The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Effect of Prolyl-hydroxyproline (Pro-Hyp), a Food-Derived Collagen Peptide in Human Blood, on Growth of Fibroblasts from Mouse Skin
Abstract
We examined the effect of prolyl-hydroxyproline (Pro-Hyp), which occurs in human peripheral blood after ingestion of collagen peptide, on the migration and growth of mouse skin fibroblasts. Mouse skin discs were cultured on a 24-well plastic plate in a fetal bovine serum (FBS)-free medium. Addition of Pro-Hyp (200 nmol/mL) significantly increased the number of fibroblasts migrating from the skin to the plate after incubation for 72 h. This effect of Pro-Hyp was abolished by the addition of mitomycin C. The fibroblasts that had migrated from the mouse skin were collected and cultured on collagen gel. The growth of fibroblasts on the collagen gel was suppressed even in the presence of FBS, while rapid fibroblast growth was observed on the plastic plate. Addition of Pro-Hyp (0-1000 nmol/mL) to the medium containing 10% FBS enhanced the growth of fibroblasts on the collagen gel in a dose-dependent manner. These results suggest that Pro-Hyp might stimulate the growth of fibroblasts in the skin and consequently increase the number of fibroblasts migrating from the skin.
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Cites
Inflammatory cells during wound repair: the good, the bad and the ugly
Martin, P., & Leibovich, S. J. (2005) · Trends in Cell Biology · doi:10.1016/j.tcb.2005.09.002 · Cited by 1,340
Cited by
Cicero, A. F. G., Fogacci, F., & Colletti, A. (2017) · British Journal of Pharmacology · doi:10.1111/bph.13608 · Cited by 317
Asserin, J., Lati, E., Shioya, T., & Prawitt, J. (2015) · Journal of Cosmetic Dermatology · doi:10.1111/jocd.12174 · Cited by 260
Bioactive peptides in cereals and legumes: agronomical, biochemical and clinical aspects.
Malaguti, M., Dinelli, G., Leoncini, E., Bregola, V., Bosi, S., Cicero, A., & Hrelia, S. (2014) · International Journal of Molecular Sciences · doi:10.3390/ijms151121120 · Cited by 180
Collagen peptides and the related synthetic peptides: A review on improving skin health
Zhao, X., Zhang, X., & Liu, D. (2021) · Journal of Functional Foods · doi:10.1016/j.jff.2021.104680 · Cited by 133
Holwerda, A. M., & van Loon, L. J. C. (2022) · Nutrition Reviews · doi:10.1093/nutrit/nuab083 · Cited by 117
Metadata
- Authors
- Shigemura, Y., Iwai, K., Morimatsu, F., Iwamoto, T., Mori, T., Oda, C., Taira, T., Park, E. Y., Nakamura, Y., & Sato, K.
- Venue
- Journal of Agricultural and Food Chemistry
- Publisher
- American Chemical Society (ACS)
- Published
- 2009-01-07
- Volume
- 57
- Issue
- 2
- Pages
- 444-449
- ISSN
- 0021-8561 (ISSN-L)
- 1520-5118
- OpenAlex
- W2064696741
- Cited by
- 230
- References
- 1
- FWCI
- 4.10
- Type
- journal article
- Language
- en
- Open access
- closed
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