The DOI matches its Crossref record; 4 of the 4 references it cites were found in a registry or an index.
Structure−Activity Relationships of Flavonoids in the Cellular Antioxidant Activity Assay
Abstract
Chemical antioxidant activity assays are used extensively to evaluate the potential bioactivity of plant foods and their phytochemical constituents, but they do not mimic the complexity of biological systems. The cellular antioxidant activity (CAA) activity assay was developed to be a more biologically relevant model to measure antioxidant activity. Structure-activity relationships of flavonoids have been determined in many chemistry antioxidant activity assays, and they vary with the protocols. The objective of this study was to determine structure-activity relationships of selected flavonoids in the CAA assay. The structures that conferred flavonoids with the most antioxidant activity in the CAA assay were a 3',4'- o-dihydroxyl group in the B-ring, a 2,3-double bond combined with a 4-keto group in the C-ring, and a 3-hydroxyl group. Isoflavones had no cellular antioxidant activity. Flavanols with a galloyl moiety had higher antioxidant activity than those without, and a B-ring 3',4',5'-trihydroxyl group further improved their efficacy. ORAC values for flavonoids were not related to their CAA values. Knowledge of structure-activity relationships in the CAA assay may be helpful in assessing potential in vivo antioxidant activity of flavonoids.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Structure-antioxidant activity relationships of flavonoids and phenolic acids
Rice-Evans, C. A., Miller, N. J., & Paganga, G. (1996) · Free Radical Biology and Medicine · doi:10.1016/0891-5849(95)02227-9 · Cited by 9,085
Vegetables, Fruit, and Cancer Prevention
STEINMETZ, K. A., & POTTER, J. D. (1996) · Journal of the American Dietetic Association · doi:10.1016/s0002-8223(96)00273-8 · Cited by 2,118
Flavonoids: antioxidants or signalling molecules?
Williams, R. J., Spencer, J. P. E., & Rice-Evans, C. (2004) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2004.01.001 · Cited by 2,016
Flavonols, Flavones, Flavanones, and Human Health: Epidemiological Evidence
Graf, B. A., Milbury, P. E., & Blumberg, J. B. (2005) · Journal of Medicinal Food · doi:10.1089/jmf.2005.8.281 · Cited by 556
Cited by
Natural and synthetic antioxidants: An updated overview
Augustyniak, A., Bartosz, G., Čipak, A., Duburs, G., Horáková, L., Łuczaj, W., Majekova, M., Odysseos, A. D., Rackova, L., Skrzydlewska, E., et al. (2010) · Free Radical Research · doi:10.3109/10715762.2010.508495 · Cited by 319
Antioxidant properties of flavonoids
Banjarnahor, S. D. S., & Artanti, N. (2015) · Medical Journal of Indonesia · doi:10.13181/mji.v23i4.1015 · Cited by 310
Nutrition, Well-Being and Health
(2012) · doi:10.5772/1864 · Cited by 178
Evaluation of Polyphenolics Content and Antioxidant Activity in Edible Wild Fruits
Shan, S., Huang, X., Shah, M. H., & Abbasi, A. M. (2019) · BioMed Research International · doi:10.1155/2019/1381989 · Cited by 84
“are mainly accredited to the additive and synergetic effects of phytochemicals [33], such as vitamins, minerals, and polyphenols that provide protection to cellular system against oxidative impairment and consequently reduce the oxidative stress [34].”
BackgroundPacheco-Ordaz, R., Antunes-Ricardo, M., Gutiérrez-Uribe, J., & González-Aguilar, G. (2018) · International Journal of Molecular Sciences · doi:10.3390/ijms19020514 · Cited by 67
Metadata
- Authors
- Wolfe, K. L., & Liu, R. H.
- Venue
- Journal of Agricultural and Food Chemistry
- Publisher
- American Chemical Society (ACS)
- Published
- 2008-08-15
- Volume
- 56
- Issue
- 18
- Pages
- 8404-8411
- ISSN
- 0021-8561 (ISSN-L)
- 1520-5118
- OpenAlex
- W1972510752
- Cited by
- 392
- References
- 4
- FWCI
- 9.83
- Type
- journal article
- Language
- en
- Open access
- closed
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
