The DOI matches its Crossref record; 43 of the 43 references it cites were found in a registry or an index.
Enhanced Dispersibility and Bioactivity of Curcumin by Encapsulation in Casein Nanocapsules
Abstract
In this work, a novel encapsulation method was studied by spray-drying a warm aqueous ethanol solution with codissolved sodium caseinate (NaCas) and lipophilic food components, using curcumin as a model compound. The encapsulation caused the loss of crystallinity of curcumin. After hydration of spray-dried powder and centrifugation, 137 μg/mL curcumin was dispersed in the transparent dispersion, which was 4 decades higher than its water solubility. Dynamic light scattering and atomic force microscopy results showed that curcumin-loaded casein nanoparticles were bigger than those of NaCas processed at encapsulation conditions but were smaller than those of the native NaCas. The increased nanoparticle dimension, together with fluorescence and FTIR spectroscopy results, suggested that curcumin was entrapped in the nanoparticle core through hydrophobic interactions. The curcumin encapsulated in casein nanoparticles had higher biological activity, as assessed by antioxidant and cell proliferation assays, than pristine curcumin, likely due to the improved dispersibility. This simple approach may be applied to encapsulate various lipophilic bioactive compounds.
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Cites
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Cited by
Antibacterial Action of Curcumin against Staphylococcus aureus: A Brief Review
Teow, S.-Y., Liew, K., Ali, S. A., Khoo, A. S.-B., & Peh, S.-C. (2016) · Journal of Tropical Medicine · doi:10.1155/2016/2853045 · Cited by 328
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Hydrocolloid-food component interactions
Gao, Z., Fang, Y., Cao, Y., Liao, H., Nishinari, K., & Phillips, G. O. (2017) · Food Hydrocolloids · doi:10.1016/j.foodhyd.2016.08.042 · Cited by 117
Metadata
- Authors
- Pan, K., Zhong, Q., & Baek, S. J.
- Venue
- Journal of Agricultural and Food Chemistry
- Publisher
- American Chemical Society (ACS)
- Published
- 2013-06-14
- Volume
- 61
- Issue
- 25
- Pages
- 6036-6043
- ISSN
- 0021-8561 (ISSN-L)
- 1520-5118
- OpenAlex
- W2025086371
- Cited by
- 441
- References
- 43
- FWCI
- 41.09
- Type
- journal article
- Language
- en
- Open access
- closed
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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