P., Vaidyanathan, G., Thakur, M. S., & Sarada, R. (2014) · Food Chemistry · doi:10.1016/j.foodchem.2014.08.035 · Cited by 44 · see citing works

Effect of Different Extraction Methods on Vitamin B12 from Blue Green Algae, Spirulina Platensis

Kumudha, A. (2015) · Pharmaceutica Analytica Acta · doi:10.4172/2153-2435.1000337 · Cited by 26 · see citing works

Effect of Different Extraction Methods on Vitamin B12 from Blue Green \nAlgae, Spirulina Platensis

Kumudha, A., & Sarada, R. (2015) · CFTRI Institutional Repository